scholarly journals Bidirectional Regulation of Kainate Receptor Surface Expression in Hippocampal Neurons

2008 ◽  
Vol 283 (52) ◽  
pp. 36435-36440 ◽  
Author(s):  
Stéphane Martin ◽  
Tristan Bouschet ◽  
Emma L. Jenkins ◽  
Atsushi Nishimune ◽  
Jeremy M. Henley
Keyword(s):  
Hippocampal Neurons ◽  
Surface Expression ◽  
Kainate Receptor ◽  
Bidirectional Regulation ◽  
Receptor Surface Expression

scholarly journals Sustained postsynaptic kainate receptor activation downregulates AMPA receptor surface expression and induces hippocampal LTD

2020 ◽  
Author(s):  
Jithin D. Nair ◽  
Ellen Braksator ◽  
Busra P Yucel ◽  
Richard Seager ◽  
Jack R. Mellor ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Ampa Receptors ◽  
Hippocampal Neurons ◽  
Hippocampal Slices ◽  
Surface Expression ◽  
Receptor Activation ◽  
Kainate Receptors ◽  
Receptor Surface Expression ◽  
Acute Hippocampal Slices

AbstractHere we report that sustained activation of GluK2 subunit-containing kainate receptors leads to AMPA receptor endocytosis and a novel form of long-term depression (KAR-LTDAMPAR) in hippocampal neurons. The KAR-evoked loss of surface AMPA receptors requires KAR channel activity and is occluded by the blockade of PKC or PKA. Moreover, in acute hippocampal slices, kainate invoked LTD of AMPA EPSCs. These data, together with our previously reported KAR-LTPAMPAR, demonstrate that KARs bidirectionally regulate synaptic AMPARs and synaptic plasticity.

REGULATION OF AMPA RECEPTOR SURFACE EXPRESSION BY A NSF-DEPENDENT MECHANISM IN HIPPOCAMPAL NEURONS IN CULTURE

1999 ◽  
Vol 27 (3) ◽  
pp. A117-A117
Author(s):  
J. Noel ◽  
G. Scott Ralph ◽  
L. Pickard ◽  
E. Molnar ◽  
J. B. Uney ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Hippocampal Neurons ◽  
Surface Expression ◽  
Receptor Surface Expression ◽  
Dependent Mechanism

scholarly journals SUMOylation Is Required for Glycine-Induced Increases in AMPA Receptor Surface Expression (ChemLTP) in Hippocampal Neurons

PLoS ONE ◽  
2013 ◽  
Vol 8 (1) ◽  
pp. e52345 ◽  
Author(s):  
Nadia Jaafari ◽  
Filip A. Konopacki ◽  
Thomas F. Owen ◽  
Sriharsha Kantamneni ◽  
Philip Rubin ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Hippocampal Neurons ◽  
Surface Expression ◽  
Receptor Surface Expression

scholarly journals Sustained postsynaptic kainate receptor activation downregulates AMPA receptor surface expression and induces hippocampal LTD

iScience ◽  
2021 ◽  
pp. 103029
Author(s):  
Jithin D. Nair ◽  
Ellen Braksator ◽  
Busra P. Yucel ◽  
Alexandra Fletcher-Jones ◽  
Richard Seager ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Surface Expression ◽  
Receptor Activation ◽  
Kainate Receptor ◽  
Receptor Surface Expression

GRASP1 ubiquitination regulates AMPA receptor surface expression and synaptic activity in cultured hippocampal neurons

2021 ◽  
Vol 35 (8) ◽  
Author(s):  
Miranda Mele ◽  
Pasqualino De Luca ◽  
Ana Rita Santos ◽  
Marta Vieira ◽  
Ivan L. Salazar ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Hippocampal Neurons ◽  
Surface Expression ◽  
Synaptic Activity ◽  
Receptor Surface Expression ◽  
Cultured Hippocampal Neurons

scholarly journals The C-terminal helix 9 motif in rat cannabinoid receptor type 1 regulates axonal trafficking and surface expression

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Alexandra Fletcher-Jones ◽  
Keri L Hildick ◽  
Ashley J Evans ◽  
Yasuko Nakamura ◽  
Kevin A Wilkinson ◽  
...  
Keyword(s):  
Hippocampal Neurons ◽  
Secretory Pathway ◽  
Cannabinoid Receptor ◽  
Surface Expression ◽  
Surface Polarity ◽  
Time Resolved ◽  
Surface Stability ◽  
C Terminus ◽  
Time Resolved Imaging ◽  
Dual Mechanism

Cannabinoid type one receptor (CB1R) is only stably surface expressed in axons, where it downregulates neurotransmitter release. How this tightly regulated axonal surface polarity is established and maintained is unclear. To address this question, we used time-resolved imaging to determine the trafficking of CB1R from biosynthesis to mature polarised localisation in cultured rat hippocampal neurons. We show that the secretory pathway delivery of CB1R is axonally biased and that surface expressed CB1R is more stable in axons than in dendrites. This dual mechanism is mediated by the CB1R C-terminus and involves the Helix 9 (H9) domain. Removal of the H9 domain increases secretory pathway delivery to dendrites and decreases surface stability. Furthermore, CB1RΔH9 is more sensitive to agonist-induced internalisation and less efficient at downstream signalling than CB1RWT. Together, these results shed new light on how polarity of CB1R is mediated and indicate that the C-terminal H9 domain plays key roles in this process.

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