scholarly journals Copper Promotes Tumorigenesis by Activating the PDK1‐AKT Oncogenic Pathway in a Copper Transporter 1 Dependent Manner

2021 ◽  
pp. 2004303
Author(s):  
Jianping Guo ◽  
Ji Cheng ◽  
Nana Zheng ◽  
Xiaomei Zhang ◽  
Xiaoming Dai ◽  
...  
Keyword(s):  
Dependent Manner ◽  
Copper Transporter ◽  
Oncogenic Pathway ◽  
Copper Transporter 1

scholarly journals Impact of Expression Levels of Platinum-uptake Transporters Copper Transporter 1 and Organic Cation Transporter 2 on Resistance to Anthracycline/Taxane-based Chemotherapy in Triple-negative Breast Cancer

2015 ◽  
Vol 9 ◽  
pp. BCBCR.S27534
Author(s):  
Risa Takeda ◽  
Ayano Naka ◽  
Naoki Ogane ◽  
Yoichi Kameda ◽  
Kae Kawachi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative ◽  
Organic Cation ◽  
Organic Cation Transporter ◽  
Platinum Drugs ◽  
Ki 67 ◽  
Copper Transporter ◽  
Organic Cation Transporter 2 ◽  
Uptake Transporters ◽  
Copper Transporter 1

Adding platinum drugs to anthracycline/taxane (ANC-Tax)-based neoadjuvant chemotherapy (NAC) improves pathological complete response (pCR) rates in triple-negative breast cancer (TNBC). Copper transporter 1 (CTR1) and organic cation transporter 2 (OCT2) critically affect the uptake and cytotoxicity of platinum drugs. We immunohistochemically determined CTR1 and OCT2 levels in pre-chemotherapy biopsies from 105 patients with HER2-negative breast cancer treated with ANC-Tax-based NAC. In the TNBC group, Ki-67high [pathological good response (pGR), P = 0.04] was associated with response, whereas CTR1high (non-pGR, P = 0.03), OCT2high (non-pGR, P = 0.01; non-pCR, P = 0.03), and combined CTR1high and/or OCT2high (non-pGR, P = 0.005; non-pCR, P = 0.003) were associated with non-response. In multivariate analysis, Ki-67high was an independent factor for pGR and CTR1 for non-pGR. Combined CTR1/OCT2 was a strong independent factor for non-pGR. However, no variables were associated with response in luminal BC. These results indicate that platinum uptake transporters are predominantly expressed in ANC-Tax-resistant TNBCs, which implies that advantage associated with adding platinum drugs may depend on high drug uptake.

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