scholarly journals The Critical Role of Substrate-Protein Hydrogen Bonding in the Control of Regioselective Hydroxylation in P450cin

2008 ◽  
Vol 283 (16) ◽  
pp. 10804-10812 ◽  
Author(s):  
Yergalem T. Meharenna ◽  
Kate E. Slessor ◽  
Sonia M. Cavaignac ◽  
Thomas L. Poulos ◽  
James J. De Voss
Keyword(s):  
Hydrogen Bonding ◽  
Critical Role ◽  
Substrate Protein ◽  
Regioselective Hydroxylation

scholarly journals A Critical Role of Ser26 Hydrogen Bonding in Aβ42 Assembly and Toxicity

Biochemistry ◽  
2017 ◽  
Vol 56 (48) ◽  
pp. 6321-6324 ◽  
Author(s):  
Robin Roychaudhuri ◽  
Tien-Phat V. Huynh ◽  
Taylor R. Whitaker ◽  
Elisabeth Hodara ◽  
Margaret M. Condron ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Critical Role

scholarly journals Unnatural Amino Acid Mutagenesis Reveals the Critical Role of Hydrogen Bonding for Binding of Retigabine in the Pore of KCNQ Channels

2014 ◽  
Vol 106 (2) ◽  
pp. 143a
Author(s):  
Stephan A. Pless ◽  
Michael Yau ◽  
Jason D. Galpin ◽  
Christopher A. Ahern ◽  
Harley T. Kurata
Keyword(s):  
Hydrogen Bonding ◽  
Amino Acid ◽  
Critical Role ◽  
Unnatural Amino Acid ◽  
Kcnq Channels ◽  
Unnatural Amino Acid Mutagenesis ◽  
Amino Acid Mutagenesis

Impact of Ubiquitination Signaling Pathway Modifications on Oral Carcinoma

2022 ◽  
Vol 2 (1) ◽  
pp. 1-6
Author(s):  
EFTHIMIOS KYRODIMOS ◽  
ARISTEIDIS CHRYSOVERGIS ◽  
NICHOLAS MASTRONIKOLIS ◽  
EVANGELOS TSIAMBAS ◽  
LOUKAS MANAIOS ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Broad Spectrum ◽  
Critical Role ◽  
Ubiquitin Proteasome System ◽  
Protein Targets ◽  
Metabolism Regulation ◽  
Substrate Protein ◽  
Ubiquitin Proteasome ◽  
Ubiquitin Conjugation

Among intra-cellular homeostasis mechanisms, ubiquitination plays a critical role in protein metabolism regulation by degrading proteins via activating a broad spectrum of ubiquitin chains. In fact, ubiquitination and sumoylation signaling pathways are characterized by increased complexity regarding the molecules and their interactions. The Ubiquitin-Proteasome System (Ub-PS) recognizes and targets a broad spectrum of protein substrates. Ubiquitin conjugation modifies each substrate protein determining its biochemical fate (degradation). A major functional activity of Ub-PS is autophagy mechanism regulation. Interestingly, Ub-PS promotesall stages of bulk autophagy (initiation, execution, and termination). Autophagy is a crucial catabolic process that provides protein degradation and for this reason the interaction with Ub-PS is crucial. Furthermore, ubiquitination controls and regulates specific types of protein targets. Ub-PS is also involved in oxidative cellular stress and DNA damage response. Additionally, the functional role of Ub-PS in ribosome machinery regulation seems to be crucial. Concerning carcinogenesis, Ub-PS is involved in malignant disease development and progression by negatively affecting the corresponding TGF-B-, MEEK/MAPK/ERK-JNK- dependent signaling pathways. In the current review article, we describe the role of Ub-PSbiochemicalmodifications and alterations in oral squamous cell carcinoma (OSCC).

scholarly journals Structures of furanosides: geometrical analysis of low-temperature X-ray and neutron crystal structures of five crystalline methyl pentofuranosides

2001 ◽  
Vol 57 (2) ◽  
pp. 213-220 ◽  
Author(s):  
Artem Evdokimov ◽  
A. Joseph Gilboa ◽  
Thomas F. Koetzle ◽  
Wim T. Klooster ◽  
Arthur J. Schultz ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Crystal Structures ◽  
Critical Role ◽  
Chair Conformation ◽  
Geometrical Analysis ◽  
X Ray ◽  
Wide Range ◽  
First Time ◽  
Ring Conformations

Crystal structures of all five crystalline methyl D-pentofuranosides, methyl α-D-arabinofuranoside (1), methyl β-D-arabinofuranoside (2), methyl α-D-lyxofuranoside (3), methyl β-D-ribofuranoside (4) and methyl α-D-xylofuranoside (5) have been determined by means of cryogenic X-ray and neutron crystallography. The neutron diffraction experiments provide accurate, unbiased H-atom positions which are especially important because of the critical role of hydrogen bonding in these systems. This paper summarizes the geometrical and conformational parameters of the structures of all five crystalline methyl pentofuranosides, several of them reported here for the first time. The methyl pentofuranoside structures are compared with the structures of the five crystalline methyl hexopyranosides for which accurate X-ray and neutron structures have been determined. Unlike the methyl hexopyranosides, which crystallize exclusively in the C 1 chair conformation, the five crystalline methyl pentofuranosides represent a very wide range of ring conformations.

The Role of the SLP in Autism Spectrum Disorder Screening and Assessment

2008 ◽  
Vol 15 (2) ◽  
pp. 50-59 ◽  
Author(s):  
Amy Philofsky
Keyword(s):  
Language Development ◽  
Critical Role ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Children With Asd ◽  
Prevalence Estimates ◽  
Notable Increase ◽  
Screening Assessment ◽  
Critical Components

AbstractRecent prevalence estimates for autism have been alarming as a function of the notable increase. Speech-language pathologists play a critical role in screening, assessment and intervention for children with autism. This article reviews signs that may be indicative of autism at different stages of language development, and discusses the importance of several psychometric properties—sensitivity and specificity—in utilizing screening measures for children with autism. Critical components of assessment for children with autism are reviewed. This article concludes with examples of intervention targets for children with ASD at various levels of language development.

A critical role of iNOS-derived Nitric Oxide (NO) and progesterone in implantation

1998 ◽  
Vol 5 (1) ◽  
pp. 115A-115A
Author(s):  
K CHWALISZ ◽  
E WINTERHAGER ◽  
T THIENEL ◽  
R GARFIELD
Keyword(s):  
Nitric Oxide ◽  
Critical Role
Sign in / Sign up

Export Citation Format

Share Document