scholarly journals Lesion Bypass ofN2-Ethylguanine by Human DNA Polymerase ι

2008 ◽  
Vol 284 (3) ◽  
pp. 1732-1740 ◽  
Author(s):  
Matthew G. Pence ◽  
Patrick Blans ◽  
Charles N. Zink ◽  
Thomas Hollis ◽  
James C. Fishbein ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Lesion Bypass ◽  
Human Dna ◽  
Dna Polymerase Ι

scholarly journals Human DNA Polymerase ι Incorporates dCTP Opposite Template G via a G.C+ Hoogsteen Base Pair

Structure ◽  
2005 ◽  
Vol 13 (10) ◽  
pp. 1569-1577 ◽  
Author(s):  
Deepak T. Nair ◽  
Robert E. Johnson ◽  
Louise Prakash ◽  
Satya Prakash ◽  
Aneel K. Aggarwal
Keyword(s):  
Dna Polymerase ◽  
Base Pair ◽  
Human Dna ◽  
Dna Polymerase Ι

Response of human DNA polymerase ι promoter to N-methyl-N′-nitro-N-nitrosoguanidine

2010 ◽  
Vol 29 (1) ◽  
pp. 79-86 ◽  
Author(s):  
Huifang Zhu ◽  
Yanfeng Fan ◽  
Hongjuan Jiang ◽  
Jing Shen ◽  
Hongyan Qi ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Human Dna ◽  
Dna Polymerase Ι

scholarly journals Accuracy of lesion bypass by yeast and human DNA polymerase  

2001 ◽  
Vol 98 (15) ◽  
pp. 8355-8360 ◽  
Author(s):  
M. T. Washington ◽  
R. E. Johnson ◽  
L. Prakash ◽  
S. Prakash
Keyword(s):  
Dna Polymerase ◽  
Lesion Bypass ◽  
Human Dna

Replication by human DNA polymerase-ι occurs by Hoogsteen base-pairing

Nature ◽  
2004 ◽  
Vol 430 (6997) ◽  
pp. 377-380 ◽  
Author(s):  
Deepak T. Nair ◽  
Robert E. Johnson ◽  
Satya Prakash ◽  
Louise Prakash ◽  
Aneel K. Aggarwal
Keyword(s):  
Dna Polymerase ◽  
Base Pairing ◽  
Human Dna ◽  
Hoogsteen Base Pairing ◽  
Dna Polymerase Ι

scholarly journals Proofreading exonuclease activity of human DNA polymerase δ and its effects on lesion-bypass DNA synthesis

2009 ◽  
Vol 37 (9) ◽  
pp. 2854-2866 ◽  
Author(s):  
Ruzaliya Fazlieva ◽  
Cynthia S. Spittle ◽  
Darlene Morrissey ◽  
Harutoshi Hayashi ◽  
Hong Yan ◽  
...  
Keyword(s):  
Dna Synthesis ◽  
Dna Polymerase ◽  
Exonuclease Activity ◽  
Lesion Bypass ◽  
Dna Polymerase Δ ◽  
Human Dna

scholarly journals Human DNA Polymerase ι Promotes Replication through a Ring-Closed Minor-Groove Adduct That Adopts a syn Conformation in DNA

2005 ◽  
Vol 25 (19) ◽  
pp. 8748-8754 ◽  
Author(s):  
William T. Wolfle ◽  
Robert E. Johnson ◽  
Irina G. Minko ◽  
R. Stephen Lloyd ◽  
Satya Prakash ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Dna Polymerases ◽  
Minor Groove ◽  
Dna Lesions ◽  
Unsaturated Aldehyde ◽  
Cyclic Form ◽  
Human Dna ◽  
A Minor ◽  
Dna Polymerase Ι

ABSTRACT Acrolein, an α,β-unsaturated aldehyde, is generated in vivo as the end product of lipid peroxidation and from oxidation of polyamines. The reaction of acrolein with the N 2 group of guanine in DNA leads to the formation of a cyclic adduct, γ-hydroxy-1,N 2-propano-2′-deoxyguanosine (γ-HOPdG). Previously, we have shown that proficient replication through the γ-HOPdG adduct can be mediated by the sequential action of human DNA polymerases (Pols) ι and κ, in which Polι incorporates either pyrimidine opposite γ-HOPdG, but Polκ extends only from the cytosine. Since γ-HOPdG can adopt either a ring-closed cyclic form or a ring-opened form in DNA, to better understand the mechanisms that Pols ι and κ employ to promote replication through this lesion, we have examined the ability of these polymerases to replicate through the structural analogs of γ-HOPdG that are permanently either ring closed or ring opened. Our studies with these model adducts show that whereas the ring-opened form of γ-HOPdG is not inhibitory to synthesis by human Pols η, ι, or κ, only Polι is able to incorporate nucleotides opposite the ring-closed form, which is known to adopt a syn conformation in DNA. From these studies, we infer that (i) Pols η, ι, and κ have the ability to proficiently replicate through minor-groove DNA lesions that do not perturb the Watson-Crick hydrogen bonding of the template base with the incoming nucleotide, and (ii) Polι can accommodate a minor-groove-adducted template purine which adopts a syn conformation in DNA and forms a Hoogsteen base pair with the incoming nucleotide.

Human DNA polymerase λ catalyzes lesion bypass across benzo[a]pyrene-derived DNA adduct during base excision repair

DNA Repair ◽  
2012 ◽  
Vol 11 (4) ◽  
pp. 367-373 ◽  
Author(s):  
Lidia V. Skosareva ◽  
Natalia A. Lebedeva ◽  
Nadejda I. Rechkunova ◽  
Alexander Kolbanovskiy ◽  
Nicholas E. Geacintov ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Dna Adduct ◽  
Lesion Bypass ◽  
Human Dna ◽  
Dna Polymerase Λ ◽  
Base Excision

scholarly journals Structural Basis for Proficient Incorporation of dTTP OppositeO6-Methylguanine by Human DNA Polymerase ι

2010 ◽  
Vol 285 (52) ◽  
pp. 40666-40672 ◽  
Author(s):  
Matthew G. Pence ◽  
Jeong-Yun Choi ◽  
Martin Egli ◽  
F. Peter Guengerich
Keyword(s):  
Dna Polymerase ◽  
Structural Basis ◽  
Human Dna ◽  
Dna Polymerase Ι
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