scholarly journals Cisplatin Stabilizes a Multimeric Complex of the Human Ctr1 Copper Transporter

2004 ◽  
Vol 279 (45) ◽  
pp. 46393-46399 ◽  
Author(s):  
Yan Guo ◽  
Kathryn Smith ◽  
Michael J. Petris
Keyword(s):  
Copper Transporter ◽  
Multimeric Complex

scholarly journals Systemic deletion of Atp7b modifies the hepatocytes’ response to copper overload in the mouse models of Wilson disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Abigael Muchenditsi ◽  
C. Conover Talbot ◽  
Aline Gottlieb ◽  
Haojun Yang ◽  
Byunghak Kang ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Respiratory Chain ◽  
Wilson Disease ◽  
Mouse Strains ◽  
Chromosomal Replication ◽  
Copper Transporter ◽  
Cu Content ◽  
Common Response ◽  
The Common ◽  
Copper Overload

AbstractWilson disease (WD) is caused by inactivation of the copper transporter Atp7b and copper overload in tissues. Mice with Atp7b deleted either globally (systemic inactivation) or only in hepatocyte recapitulate various aspects of human disease. However, their phenotypes vary, and neither the common response to copper overload nor factors contributing to variability are well defined. Using metabolic, histologic, and proteome analyses in three Atp7b-deficient mouse strains, we show that global inactivation of Atp7b enhances and specifically modifies the hepatocyte response to Cu overload. The loss of Atp7b only in hepatocytes dysregulates lipid and nucleic acid metabolisms and increases the abundance of respiratory chain components and redox balancing enzymes. In global knockouts, independently of their background, the metabolism of lipid, nucleic acid, and amino acids is inhibited, respiratory chain components are down-regulated, inflammatory response and regulation of chromosomal replication are enhanced. Decrease in glucokinase and lathosterol oxidase and elevation of mucin-13 and S100A10 are observed in all Atp7b mutant strains and reflect the extent of liver injury. The magnitude of proteomic changes in Atp7b−/− animals inversely correlates with the metallothioneins levels rather than liver Cu content. These findings facilitate identification of WD-specific metabolic and proteomic changes for diagnostic and treatment.

scholarly journals Abnormalities in the copper transporter CTR1 in postmortem hippocampus in schizophrenia: A subregion and laminar analysis

2021 ◽  
Vol 228 ◽  
pp. 60-73
Author(s):  
Kirsten E. Schoonover ◽  
Charlene B. Farmer ◽  
Charity J. Morgan ◽  
Vidushi Sinha ◽  
Laura Odom ◽  
...  
Keyword(s):  
Copper Transporter

scholarly journals Copper Promotes Tumorigenesis by Activating the PDK1‐AKT Oncogenic Pathway in a Copper Transporter 1 Dependent Manner

2021 ◽  
pp. 2004303
Author(s):  
Jianping Guo ◽  
Ji Cheng ◽  
Nana Zheng ◽  
Xiaomei Zhang ◽  
Xiaoming Dai ◽  
...  
Keyword(s):  
Dependent Manner ◽  
Copper Transporter ◽  
Oncogenic Pathway ◽  
Copper Transporter 1

scholarly journals Relationship between Down-Regulation of Copper-Related Genes and Decreased Ferroportin Protein Level in the Duodenum of Iron-Deficient Piglets

Nutrients ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 104
Author(s):  
Aneta Jończy ◽  
Rafał Mazgaj ◽  
Rafał Radosław Starzyński ◽  
Piotr Poznański ◽  
Mateusz Szudzik ◽  
...  
Keyword(s):  
Iron Absorption ◽  
Underlying Mechanism ◽  
Metabolic Effects ◽  
Deficiency Anemia ◽  
Copper Transporter ◽  
Cellular Iron ◽  
Iron Deficient ◽  
Copper Distribution ◽  
Iron Deposits ◽  
Neonatal Iron Deficiency

In mammals, 2 × 1012 red blood cells (RBCs) are produced every day in the bone marrow to ensure a constant supply of iron to maintain effective erythropoiesis. Impaired iron absorption in the duodenum and inefficient iron reutilization from senescent RBCs by macrophages contribute to the development of anemia. Ferroportin (Fpn), the only known cellular iron exporter, as well as hephaestin (Heph) and ceruloplasmin, two copper-dependent ferroxidases involved in the above-mentioned processes, are key elements of the interaction between copper and iron metabolisms. Crosslinks between these metals have been known for many years, but metabolic effects of one on the other have not been elucidated to date. Neonatal iron deficiency anemia in piglets provides an interesting model for studying this interplay. In duodenal enterocytes of young anemic piglets, we identified iron deposits and demonstrated increased expression of ferritin with a concomitant decline in both Fpn and Heph expression. We postulated that the underlying mechanism involves changes in copper distribution within enterocytes as a result of decreased expression of the copper transporter—Atp7b. Obtained results strongly suggest that regulation of iron absorption within enterocytes is based on the interaction between proteins of copper and iron metabolisms and outcompetes systemic regulation.

scholarly journals Unexpected Role of the Copper Transporter ATP7A in PDGF-Induced Vascular Smooth Muscle Cell Migration

2010 ◽  
Vol 107 (6) ◽  
pp. 787-799 ◽  
Author(s):  
Takashi Ashino ◽  
Varadarajan Sudhahar ◽  
Norifumi Urao ◽  
Jin Oshikawa ◽  
Gin-Fu Chen ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Cell Migration ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Copper Transporter ◽  
Smooth Muscle Cell Migration

scholarly journals Role of the Copper Transporter, CTR1, in Platinum-Induced Ototoxicity

2010 ◽  
Vol 30 (28) ◽  
pp. 9500-9509 ◽  
Author(s):  
S. S. More ◽  
O. Akil ◽  
A. G. Ianculescu ◽  
E. G. Geier ◽  
L. R. Lustig ◽  
...  
Keyword(s):  
Copper Transporter
Sign in / Sign up

Export Citation Format

Share Document