Key Structural Determinants in the Agonist Binding Loops of Human β2 and β4 Nicotinic Acetylcholine Receptor Subunits Contribute to α3β4 Subtype Selectivity of α-Conotoxins

Hartmut Cuny; Shiva N. Kompella; Han-Shen Tae; Rilei Yu; David J. Adams

doi:10.1074/jbc.m116.730804

Key Structural Determinants in the Agonist Binding Loops of Human β2 and β4 Nicotinic Acetylcholine Receptor Subunits Contribute to α3β4 Subtype Selectivity of α-Conotoxins

Journal of Biological Chemistry ◽

10.1074/jbc.m116.730804 ◽

2016 ◽

Vol 291 (45) ◽

pp. 23779-23792 ◽

Cited By ~ 11

Author(s):

Hartmut Cuny ◽

Shiva N. Kompella ◽

Han-Shen Tae ◽

Rilei Yu ◽

David J. Adams

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Agonist Binding ◽

Structural Determinants ◽

Nicotinic Acetylcholine ◽

Subtype Selectivity

Download Full-text

Structure of the agonist-binding site of the nicotinic acetylcholine receptor. [3H]acetylcholine mustard identifies residues in the cation-binding subsite.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)54504-x ◽

1991 ◽

Vol 266 (34) ◽

pp. 23354-23364

Author(s):

J.B. Cohen ◽

S.D. Sharp ◽

W.S. Liu

Keyword(s):

Binding Site ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Cation Binding ◽

Agonist Binding ◽

Nicotinic Acetylcholine

Download Full-text

Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal α7 nicotinic acetylcholine receptor

The EMBO Journal ◽

10.1038/emboj.2009.227 ◽

2009 ◽

Vol 28 (19) ◽

pp. 3040-3051 ◽

Cited By ~ 119

Author(s):

Ryan E Hibbs ◽

Gerlind Sulzenbacher ◽

Jianxin Shi ◽

Todd T Talley ◽

Sandrine Conrod ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Binding Protein ◽

Structural Determinants ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Acetylcholine Binding Protein ◽

Partial Agonists

Download Full-text

In vivo relationship between thalamic nicotinic acetylcholine receptor occupancy rates and antiallodynic effects in a rat model of neuropathic pain: Persistent agonist binding inhibits the expression of antiallodynic effects

Synapse ◽

10.1002/syn.20819 ◽

2010 ◽

Vol 65 (1) ◽

pp. 77-83 ◽

Cited By ~ 3

Author(s):

Masashi Ueda ◽

Yasuhiko Iida ◽

Tomoki Yoneyama ◽

Tomoki Kawai ◽

Mikako Ogawa ◽

...

Keyword(s):

Neuropathic Pain ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Rat Model ◽

Receptor Occupancy ◽

Agonist Binding ◽

Nicotinic Acetylcholine ◽

Occupancy Rates

Download Full-text

Structural Determinants of 4 2 Nicotinic Acetylcholine Receptor Trafficking

Journal of Neuroscience ◽

10.1523/jneurosci.1079-05.2005 ◽

2005 ◽

Vol 25 (28) ◽

pp. 6676-6686 ◽

Cited By ~ 39

Author(s):

X.-Q. Ren

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Trafficking ◽

Structural Determinants ◽

Nicotinic Acetylcholine

Download Full-text

Structural discrimination between the two agonist binding sites of the Torpedo nicotinic acetylcholine receptor using time resolved fluorescence

Journal of Physiology-Paris ◽

10.1016/s0928-4257(99)80082-5 ◽

1998 ◽

Vol 92 (5-6) ◽

pp. 466

Author(s):

K. Martinez ◽

P.J. Corringer ◽

F. Merola ◽

J.-P. Changeux

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Binding Sites ◽

Agonist Binding ◽

Time Resolved Fluorescence ◽

Nicotinic Acetylcholine ◽

Time Resolved

Download Full-text

Nicotinic acetylcholine receptor chimeras of rat α7 andDrosophilaSAD reveal species-specific agonist binding regions

Pesticide Science ◽

10.1002/(sici)1096-9063(199910)55:10<1031::aid-ps42>3.0.co;2-q ◽

1999 ◽

Vol 55 (10) ◽

pp. 1031-1033 ◽

Cited By ~ 1

Author(s):

Ingeborg van den Beukel ◽

Remco Klaassen ◽

Guus B Smit ◽

Regina G D M van Kleef ◽

Marga Oortgiesen

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Agonist Binding ◽

Nicotinic Acetylcholine ◽

Binding Regions ◽

Species Specific ◽

Receptor Chimeras

Download Full-text

3P-085 Molecular recognition of barbiturate enantiomer in agonist binding site of nicotinic acetylcholine receptor(The 46th Annual Meeting of the Biophysical Society of Japan)

Seibutsu Butsuri ◽

10.2142/biophys.48.s140_4 ◽

2008 ◽

Vol 48 (supplement) ◽

pp. S140

Author(s):

Masayuki Ozaki ◽

Tomoyoshi Seto

Keyword(s):

Molecular Recognition ◽

Binding Site ◽

Annual Meeting ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Agonist Binding ◽

Nicotinic Acetylcholine ◽

Biophysical Society

Download Full-text

Mapping the Agonist Binding Site of the Nicotinic Acetylcholine Receptor

Journal of Biological Chemistry ◽

10.1074/jbc.275.17.12651 ◽

2000 ◽

Vol 275 (17) ◽

pp. 12651-12660 ◽

Cited By ~ 37

Author(s):

Deirdre A. Sullivan ◽

Jonathan B. Cohen

Keyword(s):

Binding Site ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Agonist Binding ◽

Nicotinic Acetylcholine

Download Full-text

Octahydropyrrolo[3,4-c]pyrrole: A Diamine Scaffold for Construction of Either α4β2 or α7-Selective Nicotinic Acetylcholine Receptor (nAChR) Ligands. Substitutions that Switch Subtype Selectivity

Journal of Medicinal Chemistry ◽

10.1021/jm900249k ◽

2009 ◽

Vol 52 (14) ◽

pp. 4126-4141 ◽

Cited By ~ 15

Author(s):

William H. Bunnelle ◽

Karin R. Tietje ◽

Jennifer M. Frost ◽

Dan Peters ◽

Jianguo Ji ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Subtype Selectivity

Download Full-text

Primary structure of an agonist binding subunit of the nicotinic acetylcholine receptor from bovine adrenal chromaffin cells

Neurochemical Research ◽

10.1007/bf00966671 ◽

1992 ◽

Vol 17 (3) ◽

pp. 281-287 ◽

Cited By ~ 52

Author(s):

Manuel Criado ◽

Leonor Alamo ◽

Angel Navarro

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Primary Structure ◽

Chromaffin Cells ◽

Adrenal Chromaffin Cells ◽

Agonist Binding ◽

Nicotinic Acetylcholine ◽

Adrenal Chromaffin ◽

Binding Subunit

Download Full-text