scholarly journals A High Affinity Hepatocyte Growth Factor-binding Site in the Immunoglobulin-like Region of Met

2008 ◽  
Vol 283 (30) ◽  
pp. 21267-21277 ◽  
Author(s):  
Cristina Basilico ◽  
Addolorata Arnesano ◽  
Maria Galluzzo ◽  
Paolo M. Comoglio ◽  
Paolo Michieli
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Binding Site ◽  
Factor Binding Site ◽  
Factor Binding ◽  
High Affinity ◽  
Hepatocyte Growth

Isolation and Conformational Analysis of Fragment Peptide Corresponding to the Heparin-Binding Site of Hepatocyte Growth Factor

Biochemistry ◽  
1997 ◽  
Vol 36 (33) ◽  
pp. 10286-10291 ◽  
Author(s):  
Hideyuki Aoyama ◽  
Daiji Naka ◽  
Yoshiko Yoshiyama ◽  
Takehisa Ishii ◽  
Jun Kondo ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Conformational Analysis ◽  
Binding Site ◽  
Heparin Binding ◽  
Heparin Binding Site ◽  
Hepatocyte Growth

scholarly journals High-Affinity Nod Factor Binding Site from Phaseolus vulgaris Cell Suspension Cultures

2002 ◽  
Vol 15 (8) ◽  
pp. 834-839 ◽  
Author(s):  
Frédéric Gressent ◽  
Natacha Mantegazza ◽  
Julie V. Cullimore ◽  
Hugues Driguez ◽  
Raoul Ranjeva ◽  
...  
Keyword(s):  
Phaseolus Vulgaris ◽  
Binding Site ◽  
Acyl Chain ◽  
Minor Role ◽  
Nod Factors ◽  
Nod Factor ◽  
Factor Binding Site ◽  
Factor Binding ◽  
High Affinity ◽  
Perception System

The lipo-chitooligosaccharidic Nod factors produced by rhizobia are key molecules in the establishment of symbiosis with legumes and probably are recognized by the host plant via specific receptors. Here, we report on the presence of a binding site in cell cultures of Phaseolus vulgaris displaying a high affinity for Nod factors from Rhizobium tropici (NodRt-V) (Me, S, C18:1), a symbiont of this legume. The binding site shares common properties with NFBS2, a Nod-factor binding site previously characterised in Medicago varia, in terms of affinity, preferential plasma-membrane location, and sensitivity to proteases and lysine reactive reagents. However, the bean site poorly recognizes the Nod factors produced by Sinorhizobium meliloti, the symbiont of Medicago. The study of selectivity toward the Nod factors reveals that the length and degree of unsaturation of the acyl chain and the length of the oligosaccharidic moiety are important determinants of high affinity binding to the bean site; whereas, the N-methyl and O-sulfuryl groups play a minor role. Thus, the common characteristics of P. vulgaris and M. varia Nod-factor binding sites suggest that they probably correspond to structurally related proteins, but their different selectivity suggests that they may be involved in a differential perception system for Nod factors in legumes.

scholarly journals Aegyptin displays high-affinity for the von Willebrand factor binding site (RGQOGVMGF) in collagen and inhibits carotid thrombus formation in vivo

FEBS Journal ◽  
2009 ◽  
Vol 277 (2) ◽  
pp. 413-427 ◽  
Author(s):  
Eric Calvo ◽  
Fuyuki Tokumasu ◽  
Daniella M. Mizurini ◽  
Peter McPhie ◽  
David L. Narum ◽  
...  
Keyword(s):  
Binding Site ◽  
Von Willebrand Factor ◽  
Thrombus Formation ◽  
Factor Binding Site ◽  
Factor Binding ◽  
High Affinity ◽  
Von Willebrand ◽  
Willebrand Factor

Immunoglobulin-like domains define the nerve growth factor binding site of the TrkA receptor

1997 ◽  
Vol 15 (7) ◽  
pp. 668-672 ◽  
Author(s):  
Paul H. Holden ◽  
Vipin Asopa ◽  
Alan G.S. Robertson ◽  
Anthony R. Clarke ◽  
Sue Tyler ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Binding Site ◽  
Trka Receptor ◽  
Nerve Growth ◽  
Factor Binding Site ◽  
Factor Binding

scholarly journals The solution structure of the N-terminal domain of hepatocyte growth factor reveals a potential heparin-binding site

Structure ◽  
1998 ◽  
Vol 6 (1) ◽  
pp. 109-116 ◽  
Author(s):  
Hongjun Zhou ◽  
Marie J Mazzulla ◽  
Joshua D Kaufman ◽  
Stephen J Stahl ◽  
Paul T Wingfield ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Binding Site ◽  
Solution Structure ◽  
Heparin Binding ◽  
Terminal Domain ◽  
Heparin Binding Site ◽  
Hepatocyte Growth

scholarly journals Identification and Dynamics of a Heparin-Binding Site in Hepatocyte Growth Factor†

Biochemistry ◽  
1999 ◽  
Vol 38 (45) ◽  
pp. 14793-14802 ◽  
Author(s):  
Hongjun Zhou ◽  
José R. Casas-Finet ◽  
R. Heath Coats ◽  
Joshua D. Kaufman ◽  
Stephen J. Stahl ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Binding Site ◽  
Heparin Binding ◽  
Heparin Binding Site ◽  
Hepatocyte Growth
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