scholarly journals Relationship between DNA Methylation States and Transcription of Individual Isoforms Encoded by the Protocadherin-α Gene Cluster

2008 ◽  
Vol 283 (18) ◽  
pp. 12064-12075 ◽  
Author(s):  
Masahumi Kawaguchi ◽  
Tomoko Toyama ◽  
Ryosuke Kaneko ◽  
Teruyoshi Hirayama ◽  
Yoshimi Kawamura ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Gene Cluster

scholarly journals An Epigenetic Switch Involving Overlapping Fur and DNA Methylation Optimizes Expression of a Type VI Secretion Gene Cluster

PLoS Genetics ◽  
2011 ◽  
Vol 7 (7) ◽  
pp. e1002205 ◽  
Author(s):  
Yannick R. Brunet ◽  
Christophe S. Bernard ◽  
Marthe Gavioli ◽  
Roland Lloubès ◽  
Eric Cascales
Keyword(s):  
Dna Methylation ◽  
Gene Cluster ◽  
Epigenetic Switch ◽  
Type Vi Secretion

scholarly journals Gene‐orientation‐dependent DNA methylation patterns in the mouse prolactin ( Prl ) family gene cluster locus

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Koji Hayakawa ◽  
Naoko Hattori ◽  
Momo Nakanishi ◽  
Jun Ohgane ◽  
Satoshi Tanaka ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Gene Cluster ◽  
Gene Orientation ◽  
Family Gene ◽  
Methylation Patterns

scholarly journals DNA methylation of insulin-like growth factor 2 and H19 cluster in cord blood and prenatal air pollution exposure to fine particulate matter

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Congrong Wang ◽  
Michelle Plusquin ◽  
Akram Ghantous ◽  
Zdenko Herceg ◽  
Rossella Alfano ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Particulate Matter ◽  
Growth Factor ◽  
Cord Blood ◽  
Gene Cluster ◽  
Methylation Level ◽  
Fine Particulate Matter ◽  
Methylation Status ◽  
Insulin Like Growth Factor ◽  
Fine Particulate

Abstract Background The IGF2 (insulin-like growth factor 2) and H19 gene cluster plays an important role during pregnancy as it promotes both foetal and placental growth. We investigated the association between cord blood DNA methylation status of the IGF2/H19 gene cluster and maternal fine particulate matter exposure during fetal life. To the best of our knowledge, this is the first study investigating the association between prenatal PM2.5 exposure and newborn DNA methylation of the IGF2/H19. Methods Cord blood DNA methylation status of IGF2/H19 cluster was measured in 189 mother-newborn pairs from the ENVIRONAGE birth cohort (Flanders, Belgium). We assessed the sex-specific association between residential PM2.5 exposure during pregnancy and the methylation level of CpG loci mapping to the IGF2/H19 cluster, and identified prenatal vulnerability by investigating susceptible time windows of exposure. We also addressed the biological functionality of DNA methylation level in the gene cluster. Results Prenatal PM2.5 exposure was found to have genetic region-specific significant association with IGF2 and H19 during specific gestational weeks. The association was found to be sex-specific in both gene regions. Functionality of the DNA methylation was annotated by the association to fetal growth and cellular pathways. Conclusions The results of our study provided evidence that prenatal PM2.5 exposure is associated with DNA methylation in newborns’ IGF2/H19. The consequences within the context of fetal development of future phenotyping should be addressed.

Epigenetic Analysis of Beta-Globin Gene Cluster during Hematopoiesis.

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 1863-1863
Author(s):  
Supachai Ekwattanakit ◽  
Suchada Riolueang ◽  
Vip Viprakasit
Keyword(s):  
Dna Methylation ◽  
Gene Cluster ◽  
Methylation Level ◽  
Globin Gene ◽  
Clinical Severity ◽  
Globin Genes ◽  
Erythroid Cells ◽  
Global Methylation ◽  
Cpg Dinucleotides ◽  
Globin Gene Cluster

Abstract Hemoglobin (Hb) switching is described as temporal, tissue- and stage-specific patterns of globin gene expression; from embryonic to fetal and adult Hb in parallel to developmental stages of erythropoiesis. DNA methylation, one of the epigenetic mechanisms, was associated with inactivated chromatin domain and repressive transcription. To study the role of the DNA methylation on the beta (β)-globin genes, we analyzed CpG dinucleotides in 87 kb regions around β-globin gene cluster, including 5’upstream locus control regions (LCR; DNAse I Hypersensitive site (HS) 1–5), 3’HS1, the promoter regions of the G-and A-gamma (Gγ and Aγ), and β-globin genes, in several representative cells. These cells were primary adult erythroid cells culture (three different stages: early, intermediate, and late), fetal cord blood DNA, and neutrophil cell line (non-erythroid). Using bisulphite modification, followed by nested PCR and in vitro translation, the cleavage products were analysed by MALDI-TOF Mass Spectrometry to quantify the DNA methylation level. The results were consistent with bisulphite sequencing. We found that the promoters of Gγ and Aγ-globin genes were significantly hypomethylated in fetal cells (44% and 47% global methylation), when γ-globin genes were fully expressed, while they were heavily methylated in non-erythroid (86% and 95%). There was also a decreasing trend of the DNA methylation level at Gγ and Aγ-globin genes during adult erythroid differentiation from 80% and 82%, in early stage, to 67% and 66% in late stage (p=0.12 and 0.04). At β-globin promoter, the global methylation level changed from 90% in non-erythroid to 81%, 42%, and 26% in fetal, early and late adult erythroid cells, respectively. Moreover, we found the significant changes at 5’HS4, 3, and 1 as all erythroid cells were hypomethylated compare to non-erythroid. While at the insulators, 5’HS5 and 3’HS1, all tested CpG dinucleotides were heavily methylated in all cells. This is the first report that demonstrates the differences in DNA methylation at β-globin LCR between erythroid and non-erythroid cells. These epigenetic marks were associated with globin genes expression and might be useful to predict clinical severity in patients with β-thalassemia intermedia.

scholarly journals DNA methylation regulates long-range gene silencing of an X-linked homeobox gene cluster in a lineage-specific manner

2006 ◽  
Vol 20 (24) ◽  
pp. 3382-3394 ◽  
Author(s):  
M. Oda ◽  
A. Yamagiwa ◽  
S. Yamamoto ◽  
T. Nakayama ◽  
A. Tsumura ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Gene Silencing ◽  
Gene Cluster ◽  
Long Range ◽  
Homeobox Gene ◽  
Specific Manner

Relationship between DNA methylation and gene expression in the protocadherin gene cluster

2010 ◽  
Vol 68 ◽  
pp. e352
Author(s):  
Shunsuke Toyoda ◽  
Masahumi Kawaguchi ◽  
Tomoko Toyama ◽  
Masaki Okano ◽  
Masaaki Oda ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Gene Cluster

scholarly journals Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology

2018 ◽  
Vol 14 (12) ◽  
pp. 1580-1588 ◽  
Author(s):  
Rebecca G. Smith ◽  
Eilis Hannon ◽  
Philip L. De Jager ◽  
Lori Chibnik ◽  
Simon J. Lott ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Dna Methylation ◽  
Gene Cluster ◽  
Hoxa Gene

scholarly journals The Rhox Homeobox Gene Cluster Is Imprinted and Selectively Targeted for Regulation by Histone H1 and DNA Methylation

2011 ◽  
Vol 31 (6) ◽  
pp. 1275-1287 ◽  
Author(s):  
J. A. MacLean ◽  
A. Bettegowda ◽  
B. J. Kim ◽  
C.-H. Lou ◽  
S.-M. Yang ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Gene Cluster ◽  
Homeobox Gene ◽  
Histone H1

The regulation of DNA methylation pattern in the Pcdh-α gene cluster during development

2009 ◽  
Vol 65 ◽  
pp. S151
Author(s):  
Shunsuke Toyoda ◽  
Masahumi Kawaguchi ◽  
Tomoko Toyama ◽  
Masaki Okano ◽  
Masaaki Oda ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Gene Cluster ◽  
Methylation Pattern ◽  
Dna Methylation Pattern

scholarly journals Cocaine-related DNA methylation in caudate neurons alters 3D chromatin structure of the IRXA gene cluster

2020 ◽  
Author(s):  
Kathryn Vaillancourt ◽  
Jennie Yang ◽  
Gary G. Chen ◽  
Volodymyr Yerko ◽  
Jean-François Théroux ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Gene Cluster ◽  
Chromatin Structure ◽  
3D Chromatin Structure
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