Functional Importance of Polar and Charged Amino Acid Residues in Transmembrane Helix 14 of Multidrug Resistance Protein 1 (MRP1/ABCC1)

Da-Wei Zhang; Hong-Mei Gu; Donna Situ; Anass Haimeur; Susan P. C. Cole; Roger G. Deeley

doi:10.1074/jbc.m308403200

Functional Importance of Polar and Charged Amino Acid Residues in Transmembrane Helix 14 of Multidrug Resistance Protein 1 (MRP1/ABCC1)

Journal of Biological Chemistry ◽

10.1074/jbc.m308403200 ◽

2003 ◽

Vol 278 (46) ◽

pp. 46052-46063 ◽

Cited By ~ 40

Author(s):

Da-Wei Zhang ◽

Hong-Mei Gu ◽

Donna Situ ◽

Anass Haimeur ◽

Susan P. C. Cole ◽

...

Keyword(s):

Multidrug Resistance ◽

Amino Acid ◽

Transmembrane Helix ◽

Multidrug Resistance Protein ◽

Amino Acid Residues ◽

Functional Importance ◽

Multidrug Resistance Protein 1 ◽

Resistance Protein

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MUTATIONAL ANALYSIS OF POLAR AMINO ACID RESIDUES WITHIN PREDICTED TRANSMEMBRANE HELICES 10 AND 16 OF MULTIDRUG RESISTANCE PROTEIN 1 (ABCC1): EFFECT ON SUBSTRATE SPECIFICITY

Drug Metabolism and Disposition ◽

10.1124/dmd.105.007740 ◽

2006 ◽

Vol 34 (4) ◽

pp. 539-546 ◽

Cited By ~ 17

Author(s):

Da-Wei Zhang ◽

Kenichi Nunoya ◽

Monika Vasa ◽

Hong-Mei Gu ◽

Susan P. C. Cole ◽

...

Keyword(s):

Multidrug Resistance ◽

Amino Acid ◽

Substrate Specificity ◽

Mutational Analysis ◽

Multidrug Resistance Protein ◽

Amino Acid Residues ◽

Transmembrane Helices ◽

Polar Amino Acid ◽

Multidrug Resistance Protein 1 ◽

Resistance Protein

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The amino acid residues of transmembrane helix 5 of multidrug resistance protein CaCdr1p of Candida albicans are involved in substrate specificity and drug transport

Biochimica et Biophysica Acta (BBA) - Biomembranes ◽

10.1016/j.bbamem.2009.04.009 ◽

2009 ◽

Vol 1788 (9) ◽

pp. 1752-1761 ◽

Cited By ~ 17

Author(s):

Nidhi Puri ◽

Manisha Gaur ◽

Monika Sharma ◽

Suneet Shukla ◽

Suresh V. Ambudkar ◽

...

Keyword(s):

Candida Albicans ◽

Multidrug Resistance ◽

Amino Acid ◽

Substrate Specificity ◽

Drug Transport ◽

Transmembrane Helix ◽

Multidrug Resistance Protein ◽

Amino Acid Residues ◽

Resistance Protein

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Mutational analysis of polar amino acid residues within predicted transmembrane helices of Multidrug Resistance Protein 1 (ABCC1): Effect on substrate specificity

The FASEB Journal ◽

10.1096/fasebj.21.5.a196-a ◽

2007 ◽

Vol 21 (5) ◽

Author(s):

Da‐Wei Zhang ◽

Susan P.C. Cole ◽

Roger G. Deeley

Keyword(s):

Multidrug Resistance ◽

Amino Acid ◽

Substrate Specificity ◽

Mutational Analysis ◽

Multidrug Resistance Protein ◽

Amino Acid Residues ◽

Transmembrane Helices ◽

Polar Amino Acid ◽

Multidrug Resistance Protein 1 ◽

Resistance Protein

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Characterization of the Role of Polar Amino Acid Residues within Predicted Transmembrane Helix 17 in Determining the Substrate Specificity of Multidrug Resistance Protein 3†

Biochemistry ◽

10.1021/bi034462b ◽

2003 ◽

Vol 42 (33) ◽

pp. 9989-10000 ◽

Cited By ~ 30

Author(s):

Da-Wei Zhang ◽

Hong-Mei Gu ◽

Monika Vasa ◽

Mario Muredda ◽

Susan P. C. Cole ◽

...

Keyword(s):

Multidrug Resistance ◽

Amino Acid ◽

Transmembrane Helix ◽

Multidrug Resistance Protein ◽

Amino Acid Residues ◽

Polar Amino Acid ◽

Multidrug Resistance Protein 3 ◽

Resistance Protein

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Identification of an Amino Acid Residue in Multidrug Resistance Protein 1 Critical for Conferring Resistance to Anthracyclines

Journal of Biological Chemistry ◽

10.1074/jbc.m010008200 ◽

2001 ◽

Vol 276 (16) ◽

pp. 13231-13239 ◽

Cited By ~ 70

Author(s):

Da-Wei Zhang ◽

Susan P. C. Cole ◽

Roger G. Deeley

Keyword(s):

Multidrug Resistance ◽

Amino Acid ◽

Amino Acid Residue ◽

Multidrug Resistance Protein ◽

Multidrug Resistance Protein 1 ◽

Resistance Protein

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Molecular Modeling Correctly Predicts the Functional Importance of Phe594in Transmembrane Helix 11 of the Multidrug Resistance Protein, MRP1 (ABCC1)

Journal of Biological Chemistry ◽

10.1074/jbc.m310711200 ◽

2003 ◽

Vol 279 (1) ◽

pp. 463-468 ◽

Cited By ~ 54

Author(s):

Jeff D. Campbell ◽

Koji Koike ◽

Christophe Moreau ◽

Michael S. P. Sansom ◽

Roger G. Deeley ◽

...

Keyword(s):

Multidrug Resistance ◽

Molecular Modeling ◽

Transmembrane Helix ◽

Multidrug Resistance Protein ◽

Functional Importance ◽

Resistance Protein

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An Outward-Facing Aromatic Amino Acid Is Crucial for Signaling between the Membrane-Spanning and Nucleotide-Binding Domains of Multidrug Resistance Protein 1 (MRP1; ABCC1)

Molecular Pharmacology ◽

10.1124/mol.118.112615 ◽

2018 ◽

Vol 94 (3) ◽

pp. 1069-1078 ◽

Cited By ~ 6

Author(s):

Kevin E. Weigl ◽

Gwenaëlle Conseil ◽

Alice J. Rothnie ◽

May Arama ◽

Yossi Tsfadia ◽

...

Keyword(s):

Multidrug Resistance ◽

Amino Acid ◽

Aromatic Amino Acid ◽

Nucleotide Binding ◽

Multidrug Resistance Protein ◽

Multidrug Resistance Protein 1 ◽

Binding Domains ◽

Resistance Protein ◽

Membrane Spanning

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Transmembrane Helix 11 of Multidrug Resistance Protein 1 (MRP1/ABCC1): Identification of Polar Amino Acids Important for Substrate Specificity and Binding of ATP at Nucleotide Binding Domain 1†

Biochemistry ◽

10.1021/bi0495230 ◽

2004 ◽

Vol 43 (29) ◽

pp. 9413-9425 ◽

Cited By ~ 23

Author(s):

Da-Wei Zhang ◽

Kenichi Nunoya ◽

Monika Vasa ◽

Hong-Mei Gu ◽

Ashley Theis ◽

...

Keyword(s):

Amino Acids ◽

Multidrug Resistance ◽

Substrate Specificity ◽

Transmembrane Helix ◽

Nucleotide Binding ◽

Multidrug Resistance Protein ◽

Nucleotide Binding Domain ◽

Multidrug Resistance Protein 1 ◽

Resistance Protein ◽

Nucleotide Binding Domain 1

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Charged Amino Acids in the Sixth Transmembrane Helix of Multidrug Resistance Protein 1 (MRP1/ABCC1) Are Critical Determinants of Transport Activity

Journal of Biological Chemistry ◽

10.1074/jbc.m206228200 ◽

2002 ◽

Vol 277 (44) ◽

pp. 41326-41333 ◽

Cited By ~ 48

Author(s):

Anass Haimeur ◽

Roger G. Deeley ◽

Susan P. C. Cole

Keyword(s):

Amino Acids ◽

Multidrug Resistance ◽

Transmembrane Helix ◽

Multidrug Resistance Protein ◽

Transport Activity ◽

Multidrug Resistance Protein 1 ◽

Charged Amino Acids ◽

Resistance Protein

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Molecular modeling correctly predicts the functional importance of Phe594 in transmembrane helix 11 of the multidrug resistance protein, MRP1 (ABCC1). Vol. 279 (2004) 463-468

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)81405-3 ◽

2004 ◽

Vol 279 (8) ◽

pp. 7360

Author(s):

Jeff D. Campbell ◽

Koji Koike ◽

Christophe Moreau ◽

Mark S.P. Sansom ◽

Roger G. Deeley ◽

...

Keyword(s):

Multidrug Resistance ◽

Molecular Modeling ◽

Transmembrane Helix ◽

Multidrug Resistance Protein ◽

Functional Importance ◽

Resistance Protein

Download Full-text