scholarly journals Tumor Suppressor Menin Represses Paired Box Gene 2 Expression via Wilms Tumor Suppressor Protein-Polycomb Group Complex

2011 ◽  
Vol 286 (16) ◽  
pp. 13937-13944 ◽  
Author(s):  
Bin Xu ◽  
De-quan Zeng ◽  
Yuan Wu ◽  
Rong Zheng ◽  
Le Gu ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Wilms Tumor ◽  
Polycomb Group ◽  
Tumor Suppressor Protein

scholarly journals Characterization of the Zn(II) Binding Properties of the Human Wilms’ Tumor Suppressor Protein C-terminal Zinc Finger Peptide

2014 ◽  
Vol 53 (12) ◽  
pp. 6309-6320 ◽  
Author(s):  
Ka Lam Chan ◽  
Inna Bakman ◽  
Amy R. Marts ◽  
Yuksel Batir ◽  
Terry L. Dowd ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Zinc Finger ◽  
Protein C ◽  
Wilms Tumor ◽  
Tumor Suppressor Protein ◽  
Binding Properties ◽  
Zinc Finger Peptide

Characterization of RNA Aptamer Binding by the Wilms' Tumor Suppressor Protein WT1†

Biochemistry ◽  
2001 ◽  
Vol 40 (7) ◽  
pp. 2032-2040 ◽  
Author(s):  
Gary Zhai ◽  
Maya Iskandar ◽  
Kathleen Barilla ◽  
Paul J. Romaniuk
Keyword(s):  
Tumor Suppressor ◽  
Wilms Tumor ◽  
Tumor Suppressor Protein ◽  
Rna Aptamer

scholarly journals The Wilms' Tumor Suppressor Protein WT1 Is Processed by the Serine Protease HtrA2/Omi

2010 ◽  
Vol 37 (2) ◽  
pp. 159-171 ◽  
Author(s):  
Jörg Hartkamp ◽  
Brian Carpenter ◽  
Stefan G.E. Roberts
Keyword(s):  
Tumor Suppressor ◽  
Serine Protease ◽  
Wilms Tumor ◽  
Tumor Suppressor Protein

scholarly journals BASP1 Is a Transcriptional Cosuppressor for the Wilms' Tumor Suppressor Protein WT1

2004 ◽  
Vol 24 (2) ◽  
pp. 537-549 ◽  
Author(s):  
Brian Carpenter ◽  
Kathryn J. Hill ◽  
Marika Charalambous ◽  
Kate J. Wagner ◽  
Diya Lahiri ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Transcriptional Activation ◽  
Transcriptional Activity ◽  
Direct Evidence ◽  
Wilms Tumor ◽  
Tumor Suppressor Protein ◽  
Functional Assay ◽  
Transcriptional Activation Domain ◽  
Adult Kidney ◽  
Suppression Region

ABSTRACT The Wilms' tumor suppressor protein WT1 is a transcriptional regulator that plays a key role in the development of the kidneys. The transcriptional activation domain of WT1 is subject to regulation by a suppression region within the N terminus of WT1. Using a functional assay, we provide direct evidence that this requires a transcriptional cosuppressor, which we identify as brain acid soluble protein 1 (BASP1). WT1 and BASP1 associate within the nuclei of cells that naturally express both proteins. BASP1 can confer WT1 cosuppressor activity in transfection assays, and elimination of endogenous BASP1 expression augments transcriptional activation by WT1. BASP1 is present in the developing nephron structures of the embryonic kidney and, coincident with that of WT1, its expression is restricted to the highly specialized podocyte cells of the adult kidney. Taken together, our results show that BASP1 is a WT1-associated factor that can regulate WT1 transcriptional activity.

Effects of Denys−Drash Syndrome Point Mutations on the DNA Binding Activity of the Wilms' Tumor Suppressor Protein WT1†

Biochemistry ◽  
1996 ◽  
Vol 35 (37) ◽  
pp. 12070-12076 ◽  
Author(s):  
Franck Borel ◽  
Kathleen C. Barilla ◽  
Tatyana B. Hamilton ◽  
May Iskandar ◽  
Paul J. Romaniuk
Keyword(s):  
Tumor Suppressor ◽  
Dna Binding ◽  
Wilms Tumor ◽  
Point Mutations ◽  
Binding Activity ◽  
Tumor Suppressor Protein ◽  
Dna Binding Activity ◽  
Drash Syndrome

Characterization of Monoclonal Antibodies Directed to the Amino-Terminus of the WT1, Wilms' Tumor Suppressor Protein

Hybridoma ◽  
1998 ◽  
Vol 17 (2) ◽  
pp. 191-198 ◽  
Author(s):  
FRANK J. RAUSCHER ◽  
JENNIFER F. MORRIS ◽  
WILLIAM J. FREDERICKS ◽  
JESUS LOPEZ-GUISA ◽  
CHRISTOPHER BALAKRISHNAN ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Tumor Suppressor ◽  
Wilms Tumor ◽  
Tumor Suppressor Protein ◽  
Amino Terminus
Sign in / Sign up

Export Citation Format

Share Document