scholarly journals Stimulation of Flap Endonuclease-1 by the Bloom's Syndrome Protein

2003 ◽  
Vol 279 (11) ◽  
pp. 9847-9856 ◽  
Author(s):  
Sudha Sharma ◽  
Joshua A. Sommers ◽  
Leonard Wu ◽  
Vilhelm A. Bohr ◽  
Ian D. Hickson ◽  
...  
Keyword(s):  
Bloom's Syndrome ◽  
Flap Endonuclease 1 ◽  
Bloom’S Syndrome ◽  
Syndrome Protein ◽  
Stimulation Of

scholarly journals Bloom's syndrome protein response to ultraviolet-C radiation and hydroxyurea-mediated DNA synthesis inhibition

Oncogene ◽  
2002 ◽  
Vol 21 (13) ◽  
pp. 2079-2088 ◽  
Author(s):  
Mouna Ababou ◽  
Virginie Dumaire ◽  
Yann Lécluse ◽  
Mounira Amor-Guéret
Keyword(s):  
Dna Synthesis ◽  
Bloom's Syndrome ◽  
Synthesis Inhibition ◽  
Bloom’S Syndrome ◽  
Ultraviolet C ◽  
Protein Response ◽  
Syndrome Protein ◽  
Dna Synthesis Inhibition

Genomic instability and cancer: lessons from analysis of Bloom's syndrome

2009 ◽  
Vol 37 (3) ◽  
pp. 553-559 ◽  
Author(s):  
Miranda Payne ◽  
Ian D. Hickson
Keyword(s):  
Genomic Instability ◽  
Mitotic Chromosome ◽  
Genetic Defect ◽  
Autosomal Recessive Disorder ◽  
Recq Helicase ◽  
Bloom's Syndrome ◽  
Binding Partners ◽  
Bloom’S Syndrome ◽  
Syndrome Protein ◽  
Blm Gene

Bloom's syndrome (BS) is a rare autosomal recessive disorder characterized by genomic instability and cancer predisposition. The underlying genetic defect is mutation of the BLM gene, producing deficiency in the RecQ helicase BLM (Bloom's syndrome protein). The present article begins by introducing BLM and its binding partners before reviewing its known biochemical activities and its potential roles both as a pro-recombinase and as a suppressor of homologous recombination. Finally, the evidence for an emerging role in mitotic chromosome segregation is examined.

Bloom’s syndrome protein unfolding G-quadruplexes in two pathways

2017 ◽  
Vol 26 (8) ◽  
pp. 088701
Author(s):  
Zhen-Ye Zhao ◽  
Chun-Hua Xu ◽  
Jing Shi ◽  
Jing-Hua Li ◽  
Jian-Bing Ma ◽  
...  
Keyword(s):  
Protein Unfolding ◽  
Bloom's Syndrome ◽  
Bloom’S Syndrome ◽  
Syndrome Protein

scholarly journals BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity

2005 ◽  
Vol 24 (7) ◽  
pp. 1465-1476 ◽  
Author(s):  
Jinhu Yin ◽  
Alexandra Sobeck ◽  
Chang Xu ◽  
Amom Ruhikanta Meetei ◽  
Maureen Hoatlin ◽  
...  
Keyword(s):  
Protein Complexes ◽  
Genome Integrity ◽  
Bloom's Syndrome ◽  
Essential Component ◽  
Bloom’S Syndrome ◽  
Syndrome Protein

scholarly journals Replication Protein A Physically Interacts with the Bloom's Syndrome Protein and Stimulates Its Helicase Activity

2000 ◽  
Vol 275 (31) ◽  
pp. 23500-23508 ◽  
Author(s):  
Robert M. Brosh ◽  
Ji-Liang Li ◽  
Mark K. Kenny ◽  
Julia K. Karow ◽  
Marcus P. Cooper ◽  
...  
Keyword(s):  
Protein A ◽  
Replication Protein A ◽  
Replication Protein ◽  
Helicase Activity ◽  
Bloom's Syndrome ◽  
Bloom’S Syndrome ◽  
Syndrome Protein

scholarly journals The Bloom's Syndrome Protein (BLM) Interacts with MLH1 but Is Not Required for DNA Mismatch Repair

2001 ◽  
Vol 276 (32) ◽  
pp. 30031-30035 ◽  
Author(s):  
Gregory Langland ◽  
Jennifer Kordich ◽  
Jenette Creaney ◽  
Kathleen Heppner Goss ◽  
Kate Lillard-Wetherell ◽  
...  
Keyword(s):  
Mismatch Repair ◽  
Dna Mismatch Repair ◽  
Bloom's Syndrome ◽  
Dna Mismatch ◽  
Bloom’S Syndrome ◽  
Syndrome Protein
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