Theory Motivated Therapy Studies of SLI

Hallucinogens are a drug class that is growing in popularity with college students. Recent experimental trends, such as microdosing, have helped promote the use of hallucinogens on campus, and students may be tempted to use these substances due to their beliefs about the drugs’ positive effects on mood. Although hallucinogens are not currently an established form of medical therapy, studies have shown that they have significant benefits as adjunctive treatments for psychological disorders. However, the recreational use of these drugs in college students often occurs in uncontrolled doses or with drug mixing, which is often dangerous. Furthermore, students with mental health disorders may have their symptoms masked by hallucinogenic drug use, which could delay treatment and have serious consequences. Long-term use of these drugs may also result in tolerance or hallucinogen persisting perception disorder. This article attempts to review current information regarding hallucinogen use and how it applies to the college population.

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The Effect of Water-Based Therapy Compared to Land-Based Therapy on Balance and Gait Parameters of Patients with Stroke: A Systematic Review

European Neurology ◽

10.1159/000517377 ◽

2021 ◽

pp. 1-9

Author(s):

Nour Zughbor ◽

Aisha Alwahshi ◽

Rahaf Abdelrahman ◽

Zeina Elnekiti ◽

Hoda Elkareish ◽

...

Keyword(s):

Meta Analysis ◽

Berg Balance Scale ◽

Primary Outcome Measure ◽

Balance System ◽

Effect Of Water ◽

Gait Parameters ◽

Water Based ◽

Biodex Balance System ◽

Therapy Studies ◽

The Brain

Introduction: Stroke is defined as the lack of blood supply to the brain, leading to rapid loss of brain function presenting with impairments such as muscle weakness, spasticity, lack of coordination, and proprioception loss. Both hydrotherapy and land-based therapy aim to target these aspects in the process of rehabilitation. The study aims to determine the effectiveness of water-based therapy on balance and gait of patients with stroke compared to land-based therapy. Methods: Data for this review were extracted from databases such as CINAHL, OTseeker, Ovid, PEDro, and PubMed (MEDLINE) and other sources such as Google Scholar. PRISMA guidelines were followed to exclude irrelevant studies. Only randomized controlled trials (RCTs) were included, and methodological quality was assessed using the PEDro scale. A meta-analysis of extracted data was conducted. Results: A total of 16 relevant RCTs were included for the review (n = 412 participants). All RCTs investigated the effect of water-based therapy compared to land-based therapy on balance and gait of patients with stroke. Meta-analysis of studies that used the Berg Balance Scale (BBS) as a primary outcome measure favored land-based therapy. Studies that used the Good Balance System (GBS) and the Biodex Balance System (BioBS) to measure the changes in anteroposterior sway and mediolateral sway favored water-based therapy. The overall pooled effect favored land-based therapy in improving gait parameters. Conclusion: Findings from meta-analysis support the effectiveness of land-based therapy in the improvement of balance and gait parameters of patients with stroke. However, the evidence for water-based therapy continues to be limited, and higher quality studies are required to determine the effectiveness of water-based therapy on patients with stroke, particularly on balance and gait.

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Comments on New Integrative Photomedicine Equipment for Photobiomodulation and COVID-19

Photonics ◽

10.3390/photonics8080303 ◽

2021 ◽

Vol 8 (8) ◽

pp. 303

Author(s):

Gerhard Litscher ◽

Laura Marinela Ailioaie

Keyword(s):

Photodynamic Therapy ◽

Clinical Studies ◽

Research Area ◽

Technical Note ◽

Laser Acupuncture ◽

Home Therapy ◽

Technical Requirements ◽

Scientific Status ◽

Therapy Studies

Up to now it has not yet been scientifically proven whether the technical methods of photonics in the field of photobiomodulation (PBM), photodynamic therapy (PDT), and laser acupuncture in connection with COVID-19 have achieved effective medical success. As part of this short technical note, an overview of the current scientific status is given and new equipment from our own research area is briefly presented. Although there are still many unanswered questions, it seems to be emerging that PBM and PDT in connection with the corresponding photosensitizers may make it appear worthwhile to perform experimental and clinical studies, primarily as so-called home therapy studies. In any case, the technical requirements for this are already in progress.

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MBCL-14. A STUDY OF LOW-DOSE CRANIOSPINAL RADIATION THERAPY IN PATIENTS WITH NEWLY DIAGNOSED AVERAGE-RISK MEDULLOBLASTOMA

Neuro-Oncology ◽

10.1093/neuonc/noaa222.490 ◽

2020 ◽

Vol 22 (Supplement_3) ◽

pp. iii390-iii391

Author(s):

Aaron Mochizuki ◽

Anna Janss ◽

Sonia Partap ◽

Paul Fisher ◽

Yimei Li ◽

...

Keyword(s):

Overall Survival ◽

Radiation Therapy ◽

Treatment Modalities ◽

Average Risk ◽

Craniospinal Radiation ◽

Grade 5 ◽

Therapy Studies ◽

Do So

Abstract INTRODUCTION Medulloblastoma is one of the most common malignant brain tumors in children. To date, the treatment of average-risk (non-metastatic, completely resected) medulloblastoma includes craniospinal radiation therapy and adjuvant chemotherapy. Modern treatment modalities and now risk stratification of subgroups have extended the survival of these patients, exposing the long-term morbidities associated with radiation therapy. METHODS We performed a single-arm, multi-institution study, seeking to reduce the late effects of treatment in patients with average-risk medulloblastoma prior to advances in molecular subgrouping. To do so, we reduced the dose of craniospinal irradiation by 25% to 18 gray with the goal of maintaining the therapeutic efficacy as described in CCG 9892 with maintenance chemotherapy. RESULTS 28 patients aged 3–30 years were enrolled across three institutions between April 2001 and December 2010. Median age at enrollment was 9 years with a median follow-up time of 11.7 years. The 3-year relapse-free (RFS) and overall survival (OS) were 78.6% (95% CI 58.4% to 89.8%) and 92.9% (95% CI 74.4% to 98.2%), respectively. The 5-year RFS and OS were 71.4% (95% CI 50.1% to 84.6%) and 85.7% (95% CI 66.3% to 94.4%), respectively. Toxicities were similar to those seen in other studies; there were no grade 5 toxicities. CONCLUSIONS Given the known neurocognitive adverse effects associated with cranial radiation therapy, studies to evaluate the feasibility of dose reduction are needed. In this study, we demonstrate that select patients with average-risk medulloblastoma may benefit from reduced craniospinal radiation dose of 18 gray without impacting relapse-free or overall survival.

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A Call for Standardization in Cell Therapy Studies

The Journal of Bone and Joint Surgery (American) ◽

10.2106/jbjs.19.00189 ◽

2019 ◽

Vol 101 (10) ◽

pp. e47

Author(s):

Scott A. Rodeo

Keyword(s):

Cell Therapy ◽

Therapy Studies

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The Clinical Use of Denosumab for the Management of Low Bone Mineral Density in Postmenopausal Women

Journal of Pharmacy Practice ◽

10.1177/0897190012442061 ◽

2012 ◽

Vol 25 (3) ◽

pp. 310-318 ◽

Cited By ~ 4

Author(s):

Kira B. Harris ◽

Kimberly L. Nealy ◽

Delilah J. Jackson ◽

Phillip L. Thornton

Keyword(s):

Bone Mineral Density ◽

Postmenopausal Women ◽

Bone Mineral ◽

Hip Fractures ◽

Nuclear Factor Κb ◽

Bisphosphonate Therapy ◽

Mineral Density ◽

Osteoporosis Therapy ◽

Cost Of Health Care ◽

Therapy Studies

Osteoporosis is a leading cause of debility and declining quality of life in postmenopausal women worldwide. Treatment of osteoporosis has been ubiquitous throughout the developed world since the mid-1990s, most notably with the introduction of bisphosphonates in 1995. Nonetheless, the incidence of hip fractures increased by 25% between 1990 and 2000, despite advances in osteoporosis therapy. Studies indicate that bone density increases over the first 3 years of bisphosphonate therapy and then plateaus or perhaps even declines, placing these patients at greater risk of fracture. Since hip fractures are associated with increased morbidity, mortality, and increased cost of health care, improvements in treating osteoporosis are critical. Denosumab is a novel monoclonal antibody targeted against the receptor activator of nuclear factor-κB ligand (RANKL) that inhibits osteoclast activity. Initial data suggest that denosumab increases bone mineral density for greater than 3 years. Of greater importance, denosumab has been shown to decrease vertebral fractures by 68%, nonvertebral fractures by 19%, and hip fractures by 42% for at least 36 months. Data also indicate that the safety profile of denosumab is equivalent to other drugs used in osteoporosis management, but potential risks of immunosuppression and cancer have been hypothesized.

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Cirrhosis in rats does not resolve in the long-term after induction by thioacetamide model

Journal of Morphological Sciences ◽

10.4322/jms.ao060313 ◽

2014 ◽

Vol 31 (01) ◽

pp. 033-041

Author(s):

L. Rui ◽

E. Silva ◽

T. Silva ◽

T. Portela ◽

A. Silva ◽

...

Keyword(s):

Biochemical Analysis ◽

Hepatic Cirrhosis ◽

Activity Index ◽

Experimental Period ◽

Female Wistar Rats ◽

Serum Biochemical ◽

Histological Activity ◽

Therapy Studies ◽

Future Therapy

Abstract Introductions: Hepatic cirrhosis is a final common pathway of all chronic liver diseases, characterized by deposit of fibrillar collagen and liver failure. Materials and Methods: In this experiment, hepatic cirrhosis was induced in 15 female Wistar rats by a 14-week period, with thioacetamide solution in a 200 mg/kg dosage, via intraperitoneal. Animals were submitted to liver biopsy, and euthanized after a 80-day post-induction period. Serum biochemical analysis was performed, in addition to histopathology by H.E., Picrosirius, Alcian Blue and P.A.S. stainings, following analysis of histological activity index and staging of fibrosis. Morphometric analysis of collagen on Picrosirius slides was also performed. Results: Mortality during experimental period was low (13.33%), and after 80-day period, liver function improved, cellular changes did not altered, and deposition of acidic mucopolysaccharides and glycogen were increased. Liver histological activity did not change significantly (7.25 ± 1.30 to 6.41 ± 1.32), but staging of fibrosis was altered (3.91 ± 0.76 to 4.70 ± 1.11). Interlobular collagen showed a significant decrease (5.14 ± 2.00 to 4.00 ± 1.20), while intralobular collagen was increased (0.23 ± 0.06 to 0.36 ± 0.08). Conclusions: These findings characterize thioacetamide as a safe experimental model for induction cirrhosis, which may be used for future therapy studies.

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