Transmembrane Helix 11 of Multidrug Resistance Protein 1 (MRP1/ABCC1):  Identification of Polar Amino Acids Important for Substrate Specificity and Binding of ATP at Nucleotide Binding Domain 1†

Da-Wei Zhang; Kenichi Nunoya; Monika Vasa; Hong-Mei Gu; Ashley Theis; Susan P. C. Cole; Roger G. Deeley

doi:10.1021/bi0495230

Transmembrane Helix 11 of Multidrug Resistance Protein 1 (MRP1/ABCC1): Identification of Polar Amino Acids Important for Substrate Specificity and Binding of ATP at Nucleotide Binding Domain 1†

Biochemistry ◽

10.1021/bi0495230 ◽

2004 ◽

Vol 43 (29) ◽

pp. 9413-9425 ◽

Cited By ~ 23

Author(s):

Da-Wei Zhang ◽

Kenichi Nunoya ◽

Monika Vasa ◽

Hong-Mei Gu ◽

Ashley Theis ◽

...

Keyword(s):

Amino Acids ◽

Multidrug Resistance ◽

Substrate Specificity ◽

Transmembrane Helix ◽

Nucleotide Binding ◽

Multidrug Resistance Protein ◽

Nucleotide Binding Domain ◽

Multidrug Resistance Protein 1 ◽

Resistance Protein ◽

Nucleotide Binding Domain 1

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Structure of the Human Multidrug Resistance Protein 1 Nucleotide Binding Domain 1 bound to Mg2+/ATP Reveals a Non-productive Catalytic Site

Journal of Molecular Biology ◽

10.1016/j.jmb.2006.04.005 ◽

2006 ◽

Vol 359 (4) ◽

pp. 940-949 ◽

Cited By ~ 54

Author(s):

Odile Ramaen ◽

Nicolas Leulliot ◽

Christina Sizun ◽

Nathalie Ulryck ◽

Olivier Pamlard ◽

...

Keyword(s):

Multidrug Resistance ◽

Nucleotide Binding ◽

Catalytic Site ◽

Binding Domain ◽

Multidrug Resistance Protein ◽

Nucleotide Binding Domain ◽

Multidrug Resistance Protein 1 ◽

Resistance Protein ◽

Nucleotide Binding Domain 1

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Charged Amino Acids in the Sixth Transmembrane Helix of Multidrug Resistance Protein 1 (MRP1/ABCC1) Are Critical Determinants of Transport Activity

Journal of Biological Chemistry ◽

10.1074/jbc.m206228200 ◽

2002 ◽

Vol 277 (44) ◽

pp. 41326-41333 ◽

Cited By ~ 48

Author(s):

Anass Haimeur ◽

Roger G. Deeley ◽

Susan P. C. Cole

Keyword(s):

Amino Acids ◽

Multidrug Resistance ◽

Transmembrane Helix ◽

Multidrug Resistance Protein ◽

Transport Activity ◽

Multidrug Resistance Protein 1 ◽

Charged Amino Acids ◽

Resistance Protein

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Magnesium dependent complexation of tri-anionic calix[4]arene detergents by the nucleotide binding domain 1 (NBD1) of multidrug resistance protein MRP1

New Journal of Chemistry ◽

10.1039/c0nj00323a ◽

2010 ◽

Vol 34 (9) ◽

pp. 1812 ◽

Cited By ~ 3

Author(s):

Laurent F. A. Nault ◽

Celine Girardot ◽

Antoine Leydier ◽

Anthony W. Coleman ◽

Thomas Perrotton ◽

...

Keyword(s):

Multidrug Resistance ◽

Nucleotide Binding ◽

Binding Domain ◽

Multidrug Resistance Protein ◽

Nucleotide Binding Domain ◽

Resistance Protein ◽

Nucleotide Binding Domain 1

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Identification of Proline Residues in the Core Cytoplasmic and Transmembrane Regions of Multidrug Resistance Protein 1 (MRP1/ABCC1) Important for Transport Function, Substrate Specificity, and Nucleotide Interactions

Journal of Biological Chemistry ◽

10.1074/jbc.m311435200 ◽

2004 ◽

Vol 279 (13) ◽

pp. 12325-12336 ◽

Cited By ~ 58

Author(s):

Koji Koike ◽

Gwenaëlle Conseil ◽

Elaine M. Leslie ◽

Roger G. Deeley ◽

Susan P. C. Cole

Keyword(s):

Multidrug Resistance ◽

Substrate Specificity ◽

Multidrug Resistance Protein ◽

Transport Function ◽

Multidrug Resistance Protein 1 ◽

The Core ◽

Nucleotide Interactions ◽

Resistance Protein ◽

Transmembrane Regions

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Functional Interactions Between Nucleotide Binding Domains and Leukotriene C4 Binding Sites of Multidrug Resistance Protein 1 (ABCC1)

Molecular Pharmacology ◽

10.1124/mol.104.007708 ◽

2005 ◽

Vol 67 (6) ◽

pp. 1944-1953 ◽

Cited By ~ 20

Author(s):

Lea Payen ◽

Mian Gao ◽

Christopher Westlake ◽

Ashley Theis ◽

Susan P. C. Cole ◽

...

Keyword(s):

Multidrug Resistance ◽

Binding Sites ◽

Nucleotide Binding ◽

Multidrug Resistance Protein ◽

Leukotriene C4 ◽

Multidrug Resistance Protein 1 ◽

Functional Interactions ◽

Binding Domains ◽

Resistance Protein

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An Outward-Facing Aromatic Amino Acid Is Crucial for Signaling between the Membrane-Spanning and Nucleotide-Binding Domains of Multidrug Resistance Protein 1 (MRP1; ABCC1)

Molecular Pharmacology ◽

10.1124/mol.118.112615 ◽

2018 ◽

Vol 94 (3) ◽

pp. 1069-1078 ◽

Cited By ~ 6

Author(s):

Kevin E. Weigl ◽

Gwenaëlle Conseil ◽

Alice J. Rothnie ◽

May Arama ◽

Yossi Tsfadia ◽

...

Keyword(s):

Multidrug Resistance ◽

Amino Acid ◽

Aromatic Amino Acid ◽

Nucleotide Binding ◽

Multidrug Resistance Protein ◽

Multidrug Resistance Protein 1 ◽

Binding Domains ◽

Resistance Protein ◽

Membrane Spanning

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Mutations of Charged Amino Acids in or near the Transmembrane Helices of the Second Membrane Spanning Domain Differentially Affect the Substrate Specificity and Transport Activity of the Multidrug Resistance Protein MRP1 (ABCC1)

Molecular Pharmacology ◽

10.1124/mol.65.6.1375 ◽

2004 ◽

Vol 65 (6) ◽

pp. 1375-1385 ◽

Cited By ~ 58

Author(s):

Anass Haimeur ◽

Gwenaëlle Conseil ◽

Roger G. Deeley ◽

Susan P.C. Cole

Keyword(s):

Amino Acids ◽

Multidrug Resistance ◽

Substrate Specificity ◽

Multidrug Resistance Protein ◽

Transmembrane Helices ◽

Transport Activity ◽

Charged Amino Acids ◽

Resistance Protein ◽

Membrane Spanning

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Comparison of the Functional Characteristics of the Nucleotide Binding Domains of Multidrug Resistance Protein 1

Journal of Biological Chemistry ◽

10.1074/jbc.275.17.13098 ◽

2000 ◽

Vol 275 (17) ◽

pp. 13098-13108 ◽

Cited By ~ 131

Author(s):

Mian Gao ◽

Heng-Ran Cui ◽

Douglas W. Loe ◽

Caroline E. Grant ◽

Kurt C. Almquist ◽

...

Keyword(s):

Multidrug Resistance ◽

Nucleotide Binding ◽

Multidrug Resistance Protein ◽

Functional Characteristics ◽

Multidrug Resistance Protein 1 ◽

Binding Domains ◽

Resistance Protein

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Determinants of the Substrate Specificity of Multidrug Resistance Protein 1

Journal of Biological Chemistry ◽

10.1074/jbc.m201311200 ◽

2002 ◽

Vol 277 (23) ◽

pp. 20934-20941 ◽

Cited By ~ 34

Author(s):

Da-Wei Zhang ◽

Susan P. C. Cole ◽

Roger G. Deeley

Keyword(s):

Multidrug Resistance ◽

Substrate Specificity ◽

Multidrug Resistance Protein ◽

Multidrug Resistance Protein 1 ◽

Resistance Protein

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MUTATIONAL ANALYSIS OF POLAR AMINO ACID RESIDUES WITHIN PREDICTED TRANSMEMBRANE HELICES 10 AND 16 OF MULTIDRUG RESISTANCE PROTEIN 1 (ABCC1): EFFECT ON SUBSTRATE SPECIFICITY

Drug Metabolism and Disposition ◽

10.1124/dmd.105.007740 ◽

2006 ◽

Vol 34 (4) ◽

pp. 539-546 ◽

Cited By ~ 17

Author(s):

Da-Wei Zhang ◽

Kenichi Nunoya ◽

Monika Vasa ◽

Hong-Mei Gu ◽

Susan P. C. Cole ◽

...

Keyword(s):

Multidrug Resistance ◽

Amino Acid ◽

Substrate Specificity ◽

Mutational Analysis ◽

Multidrug Resistance Protein ◽

Amino Acid Residues ◽

Transmembrane Helices ◽

Polar Amino Acid ◽

Multidrug Resistance Protein 1 ◽

Resistance Protein

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