scholarly journals Sorting Nexin 27 Protein Regulates Trafficking of a p21-activated Kinase (PAK) Interacting Exchange Factor (β-Pix)-G Protein-coupled Receptor Kinase Interacting Protein (GIT) Complex via a PDZ Domain Interaction

2011 ◽  
Vol 286 (45) ◽  
pp. 39403-39416 ◽  
Author(s):  
Julie L. Valdes ◽  
Jingrong Tang ◽  
Mark I. McDermott ◽  
Jean-Cheng Kuo ◽  
Seth P. Zimmerman ◽  
...  
Keyword(s):  
G Protein ◽  
Pdz Domain ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
Domain Interaction ◽  
Interacting Protein ◽  
Sorting Nexin ◽  
Exchange Factor ◽  
P21 Activated Kinase ◽  
G Protein Coupled

scholarly journals Coupling of PAK-Interacting Exchange Factor PIX to GIT1 Promotes Focal Complex Disassembly

2000 ◽  
Vol 20 (17) ◽  
pp. 6354-6363 ◽  
Author(s):  
Zhou-shen Zhao ◽  
Edward Manser ◽  
Tsui-Han Loo ◽  
Louis Lim
Keyword(s):  
Complex Dynamics ◽  
Direct Interaction ◽  
Receptor Kinase ◽  
Interacting Protein ◽  
Sh3 Domains ◽  
Exchange Factor ◽  
Activated State ◽  
Focal Complex ◽  
P21 Activated Kinase ◽  
G Protein Coupled

ABSTRACT The p21-activated kinase PAK is targeted to focal complexes (FCs) through interactions with the SH3 domains of the PAK-interacting exchange factor PIX and Nck. PIX is a Rac GTP exchange factor that also binds the G-protein-coupled receptor kinase-interacting protein known as GIT1. Overexpression of GIT1 in fibroblasts or epithelial cells causes a loss of paxillin from FCs and stimulates cell motility. This is due to the direct interaction of a C-terminal 125-residue domain of GIT1 with paxillin, under the regulation of PIX. In its activated state, GIT1 can promote FC disassembly independent of actin-myosin contractile events. Additionally, GIT directly couples to a key component of FCs, focal adhesion kinase (FAK), via a conserved Spa2 homology domain. We propose that GIT1 and FAK cooperate to promote motility both by directly regulating focal complex dynamics and by the activation of Rac.

scholarly journals G Protein-coupled Receptor Kinase 6A Phosphorylates the Na+/H+Exchanger Regulatory Factor via a PDZ Domain-mediated Interaction

1999 ◽  
Vol 274 (34) ◽  
pp. 24328-24334 ◽  
Author(s):  
Randy A. Hall ◽  
Robert F. Spurney ◽  
Richard T. Premont ◽  
Nadeem Rahman ◽  
Jeremy T. Blitzer ◽  
...  
Keyword(s):  
G Protein ◽  
Pdz Domain ◽  
Receptor Kinase ◽  
Regulatory Factor ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals G-Protein–Coupled Receptor Kinase Interacting Protein-1 Is Required for Pulmonary Vascular Development

Circulation ◽  
2009 ◽  
Vol 119 (11) ◽  
pp. 1524-1532 ◽  
Author(s):  
Jinjiang Pang ◽  
Ryan Hoefen ◽  
Gloria S. Pryhuber ◽  
Jing Wang ◽  
Guoyong Yin ◽  
...  
Keyword(s):  
G Protein ◽  
Vascular Development ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
Interacting Protein ◽  
G Protein Coupled ◽  
Pulmonary Vascular Development
Sign in / Sign up

Export Citation Format

Share Document