Octahydropyrrolo[3,4-c]pyrrole: A Diamine Scaffold for Construction of Either α4β2 or α7-Selective Nicotinic Acetylcholine Receptor (nAChR) Ligands. Substitutions that Switch Subtype Selectivity

William H. Bunnelle; Karin R. Tietje; Jennifer M. Frost; Dan Peters; Jianguo Ji; Tao Li; Marc J. C. Scanio; Lei Shi; David J. Anderson; Tino Dyhring; Jens H. Grønlien; Hilde Ween; Kirsten Thorin-Hagene; Michael D. Meyer

doi:10.1021/jm900249k

Octahydropyrrolo[3,4-c]pyrrole: A Diamine Scaffold for Construction of Either α4β2 or α7-Selective Nicotinic Acetylcholine Receptor (nAChR) Ligands. Substitutions that Switch Subtype Selectivity

Journal of Medicinal Chemistry ◽

10.1021/jm900249k ◽

2009 ◽

Vol 52 (14) ◽

pp. 4126-4141 ◽

Cited By ~ 15

Author(s):

William H. Bunnelle ◽

Karin R. Tietje ◽

Jennifer M. Frost ◽

Dan Peters ◽

Jianguo Ji ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Subtype Selectivity

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Key Structural Determinants in the Agonist Binding Loops of Human β2 and β4 Nicotinic Acetylcholine Receptor Subunits Contribute to α3β4 Subtype Selectivity of α-Conotoxins

Journal of Biological Chemistry ◽

10.1074/jbc.m116.730804 ◽

2016 ◽

Vol 291 (45) ◽

pp. 23779-23792 ◽

Cited By ~ 11

Author(s):

Hartmut Cuny ◽

Shiva N. Kompella ◽

Han-Shen Tae ◽

Rilei Yu ◽

David J. Adams

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Agonist Binding ◽

Structural Determinants ◽

Nicotinic Acetylcholine ◽

Subtype Selectivity

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Profile of nicotinic acetylcholine receptor agonists ABT-594 and A-582941, with differential subtype selectivity, on delayed matching accuracy by young monkeys

Biochemical Pharmacology ◽

10.1016/j.bcp.2007.07.010 ◽

2007 ◽

Vol 74 (8) ◽

pp. 1202-1211 ◽

Cited By ~ 38

Author(s):

Jerry J. Buccafusco ◽

Alvin V. Terry ◽

Michael W. Decker ◽

Murali Gopalakrishnan

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Matching Accuracy ◽

Nicotinic Acetylcholine ◽

Delayed Matching ◽

Receptor Agonists ◽

Subtype Selectivity

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Efficacy of Varenicline, an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist, vs Placebo or Sustained-Release Bupropion for Smoking Cessation: A Randomized Controlled Trial

Yearbook of Pulmonary Disease ◽

10.1016/s8756-3452(08)70598-x ◽

2008 ◽

Vol 2008 ◽

pp. 109-110

Author(s):

L.T. Tanoue

Keyword(s):

Randomized Controlled Trial ◽

Smoking Cessation ◽

Sustained Release ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Partial Agonist ◽

Controlled Trial ◽

Nicotinic Acetylcholine ◽

Randomized Controlled

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Varenicline, an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist, vs Sustained-Release Bupropion and Placebo for Smoking Cessation: A Randomized Controlled Trial

Yearbook of Medicine ◽

10.1016/s0084-3873(08)70096-8 ◽

2007 ◽

Vol 2007 ◽

pp. 143-145

Author(s):

N.H. Hanna

Keyword(s):

Randomized Controlled Trial ◽

Smoking Cessation ◽

Sustained Release ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Partial Agonist ◽

Controlled Trial ◽

Nicotinic Acetylcholine ◽

Randomized Controlled

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Faculty Opinions recommendation of Decreased signs of nicotine withdrawal in mice null for the beta4 nicotinic acetylcholine receptor subunit.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1022312.254647 ◽

2004 ◽

Author(s):

Marina Picciotto

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Nicotine Withdrawal ◽

Receptor Subunit ◽

Nicotinic Acetylcholine

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Faculty Opinions recommendation of Peptide-toxin tools for probing the expression and function of fetal and adult subtypes of the nicotinic acetylcholine receptor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1116372.572388 ◽

2008 ◽

Author(s):

David J Adams

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Peptide Toxin ◽

And Function

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Faculty Opinions recommendation of Alpha7 nicotinic acetylcholine receptor activation ameliorates scopolamine-induced behavioural changes in a modified continuous Y-maze task in mice.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1146929.604026 ◽

2009 ◽

Author(s):

Jerry Buccafusco

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Activation ◽

Maze Task ◽

Nicotinic Acetylcholine ◽

Alpha7 Nicotinic Acetylcholine Receptor ◽

Behavioural Changes ◽

Y Maze

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Faculty Opinions recommendation of A novel nicotinic acetylcholine receptor subtype in basal forebrain cholinergic neurons with high sensitivity to amyloid peptides.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1147992.605097 ◽

2009 ◽

Author(s):

Jerry Buccafusco

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Basal Forebrain ◽

Cholinergic Neurons ◽

High Sensitivity ◽

Receptor Subtype ◽

Nicotinic Acetylcholine ◽

Amyloid Peptides ◽

Basal Forebrain Cholinergic Neurons

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Faculty Opinions recommendation of A novel nicotinic acetylcholine receptor subtype in basal forebrain cholinergic neurons with high sensitivity to amyloid peptides.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1147992.1706087 ◽

2010 ◽

Author(s):

Mark A Smith ◽

Sonia Correia

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Basal Forebrain ◽

Cholinergic Neurons ◽

High Sensitivity ◽

Receptor Subtype ◽

Nicotinic Acetylcholine ◽

Amyloid Peptides ◽

Basal Forebrain Cholinergic Neurons

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Faculty Opinions recommendation of Nicotinic acetylcholine receptor β2 subunits in the medial prefrontal cortex control attention.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.12746958.14701060 ◽

2011 ◽

Author(s):

Michael Ehlers

Keyword(s):

Prefrontal Cortex ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Medial Prefrontal Cortex ◽

Nicotinic Acetylcholine

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