scholarly journals HIV-1 Tat Protein-mediated Transactivation of the HIV-1 Long Terminal Repeat Promoter Is Potentiated by a Novel Nuclear Tat-interacting Protein of110 kDa, Tip110

2002 ◽  
Vol 277 (26) ◽  
pp. 23854-23863 ◽  
Author(s):  
Ying Liu ◽  
Jinliang Li ◽  
Byung Oh Kim ◽  
Betty S. Pace ◽  
Johnny J. He
PLoS ONE ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. e0125563 ◽  
Author(s):  
Fu-Chun Yang ◽  
Wen-Dong Kuang ◽  
Chuan Li ◽  
Wei-Wei Sun ◽  
Di Qu ◽  
...  

2015 ◽  
Vol 58 (24) ◽  
pp. 9639-9652 ◽  
Author(s):  
Rosalba Perrone ◽  
Filippo Doria ◽  
Elena Butovskaya ◽  
Ilaria Frasson ◽  
Silvia Botti ◽  
...  

2013 ◽  
Vol 56 (16) ◽  
pp. 6521-6530 ◽  
Author(s):  
Rosalba Perrone ◽  
Matteo Nadai ◽  
Ilaria Frasson ◽  
Jerrod A. Poe ◽  
Elena Butovskaya ◽  
...  

1997 ◽  
Vol 322 (1) ◽  
pp. 155-158 ◽  
Author(s):  
Yu-Zhen LIU ◽  
David S. LATCHMAN

Although the HIV-1 long terminal repeat (LTR) contains four potential binding sites for the octamer-binding protein, Oct-1, which is known to interact with the HIV-1 Tat protein, the effect of the Oct-1 factor on HIV LTR-driven gene expression has not previously been reported. We show here that both Oct-1, and to a lesser extent the related Oct-2 protein, can repress both the basal activity of the HIV-1 LTR and its transactivation by Tat. These effects are still observed with an HIV LTR construct containing only a single octamer-binding site located between the TATA box and the transcriptional start site. The stronger inhibitory effect of Oct-1 on both these promoters is dependent upon its C-terminal region which cannot be effectively replaced by the equivalent region of Oct-2. These effects are discussed in terms of the regulation of HIV LTR activity in different cell types and in response to T-cell activation.


2012 ◽  
Vol 287 (20) ◽  
pp. 16930-16946 ◽  
Author(s):  
Khalid Hussain Bhat ◽  
Chinta Krishna Chaitanya ◽  
Nazia Parveen ◽  
Raja Varman ◽  
Sudip Ghosh ◽  
...  

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