scholarly journals Translation Inhibitors Sensitize Prostate Cancer Cells to Apoptosis Induced by Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) by Activating c-Jun N-terminal Kinase

2003 ◽  
Vol 278 (23) ◽  
pp. 20593-20602 ◽  
Author(s):  
Nand K. Sah ◽  
Anupama Munshi ◽  
John F. Kurland ◽  
Timothy J. McDonnell ◽  
Bing Su ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Necrosis Factor ◽  
Cancer Cells ◽  
Tumor Necrosis ◽  
Prostate Cancer Cells ◽  
Necrosis Factor

Interleukin-6, Tumor Necrosis Factor-α Expression Levels in Prostate Cancer Tissues and Their Effects on Epithelial Interstitial Transformation, Migration and Invasion in Prostate Cancer Cells

2020 ◽  
Vol 10 (12) ◽  
pp. 1773-1779
Author(s):  
Desheng Li ◽  
Shanbin Zhang ◽  
Minfang Zuo ◽  
Xinming Hu ◽  
Shuming He
Keyword(s):  
Prostate Cancer ◽  
Tumor Necrosis Factor ◽  
Cancer Cells ◽  
Interleukin 6 ◽  
Tumor Necrosis ◽  
Epithelial Mesenchymal Transition ◽  
Migration And Invasion ◽  
Prostate Cancer Cells ◽  
Mesenchymal Transition ◽  
Necrosis Factor

Background: To investigate the expression of Interleukin-6, Interleukin-6 in prostate cancer tissues and its effect on migration and evasiveness of cancer cells. Material and Methods: The releasing of Interleukin-6, Tumor necrosis factor-α in prostate cancer cells was detected by ELISA method. For prostate cancer cells after knockout, additional Interleukin-6 or Tumor necrosis factor-α induction was given in vitro. After 12 h of culture, the effects of Interleukin-6, Tumor necrosis factor-α on the migration and evasiveness of prostate cancer cells were observed by Western blot method and matrices invasion experiment. Results: The expression of epithelial mesenchymal transition-related proteins, the migration and invasion ability of prostate cancer cells in each gene knockout group were significantly reduced. After induction of inflammatory factors (Interleukin-6 or Tumor necrosis factor-α) in the gene knockout group for 12 h, the expression levels of epithelial mesenchymal transition-related proteins, the migration and aggressiveness of prostate cancer were significantly higher than those after knockout. Conclusion: Interleukin-6 and Tumor necrosis factor-α can induce epithelial mesenchymal transition in LNCaP and PC3 cells, promote cell invasion and metastasis, and provide a new direction for future research.

scholarly journals Analysis of tumor necrosis factor α-induced and nuclear factor κB-silenced LNCaP prostate cancer cells by RT-qPCR

2014 ◽  
Vol 8 (6) ◽  
pp. 1695-1700 ◽  
Author(s):  
CEREN GONEN-KORKMAZ ◽  
GULNUR SEVIN ◽  
GOKSEL GOKCE ◽  
MEHMET ZUHURI ARUN ◽  
GOKCE YILDIRIM ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Necrosis Factor ◽  
Cancer Cells ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Prostate Cancer Cells ◽  
Factor Α ◽  
Necrosis Factor
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