Images of shadowing and interpreting

Interpreting ◽  
2000 ◽  
Vol 5 (2) ◽  
pp. 147-167 ◽  
Author(s):  
Jorma Tommola ◽  
Matti Laine ◽  
Marianna Sunnari ◽  
Juha O. Rinne

We begin by noting that, in addition to the more or less established trends of cognitive modelling and neurolinguistic or behavioural experimentation, a more recent orientation in research on interpreting (IR) as a complex cognitive process is functional neuroimaging. We then describe current brain imaging methods — electroencephalography, magnetoencephalography, positron emission tomography, functional magnetic resonance imaging, and near-infrared spectroscopy — and provide selected examples of their use in language processing and interpreting research, accompanied with brief evaluations of their applicability for IR. In spite of limitations related to invasiveness, temporal resolution, and experimental design, positron emission tomography (PET) is potentially the strongest tool for investigations of the neural substrates of ongoing interpreting performance. Finally, we describe what we believe is the first published study of speech shadowing and professional simultaneous interpreting using PET. Shadowing of the non-dominant language produces more extensive activations in the temporal cortex and motor regions than shadowing of the dominant language, which suggests that even in the simultaneous repetition task, the less automatized language recruits more neural resources. Simultaneous interpreting, whether into the dominant or into the non-dominant language, predominantly activates left-hemispheric structures. Activation patterns are, however, clearly modulated by the direction of interpreting, with more extensive activation during interpreting into the non-dominant language.

Author(s):  
Saugat Bhattacharyya ◽  
Anwesha Khasnobish ◽  
Poulami Ghosh ◽  
Ankita Mazumder ◽  
D. N. Tibarewala

Evolution has endowed human race with the most adroit brain, and to harness its potential to the fullest the concept of brain computer interface (BCI) has emerged. One of the most crucial components of BCI is the technique of brain imaging. The first approach in the field of brain imaging was to measure the electrical and magnetic activity of the brain, the techniques being known as Electroencephalography and Magnetoencephalography. Striving for furtherance, researchers came up with another alternative known as Magnetic Resonance Imaging. But it being confined to only structural imaging, the functional aspects of brain were mapped using functional magnetic resonance imaging. A similar but comparatively newer neuroimaging modality is Functional Near Infrared Spectroscopy. Transcranial Magnetic Stimulation neuro-physiological technique is based on the principle of electromagnetic induction. Based on nuclear medicine the brain imaging technologies that are widely explored in the world of BCI are Positron Emission Tomography and Single Positron Emission Tomography.


Author(s):  
Matthias Nahrendorf ◽  
Friedrich Felix Hoyer ◽  
Anu E. Meerwaldt ◽  
Mandy M.T. van Leent ◽  
Max L. Senders ◽  
...  

Background: Macrophages, innate immune cells that reside in all organs, defend the host against infection and injury. In the heart and vasculature, inflammatory macrophages also enhance tissue damage and propel cardiovascular diseases. Methods: We here use in vivo positron emission tomography (PET) imaging, flow cytometry, and confocal microscopy to evaluate quantitative noninvasive assessment of cardiac, arterial, and pulmonary macrophages using the nanotracer 64 Cu-Macrin—a 20-nm spherical dextran nanoparticle assembled from nontoxic polyglucose. Results: PET imaging using 64 Cu-Macrin faithfully reported accumulation of macrophages in the heart and lung of mice with myocardial infarction, sepsis, or pneumonia. Flow cytometry and confocal microscopy detected the near-infrared fluorescent version of the nanoparticle ( VT680 Macrin) primarily in tissue macrophages. In 5-day-old mice, 64 Cu-Macrin PET imaging quantified physiologically more numerous cardiac macrophages. Upon intravenous administration of 64 Cu-Macrin in rabbits and pigs, we detected heightened macrophage numbers in the infarcted myocardium, inflamed lung regions, and atherosclerotic plaques using a clinical PET/magnetic resonance imaging scanner. Toxicity studies in rats and human dosimetry estimates suggest that 64 Cu-Macrin is safe for use in humans. Conclusions: Taken together, these results indicate 64 Cu-Macrin could serve as a facile PET nanotracer to survey spatiotemporal macrophage dynamics during various physiological and pathological conditions. 64 Cu-Macrin PET imaging could stage inflammatory cardiovascular disease activity, assist disease management, and serve as an imaging biomarker for emerging macrophage-targeted therapeutics.


2018 ◽  
Vol 40 (2) ◽  
pp. 328-340 ◽  
Author(s):  
Harmke A Polinder-Bos ◽  
Jan Willem J Elting ◽  
Marcel JH Aries ◽  
David Vállez García ◽  
Antoon TM Willemsen ◽  
...  

Near-infrared spectroscopy (NIRS) is used to monitor cerebral tissue oxygenation (rSO2) depending on cerebral blood flow (CBF), cerebral blood volume and blood oxygen content. We explored whether NIRS might be a more easy applicable proxy to [15O]H2O positron emission tomography (PET) for detecting CBF changes during hemodialysis. Furthermore, we compared potential determinants of rSO2 and CBF. In 12 patients aged ≥ 65 years, NIRS and PET were performed simultaneously: before (T1), early after start (T2), and at the end of hemodialysis (T3). Between T1 and T3, the relative change in frontal rSO2 (ΔrSO2) was −8 ± 9% ( P = 0.001) and −5 ± 11% ( P = 0.08), whereas the relative change in frontal gray matter CBF (ΔCBF) was −11 ± 18% ( P = 0.009) and −12 ± 16% ( P = 0.007) for the left and right hemisphere, respectively. ΔrSO2 and ΔCBF were weakly correlated for the left (ρ 0.31, P = 0.4), and moderately correlated for the right (ρ 0.69, P = 0.03) hemisphere. The Bland-Altman plot suggested underestimation of ΔCBF by NIRS. Divergent associations of pH, pCO2 and arterial oxygen content with rSO2 were found compared to corresponding associations with CBF. In conclusion, NIRS could be a proxy to PET to detect intradialytic CBF changes, although NIRS and PET capture different physiological parameters of the brain.


2013 ◽  
Vol 91 (10) ◽  
pp. 1363-1370 ◽  
Author(s):  
Masayuki Kobayashi ◽  
Yilong Cui ◽  
Takeo Sako ◽  
Tetsuya Sasabe ◽  
Naoko Mizoguchi ◽  
...  

2017 ◽  
Vol 2 (3) ◽  
Author(s):  
Chiara Luppi ◽  
Francesca Santagata ◽  
Margherita Marchetti ◽  
Giuliana Bottignole ◽  
Pasqualina Sapone ◽  
...  

Musical hallucinations are an uncommon type of auditory hallucinations, they widely occur in elderly. Our group analyzed medical history, pharmacological therapy, neuropsychological pattern, audiometric testing, electroencephalogram, cerebral magnetic resonance and cerebral fludeoxyglucose-positron emission tomography (FDG-PET) of two patients. FDGPET showed in both patients hypometabolism pronounced in posterior regions. In particular the medial-inferior temporal cortex and the occipital associative areas were affected. Moreover, neuropsychological pattern suggested a visuospatial-executive deficit, conformed to the occipital involvement. Our reported cases might suggest that musical hallucinations have been arisen from a combination of peripheral and central dysfunction. A further explanation might be that musical hallucinations result from multiple white matter lacunar lesions due to small vascular events. A question is whether musical hallucinations might be primarily associated with occipital areas hypometabolism and visuospatial alterations typically associated with Levy body dementia (LBD).


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