REGULATION OF AMPA RECEPTOR SURFACE EXPRESSION BY A NSF-DEPENDENT MECHANISM IN HIPPOCAMPAL NEURONS IN CULTURE

1999 ◽  
Vol 27 (3) ◽  
pp. A117-A117
Author(s):  
J. Noel ◽  
G. Scott Ralph ◽  
L. Pickard ◽  
E. Molnar ◽  
J. B. Uney ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Hippocampal Neurons ◽  
Surface Expression ◽  
Receptor Surface Expression ◽  
Dependent Mechanism

scholarly journals Sustained postsynaptic kainate receptor activation downregulates AMPA receptor surface expression and induces hippocampal LTD

2020 ◽  
Author(s):  
Jithin D. Nair ◽  
Ellen Braksator ◽  
Busra P Yucel ◽  
Richard Seager ◽  
Jack R. Mellor ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Ampa Receptors ◽  
Hippocampal Neurons ◽  
Hippocampal Slices ◽  
Surface Expression ◽  
Receptor Activation ◽  
Kainate Receptors ◽  
Receptor Surface Expression ◽  
Acute Hippocampal Slices

AbstractHere we report that sustained activation of GluK2 subunit-containing kainate receptors leads to AMPA receptor endocytosis and a novel form of long-term depression (KAR-LTDAMPAR) in hippocampal neurons. The KAR-evoked loss of surface AMPA receptors requires KAR channel activity and is occluded by the blockade of PKC or PKA. Moreover, in acute hippocampal slices, kainate invoked LTD of AMPA EPSCs. These data, together with our previously reported KAR-LTPAMPAR, demonstrate that KARs bidirectionally regulate synaptic AMPARs and synaptic plasticity.

scholarly journals SUMOylation Is Required for Glycine-Induced Increases in AMPA Receptor Surface Expression (ChemLTP) in Hippocampal Neurons

PLoS ONE ◽  
2013 ◽  
Vol 8 (1) ◽  
pp. e52345 ◽  
Author(s):  
Nadia Jaafari ◽  
Filip A. Konopacki ◽  
Thomas F. Owen ◽  
Sriharsha Kantamneni ◽  
Philip Rubin ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Hippocampal Neurons ◽  
Surface Expression ◽  
Receptor Surface Expression

GRASP1 ubiquitination regulates AMPA receptor surface expression and synaptic activity in cultured hippocampal neurons

2021 ◽  
Vol 35 (8) ◽  
Author(s):  
Miranda Mele ◽  
Pasqualino De Luca ◽  
Ana Rita Santos ◽  
Marta Vieira ◽  
Ivan L. Salazar ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Hippocampal Neurons ◽  
Surface Expression ◽  
Synaptic Activity ◽  
Receptor Surface Expression ◽  
Cultured Hippocampal Neurons

scholarly journals Surface Expression of AMPA Receptors in Hippocampal Neurons Is Regulated by an NSF-Dependent Mechanism

Neuron ◽  
1999 ◽  
Vol 23 (2) ◽  
pp. 365-376 ◽  
Author(s):  
Jacques Noel ◽  
G.Scott Ralph ◽  
Lisa Pickard ◽  
Jackie Williams ◽  
Elek Molnar ◽  
...  
Keyword(s):  
Ampa Receptors ◽  
Hippocampal Neurons ◽  
Surface Expression ◽  
Dependent Mechanism

scholarly journals Bidirectional Regulation of Kainate Receptor Surface Expression in Hippocampal Neurons

2008 ◽  
Vol 283 (52) ◽  
pp. 36435-36440 ◽  
Author(s):  
Stéphane Martin ◽  
Tristan Bouschet ◽  
Emma L. Jenkins ◽  
Atsushi Nishimune ◽  
Jeremy M. Henley
Keyword(s):  
Hippocampal Neurons ◽  
Surface Expression ◽  
Kainate Receptor ◽  
Bidirectional Regulation ◽  
Receptor Surface Expression
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