scholarly journals A Dynamic G-Quadruplex Region Regulates the HIV-1 Long Terminal Repeat Promoter

2013 ◽  
Vol 56 (16) ◽  
pp. 6521-6530 ◽  
Author(s):  
Rosalba Perrone ◽  
Matteo Nadai ◽  
Ilaria Frasson ◽  
Jerrod A. Poe ◽  
Elena Butovskaya ◽  
...  
Keyword(s):  
Long Terminal Repeat ◽  
Terminal Repeat ◽  
Long Terminal Repeat Promoter ◽  
G Quadruplex ◽  
Hiv 1

scholarly journals Synthesis, Binding and Antiviral Properties of Potent Core-Extended Naphthalene Diimides Targeting the HIV-1 Long Terminal Repeat Promoter G-Quadruplexes

2015 ◽  
Vol 58 (24) ◽  
pp. 9639-9652 ◽  
Author(s):  
Rosalba Perrone ◽  
Filippo Doria ◽  
Elena Butovskaya ◽  
Ilaria Frasson ◽  
Silvia Botti ◽  
...  
Keyword(s):  
Long Terminal Repeat ◽  
Terminal Repeat ◽  
Long Terminal Repeat Promoter ◽  
Naphthalene Diimides ◽  
Hiv 1

scholarly journals Structure and possible function of a G-quadruplex in the long terminal repeat of the proviral HIV-1 genome

2016 ◽  
Vol 44 (13) ◽  
pp. 6442-6451 ◽  
Author(s):  
Beatrice De Nicola ◽  
Christopher J. Lech ◽  
Brahim Heddi ◽  
Sagar Regmi ◽  
Ilaria Frasson ◽  
...  
Keyword(s):  
Long Terminal Repeat ◽  
Terminal Repeat ◽  
Competent Cell ◽  
Cell Infection ◽  
Transcription Analysis ◽  
Single Nucleotide ◽  
Biologically Relevant ◽  
G Quadruplex ◽  
Ltr Promoter ◽  
Hiv 1

Abstract The long terminal repeat (LTR) of the proviral human immunodeficiency virus (HIV)-1 genome is integral to virus transcription and host cell infection. The guanine-rich U3 region within the LTR promoter, previously shown to form G-quadruplex structures, represents an attractive target to inhibit HIV transcription and replication. In this work, we report the structure of a biologically relevant G-quadruplex within the LTR promoter region of HIV-1. The guanine-rich sequence designated LTR-IV forms a well-defined structure in physiological cationic solution. The nuclear magnetic resonance (NMR) structure of this sequence reveals a parallel-stranded G-quadruplex containing a single-nucleotide thymine bulge, which participates in a conserved stacking interaction with a neighboring single-nucleotide adenine loop. Transcription analysis in a HIV-1 replication competent cell indicates that the LTR-IV region may act as a modulator of G-quadruplex formation in the LTR promoter. Consequently, the LTR-IV G-quadruplex structure presented within this work could represent a valuable target for the design of HIV therapeutics.

scholarly journals Proline-Proline-Glutamic Acid (PPE) Protein Rv1168c ofMycobacterium tuberculosisAugments Transcription from HIV-1 Long Terminal Repeat Promoter

2012 ◽  
Vol 287 (20) ◽  
pp. 16930-16946 ◽  
Author(s):  
Khalid Hussain Bhat ◽  
Chinta Krishna Chaitanya ◽  
Nazia Parveen ◽  
Raja Varman ◽  
Sudip Ghosh ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Long Terminal Repeat ◽  
Terminal Repeat ◽  
Long Terminal Repeat Promoter ◽  
Hiv 1
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