The internal dimension of tasks

2014 ◽  
pp. 27-52 ◽  
Author(s):  
Rosa M. Manchón
Keyword(s):  
Internal Dimension

Protective Effect of Swertiamarin on Myocardial Injury Through Activation of Nrf2/HO-1 Pathway in Heart Failure Model of Rats

2020 ◽  
Vol 18 (3) ◽  
pp. 260-265
Author(s):  
Xu Lin ◽  
Zheng Xiaojun ◽  
Lv Heng ◽  
Mo Yipeng ◽  
Tong Hong
Keyword(s):  
Oxidative Stress ◽  
Heart Failure ◽  
Ejection Fraction ◽  
Protective Effect ◽  
Infarct Size ◽  
Rat Model ◽  
Left Ventricular ◽  
Related Factor ◽  
Nuclear Factor ◽  
Internal Dimension

The purpose of this study was to evaluate the protective effect of swertiamarin on heart failure. To this end, a rat model of heart failure was established via left coronary artery ligation. Infarct size of heart tissues was determined using triphenyl tetrazolium chloride staining. Echocardiography was performed to evaluate cardiac function by the determination of ejection fraction, left ventricular internal dimension in diastole and left ventricular internal dimension in systole. The effect of swertiamarin on oxidative stress was evaluated via enzyme-linked immunosorbent assay. The mechanism was evaluated using western blot. Administration of swertiamarin reduced the infarct size of heart tissues in rat models with heart failure. Moreover, swertiamarin treatment ameliorated the cardiac function, increased ejection fraction and fractional shortening, decreased left ventricular internal dimension in diastole and left ventricular internal dimension in systole. Swertiamarin improved oxidative stress with reduced malondialdehyde, while increased superoxide dismutase, glutathione, and GSH peroxidase. Furthermore, nuclear-factor erythroid 2-related factor 2, heme oxygenase and NAD(P)H dehydrogenase (quinone 1) were elevated by swertiamarin treatment in heart tissues of rat model with heart failure. Swertiamarin alleviated heart failure through suppression of oxidative stress response via nuclear-factor erythroid 2-related factor 2/heme oxygenase-1 pathway providing a novel therapeutic strategy for heart failure.

scholarly journals Association of Lipoprotein (a) variants with risk of cardiovascular disease: a Mendelian randomization study

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Juan Xia ◽  
Chunyue Guo ◽  
Kuo Liu ◽  
Yunyi Xie ◽  
Han Cao ◽  
...  
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Cardiovascular Disease ◽  
Chinese Population ◽  
Left Ventricular Mass Index ◽  
Mendelian Randomization ◽  
Left Ventricular ◽  
Han Chinese ◽  
Han Chinese Population ◽  
Internal Dimension

Abstract Background There is a well-documented empirical relationship between lipoprotein (a) [Lp(a)] and cardiovascular disease (CVD); however, causal evidence, especially from the Chinese population, is lacking. Therefore, this study aims to estimate the causal association between variants in genes affecting Lp(a) concentrations and CVD in people of Han Chinese ethnicity. Methods Two-sample Mendelian randomization analysis was used to assess the causal effect of Lp(a) concentrations on the risk of CVD. Summary statistics for Lp(a) variants were obtained from 1256 individuals in the Cohort Study on Chronic Disease of Communities Natural Population in Beijing, Tianjin and Hebei. Data on associations between single-nucleotide polymorphisms (SNPs) and CVD were obtained from recently published genome-wide association studies. Results Thirteen SNPs associated with Lp(a) levels in the Han Chinese population were used as instrumental variables. Genetically elevated Lp(a) was inversely associated with the risk of atrial fibrillation [odds ratio (OR), 0.94; 95% confidence interval (95%CI), 0.901–0.987; P = 0.012)], the risk of arrhythmia (OR, 0.96; 95%CI, 0.941–0.990; P = 0.005), the left ventricular mass index (OR, 0.97; 95%CI, 0.949–1.000; P = 0.048), and the left ventricular internal dimension in diastole (OR, 0.97; 95%CI, 0.950–0.997; P = 0.028) according to the inverse-variance weighted method. No significant association was observed for congestive heart failure (OR, 0.99; 95% CI, 0.950–1.038; P = 0.766), ischemic stroke (OR, 1.01; 95%CI, 0.981–1.046; P = 0.422), and left ventricular internal dimension in systole (OR, 0.98; 95%CI, 0.960–1.009; P = 0.214). Conclusions This study provided evidence that genetically elevated Lp(a) was inversely associated with atrial fibrillation, arrhythmia, the left ventricular mass index and the left ventricular internal dimension in diastole, but not with congestive heart failure, ischemic stroke, and the left ventricular internal dimension in systole in the Han Chinese population. Further research is needed to identify the mechanism underlying these results and determine whether genetically elevated Lp(a) increases the risk of coronary heart disease or other CVD subtypes.

Abstract 1331: Myocardial Function Alterations Correlate to Cardiac Fibrosis and Upregulation of Profibrotic Signaling in Plasminogen Activator Inhibitor-1 Deficient Mice

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
William Bradham ◽  
Linda Gleaves ◽  
Mousumi Medda ◽  
Douglas Vaughan
Keyword(s):  
Growth Factor ◽  
Plasminogen Activator ◽  
Cardiac Fibrosis ◽  
Plasminogen Activator Inhibitor ◽  
Rt Pcr ◽  
Plasminogen Activator Inhibitor 1 ◽  
Internal Dimension ◽  
Functional Consequences ◽  
Activator Inhibitor ◽  
Pai 1

Cardiac fibrosis is a common sequelae of cardiac injury and has deleterious functional consequences impacting cardiac filling, function and rhythm. Plasminogen activator inhibitor-1 (PAI-1) has been implicated in the pathogenesis of tissue fibrosis in mice. To investigate the longitudinal effect of PAI-1 on cardiac structure and function, M-mode echocardiography was employed to examine cardiac function in PAI-1 deficient (PAI-1 −/− ) and wild-type (WT) control mice in four age groups (6,12,18, 24 months). Eighteen month old PAI-1 −/− mice exhibited reduced left ventricular (LV) diastolic internal dimension ( p =0.0118) and a trend towards increased LV posterior wall (LVPW) thickness, compared to WT. Two year old PAI-1 −/− mice showed increased diastolic and systolic LVPW thickness ( p =0.0127 and p =0.0212, respectively), reduced diastolic and systolic LV internal dimension ( p =0.0486 and p =0.0124), but with preserved LV fractional shortening compared to WT. Histological examination of cardiac sections revealed fibrosis on the anterior epicardial surface of the hearts in 18 month old PKO, which in 26 month old mice had become confluent with extensive (10 –17% by area) epicardial, perivascular, and interstitial distribution (compared to none in WT). Real time polymerase chain reaction (RT-PCR) revealed upregulation of transforming growth factor beta (TGF-β) and fibroblast growth factor 2 in PAI-1 −/− compared to WT ( p =0.0234 and p =0.037, respectively). Immunofluoresence confirmed this finding with bright TGF-β staining localized in the media of intra-myocardial arterioles, and phosphorylated SMAD2/3, the downstream TGF-β signaling mediator, in areas of fibrosis. Thoracic aortic cells from aged (18 –24 month) PKO and WT mice were grown in culture, with RT-PCR revealing 4 fold increased TGF-β and 17 fold increased SMAD3 ( p <0.05 for both) RNA levels in PAI-1 −/− , supplying additional evidence for upregulation of a profibrotic TGF-β/SMAD tissue signaling pathway. The present study is one of the first to elucidate some of the functional consequences and relevant molecular signaling pathways related to aging and PAI-1 deficiency mediated cardiac fibrosis.

scholarly journals Understanding Pashtunwali and the Manifestation of Pashtun Nationalism in Pakistan: A Conceptual Analysis

2019 ◽  
Vol IV (I) ◽  
pp. 264-270
Author(s):  
Surat Khan ◽  
Muhammad Faheem ◽  
Saima Gul
Keyword(s):  
Conceptual Analysis ◽  
State Policies ◽  
Internal Dimension

This paper describes the key elements of Pashtunwali and the manifestation of Pashtun nationalism, especially in Pakistan. This study on Pashtun nationalism finds that Pashtunwali is a centuries-old primordial customary code of life and it is important in the context of nationalism as it strengthens the sentiments and feelings of closeness and affinity; central to the phenomenon of nationalism, among the Pashtuns. This paper also highlights two different aspects of Pashtun nationalism in Pakistan. In the formative phase of Pakistans independence, the stance of Pashtun nationalists was more inclined towards the idea of a separate state for the Pashtuns. However, as a result of various factors; including state policies, currently the manifestation of Pashtun nationalism has adopted the internal dimension of highlighting and struggling for the rights of the Pashtuns in the ambit of the Pakistani constitution and by remaining an integral and constitutional part of the country.

scholarly journals Pakistans Security Dilemma with Afghanistan and India

2019 ◽  
Vol IV (IV) ◽  
pp. 70-77
Author(s):  
Muhammad Tariq ◽  
Arif Khan ◽  
Bakhtiar Khan
Keyword(s):  
National Interest ◽  
Balance Of Power ◽  
Two Dimensions ◽  
Security Dilemma ◽  
Power Theory ◽  
Internal Dimension ◽  
Western Border ◽  
Eastern Border ◽  
External Dimension ◽  
State Relations

Security dilemma plays an important part in determining state relations when particularly they are next door neighbors. In such a condition, it becomes difficult for the states to keep their security protected. Nations have to adopt policies that are beneficial for their national interest. An important function of security dilemma is that it also supports the balance of power theory which helps in balancing and counterbalancing of the countries. As far as, Pakistans security is concerned, it has two dimensions; the internal dimension which has greatly subsided during the present government while external dimension has always been like a Hanging Sword of Damocles. Pakistan is faced with this dilemma on both its eastern and western borders. The eastern border has caused three wars against India while the western border created trouble for Pakistan in the post-9/11 scenario. This paper discusses Pakists security dilemma with Afghanistan and India.

Internet Memes, Memory, and Orders of Repackaging

2021 ◽  
Vol 2 (1) ◽  
pp. 111-136
Author(s):  
Julija Korostenskiene
Keyword(s):  
Human Memory ◽  
Two Dimensions ◽  
The Other ◽  
Methodological Framework ◽  
Internal Dimension ◽  
External Dimension ◽  
The One ◽  
Taxonomic Relations

Abstract The present study explores the construction of humor in internet memes along two dimensions. The external dimension is concerned with humor in internet memes as opposed to verbal humor on the one hand and as opposed to humor in comics and caricatures on the other. The perceptive differences, stemming from the workings of the human memory, and the medium are posited as the two main differentiating factors. On the internal dimension, we explore manifestations of humor in light of the communicative situation and taxonomic relations at both the intermedial and intramedial levels of internet memes, taking as an example a family of You Wouldn’t Get It image macros. Our analysis employs elements of intertextuality theory and the notion of orders of indexicality. The study aims to contribute to the growing theoretical and methodological framework for multifactorial analyses of internet memes.

Theorizing Cultural Models

2019 ◽  
pp. 206-262
Author(s):  
Christian Smith ◽  
Bridget Ritz ◽  
Michael Rotolo
Keyword(s):  
Cultural Models ◽  
Cognitive Anthropology ◽  
Internal Dimension

This chapter reconsiders the post-Parsonian theory of culture by examining the cognitive anthropology school. Here, the internal dimension of culture is understood as most basically cognitively constituted in neurological systems, organized in networks of structurally durable beliefs and schemas, often widely shared by varieties of types of populations, and motivationally directive of action and practices. The chapter focuses on driving home a few limited but crucial points in a larger argument—namely, that culture can be coherent, consensual, reasonable, internalized, and teleological in its orientation to guiding life practices. This is not an argument for a return to Parsonianism, since the chapter's approach is different from that in important ways. Instead, this chapter hopes to advance into a post-post-Parsonian era that corrects the numerous over-reactions and mistakes of the dominant approach of recent decades.

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