X-ray Structures of Progesterone Receptor Ligand Binding Domain in Its Agonist State Reveal Differing Mechanisms for Mixed Profiles of 11β-Substituted Steroids

Scott J. Lusher; Hans C. A. Raaijmakers; Diep Vu-Pham; Bert Kazemier; Rolien Bosch; Ross McGuire; Rita Azevedo; Hans Hamersma; Koen Dechering; Arthur Oubrie; Marcel van Duin; Jacob de Vlieg

doi:10.1074/jbc.m111.308403

X-ray Structures of Progesterone Receptor Ligand Binding Domain in Its Agonist State Reveal Differing Mechanisms for Mixed Profiles of 11β-Substituted Steroids

Journal of Biological Chemistry ◽

10.1074/jbc.m111.308403 ◽

2012 ◽

Vol 287 (24) ◽

pp. 20333-20343 ◽

Cited By ~ 19

Author(s):

Scott J. Lusher ◽

Hans C. A. Raaijmakers ◽

Diep Vu-Pham ◽

Bert Kazemier ◽

Rolien Bosch ◽

...

Keyword(s):

Progesterone Receptor ◽

Ligand Binding ◽

Binding Domain ◽

Ligand Binding Domain ◽

Receptor Ligand ◽

X Ray

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Crystallization and preliminary X-ray diffraction studies of isoform α1 of the human thyroid hormone receptor ligand-binding domain

Acta Crystallographica Section D Biological Crystallography ◽

10.1107/s0907444904017858 ◽

2004 ◽

Vol 60 (10) ◽

pp. 1867-1870 ◽

Cited By ~ 5

Author(s):

F. M. Nunes ◽

R. Aparicio ◽

M. A. M. Santos ◽

R. V. Portugal ◽

S. M. G. Dias ◽

...

Keyword(s):

Thyroid Hormone ◽

Ligand Binding ◽

Hormone Receptor ◽

Thyroid Hormone Receptor ◽

Binding Domain ◽

Ligand Binding Domain ◽

Human Thyroid ◽

X Ray Diffraction ◽

Receptor Ligand ◽

X Ray

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Progesterone receptor ligand binding domain : from conformational dynamics to drug discovery

10.32657/10220/48075 ◽

2019 ◽

Author(s):

Liangzhen Zheng

Keyword(s):

Drug Discovery ◽

Progesterone Receptor ◽

Ligand Binding ◽

Conformational Dynamics ◽

Binding Domain ◽

Ligand Binding Domain ◽

Receptor Ligand

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Ligand Binding Induces Agonistic-Like Conformational Adaptations in Helix 12 of Progesterone Receptor Ligand Binding Domain

Frontiers in Chemistry ◽

10.3389/fchem.2019.00315 ◽

2019 ◽

Vol 7 ◽

Cited By ~ 1

Author(s):

Liangzhen Zheng ◽

Kelin Xia ◽

Yuguang Mu

Keyword(s):

Progesterone Receptor ◽

Ligand Binding ◽

Binding Domain ◽

Ligand Binding Domain ◽

Receptor Ligand ◽

Helix 12

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X-ray Crystal Structure of the Novel Enhanced-Affinity Glucocorticoid Agonist Fluticasone Furoate in the Glucocorticoid Receptor−Ligand Binding Domain⊥

Journal of Medicinal Chemistry ◽

10.1021/jm800279t ◽

2008 ◽

Vol 51 (12) ◽

pp. 3349-3352 ◽

Cited By ~ 67

Author(s):

Keith Biggadike ◽

Randy K. Bledsoe ◽

Anne M. Hassell ◽

Barrie E. Kirk ◽

Iain M. McLay ◽

...

Keyword(s):

Crystal Structure ◽

Glucocorticoid Receptor ◽

Ligand Binding ◽

Binding Domain ◽

Ligand Binding Domain ◽

The Novel ◽

Fluticasone Furoate ◽

Receptor Ligand ◽

X Ray

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Solution X-ray Scattering Evidence for Agonist- and Antagonist-induced Modulation of Cleft Closure in a Glutamate Receptor Ligand-binding Domain

Journal of Biological Chemistry ◽

10.1074/jbc.m414523200 ◽

2005 ◽

Vol 280 (25) ◽

pp. 23637-23642 ◽

Cited By ~ 19

Author(s):

Dean R. Madden ◽

Neali Armstrong ◽

Dmitri Svergun ◽

Javier Pérez ◽

Patrice Vachette

Keyword(s):

Ligand Binding ◽

Glutamate Receptor ◽

Binding Domain ◽

Ligand Binding Domain ◽

Receptor Ligand ◽

X Ray ◽

X Ray Scattering ◽

Agonist And Antagonist ◽

Cleft Closure ◽

Ray Scattering

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Faculty Opinions recommendation of X-ray crystal structure of the novel enhanced-affinity glucocorticoid agonist fluticasone furoate in the glucocorticoid receptor-ligand binding domain.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1111151.572750 ◽

2008 ◽

Author(s):

Robert Fecik

Keyword(s):

Crystal Structure ◽

Glucocorticoid Receptor ◽

Ligand Binding ◽

Binding Domain ◽

Ligand Binding Domain ◽

The Novel ◽

Fluticasone Furoate ◽

Receptor Ligand ◽

X Ray

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Investigation of the binding interactions of progesterone using muteins of the human progesterone receptor ligand binding domain designed on the basis of a three-dimensional protein model

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology ◽

10.1016/s0167-4838(98)00249-0 ◽

1999 ◽

Vol 1429 (2) ◽

pp. 391-400 ◽

Cited By ~ 13

Author(s):

Miriam Letz ◽

Peter Bringmann ◽

Mario Mann ◽

Anke Mueller-Fahrnow ◽

Dania Reipert ◽

...

Keyword(s):

Progesterone Receptor ◽

Ligand Binding ◽

Three Dimensional ◽

Binding Domain ◽

Ligand Binding Domain ◽

Receptor Ligand ◽

Binding Interactions ◽

Protein Model ◽

Human Progesterone Receptor

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Exploring Flexibility of Progesterone Receptor Ligand Binding Domain Using Molecular Dynamics

PLoS ONE ◽

10.1371/journal.pone.0165824 ◽

2016 ◽

Vol 11 (11) ◽

pp. e0165824 ◽

Cited By ~ 10

Author(s):

Liangzhen Zheng ◽

Valerie Chunling Lin ◽

Yuguang Mu

Keyword(s):

Molecular Dynamics ◽

Progesterone Receptor ◽

Ligand Binding ◽

Binding Domain ◽

Ligand Binding Domain ◽

Receptor Ligand

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Crystallization and preliminary X-ray analysis of the human androgen receptor ligand-binding domain with a coactivator-like peptide and selective androgen receptor modulators

Acta Crystallographica Section F Structural Biology and Crystallization Communications ◽

10.1107/s1744309108036683 ◽

2008 ◽

Vol 64 (12) ◽

pp. 1159-1162

Author(s):

Maxime Thauvin ◽

Catherine Robin-Jagerschmidt ◽

François Nique ◽

Patrick Mollat ◽

Damien Fleury ◽

...

Keyword(s):

Androgen Receptor ◽

Ligand Binding ◽

Binding Domain ◽

Ligand Binding Domain ◽

Receptor Ligand ◽

X Ray ◽

Selective Androgen Receptor Modulators ◽

Receptor Modulators ◽

Human Androgen Receptor

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Ab initio fragment molecular orbital study of ligand binding to human progesterone receptor ligand-binding domain

Naunyn-Schmiedeberg s Archives of Pharmacology ◽

10.1007/s00210-008-0268-9 ◽

2008 ◽

Vol 377 (4-6) ◽

pp. 607-615 ◽

Cited By ~ 12

Author(s):

Takanori Harada ◽

Kenji Yamagishi ◽

Tatsuya Nakano ◽

Kazuo Kitaura ◽

Hiroaki Tokiwa

Keyword(s):

Progesterone Receptor ◽

Ligand Binding ◽

Ab Initio ◽

Molecular Orbital ◽

Binding Domain ◽

Ligand Binding Domain ◽

Receptor Ligand ◽

Molecular Orbital Study ◽

Orbital Study ◽

Human Progesterone Receptor

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