Substrate−Protein Interaction in Human Tryptophan Dioxygenase: The Critical Role of H76

Dipanwita Batabyal; Syun-Ru Yeh

doi:10.1021/ja807969a

Substrate−Protein Interaction in Human Tryptophan Dioxygenase: The Critical Role of H76

Journal of the American Chemical Society ◽

10.1021/ja807969a ◽

2009 ◽

Vol 131 (9) ◽

pp. 3260-3270 ◽

Cited By ~ 32

Author(s):

Dipanwita Batabyal ◽

Syun-Ru Yeh

Keyword(s):

Protein Interaction ◽

Critical Role ◽

Substrate Protein ◽

Tryptophan Dioxygenase

Download Full-text

The Critical Role of Substrate-Protein Hydrogen Bonding in the Control of Regioselective Hydroxylation in P450cin

Journal of Biological Chemistry ◽

10.1074/jbc.m709722200 ◽

2008 ◽

Vol 283 (16) ◽

pp. 10804-10812 ◽

Cited By ~ 29

Author(s):

Yergalem T. Meharenna ◽

Kate E. Slessor ◽

Sonia M. Cavaignac ◽

Thomas L. Poulos ◽

James J. De Voss

Keyword(s):

Hydrogen Bonding ◽

Critical Role ◽

Substrate Protein ◽

Regioselective Hydroxylation

Download Full-text

Substrate-Protein Interaction in Human Tryptophan dioxygenase

Biophysical Journal ◽

10.1016/j.bpj.2008.12.2249 ◽

2009 ◽

Vol 96 (3) ◽

pp. 438a ◽

Cited By ~ 1

Author(s):

Dipanwita Batabyal ◽

Syun-Ru Yeh

Keyword(s):

Protein Interaction ◽

Substrate Protein ◽

Tryptophan Dioxygenase

Download Full-text

Impact of Ubiquitination Signaling Pathway Modifications on Oral Carcinoma

Cancer Diagnosis & Prognosis ◽

10.21873/cdp.10069 ◽

2022 ◽

Vol 2 (1) ◽

pp. 1-6

Author(s):

EFTHIMIOS KYRODIMOS ◽

ARISTEIDIS CHRYSOVERGIS ◽

NICHOLAS MASTRONIKOLIS ◽

EVANGELOS TSIAMBAS ◽

LOUKAS MANAIOS ◽

...

Keyword(s):

Signaling Pathways ◽

Broad Spectrum ◽

Critical Role ◽

Ubiquitin Proteasome System ◽

Protein Targets ◽

Metabolism Regulation ◽

Substrate Protein ◽

Ubiquitin Proteasome ◽

Ubiquitin Conjugation

Among intra-cellular homeostasis mechanisms, ubiquitination plays a critical role in protein metabolism regulation by degrading proteins via activating a broad spectrum of ubiquitin chains. In fact, ubiquitination and sumoylation signaling pathways are characterized by increased complexity regarding the molecules and their interactions. The Ubiquitin-Proteasome System (Ub-PS) recognizes and targets a broad spectrum of protein substrates. Ubiquitin conjugation modifies each substrate protein determining its biochemical fate (degradation). A major functional activity of Ub-PS is autophagy mechanism regulation. Interestingly, Ub-PS promotesall stages of bulk autophagy (initiation, execution, and termination). Autophagy is a crucial catabolic process that provides protein degradation and for this reason the interaction with Ub-PS is crucial. Furthermore, ubiquitination controls and regulates specific types of protein targets. Ub-PS is also involved in oxidative cellular stress and DNA damage response. Additionally, the functional role of Ub-PS in ribosome machinery regulation seems to be crucial. Concerning carcinogenesis, Ub-PS is involved in malignant disease development and progression by negatively affecting the corresponding TGF-B-, MEEK/MAPK/ERK-JNK- dependent signaling pathways. In the current review article, we describe the role of Ub-PSbiochemicalmodifications and alterations in oral squamous cell carcinoma (OSCC).

Download Full-text

The Role of the SLP in Autism Spectrum Disorder Screening and Assessment

Perspectives on Language Learning and Education ◽

10.1044/lle15.2.50 ◽

2008 ◽

Vol 15 (2) ◽

pp. 50-59 ◽

Cited By ~ 1

Author(s):

Amy Philofsky

Keyword(s):

Language Development ◽

Critical Role ◽

Children With Autism ◽

Autism Spectrum ◽

Children With Asd ◽

Prevalence Estimates ◽

Notable Increase ◽

Screening Assessment ◽

Critical Components

AbstractRecent prevalence estimates for autism have been alarming as a function of the notable increase. Speech-language pathologists play a critical role in screening, assessment and intervention for children with autism. This article reviews signs that may be indicative of autism at different stages of language development, and discusses the importance of several psychometric properties—sensitivity and specificity—in utilizing screening measures for children with autism. Critical components of assessment for children with autism are reviewed. This article concludes with examples of intervention targets for children with ASD at various levels of language development.

Download Full-text