scholarly journals Preferential Inhibition of BMAL2-CLOCK Activity by PER2 Reemphasizes Its Negative Role and a Positive Role of BMAL2 in the Circadian Transcription

2009 ◽  
Vol 284 (37) ◽  
pp. 25149-25159 ◽  
Author(s):  
Momoko Sasaki ◽  
Hikari Yoshitane ◽  
Ngoc-Hien Du ◽  
Toshiyuki Okano ◽  
Yoshitaka Fukada
Keyword(s):  
Positive Role ◽  
Negative Role ◽  
Circadian Transcription

scholarly journals SERANGGA dan PERANANNYA DALAM BIDANG PERTANIAN dan KEHIDUPAN

2016 ◽  
Vol 1 (1) ◽  
pp. 18
Author(s):  
Araz Meilin ◽  
Nasamsir .
Keyword(s):  
Natural Enemies ◽  
Positive Role ◽  
Living Thing ◽  
Disease Vector ◽  
Number Of Species ◽  
Negative Role

AbstractThe insect is a group of living thing that have the largest number of species. This article was compiled by aiming literature method studies at informing the negative and positive roles of insects in a farming and life. Some insects have a positive or negative role in agriculture and life. The negative role of insects in agriculture and life as cultivation plant, as a disease vector on the plant, and it cause humand being stickness. The positive role of insect is as pollinators, as a decomposer, as predators or parasitoids, as environment bioindikator, as the producer of the useful materials and beneficial in the field of health. Keywords: insects, vectors, natural enemies, pollinators, decomposer AbstrakSerangga merupakan kelompok makhluk hidup yang memiliki jumlah spesies terbanyak. Tulisan ini disusun dari studi literatur dan bertujuan menginformasikan peran negatif dan positif serangga dalam bidang pertanian dan kehidupan.  Beberapa anggota dari serangga memiliki peranan positif maupun negatif di bidang pertanian dan kehidupan.  Peran negatif serangga dibidang pertanian dan kehidupan adalah sebagai pemakan tumbuhan budidaya, sebagai vektor penyebab penyakit pada tanaman, dan sebagai penyebab penyakit pada manusia. Peran positif serangga adalah sebagai polinator atau penyerbuk, sebagai dekomposer atau pengurai, sebagai predator atau parasitoid (musuh alami), sebagai bioindikator lingkungan, sebagai penghasil bahan-bahan berguna dan bermanfaat  dalam bidang kesehatan. Kata Kunci: serangga, vektor, musuh alami, polinator, dekomposer

scholarly journals The ST2/Interleukin-33 Axis in Hematologic Malignancies: The IL-33 Paradox

2019 ◽  
Vol 20 (20) ◽  
pp. 5226 ◽  
Author(s):  
Alessandro Allegra ◽  
Vanessa Innao ◽  
Gennaro Tartarisco ◽  
Giovanni Pioggia ◽  
Marco Casciaro ◽  
...  
Keyword(s):  
Immune Responses ◽  
Myeloid Leukemia ◽  
Hematological Malignancies ◽  
Cell Damage ◽  
Hematologic Malignancies ◽  
Positive Role ◽  
Interleukin 33 ◽  
Relevant Role ◽  
Negative Role

Interleukin (IL)-33 is a chromatin-related nuclear interleukin that is a component of IL-1 family. IL-33 production augments the course of inflammation after cell damage or death. It is discharged into the extracellular space. IL-33 is regarded as an “alarmin” able to stimulate several effectors of the immune system, regulating numerous immune responses comprising cancer immune reactions. IL-33 has been demonstrated to influence tumorigenesis. However, as far as this cytokine is concerned, we are faced with what has sometimes been defined as the IL-33 paradox. Several studies have demonstrated a relevant role of IL-33 to numerous malignancies, where it may have pro- and—less frequently—antitumorigenic actions. In the field of hematological malignancies, the role of IL-33 seems even more complex. Although we can affirm the existence of a negative role of IL-33 in Chronic myelogenos leukemia (CML) and in lymphoproliferative diseases and a positive role in pathologies such as Acute myeloid leukemia (AML), the action of IL-33 seems to be multiple and sometimes contradictory within the same pathology. In the future, we will have to learn to govern the negative aspects of activating the IL-33/ST2 axis and exploit the positive ones.

The Network Constellation of Personality and Substance Use: Evolution from Early to Late Adolescence

2020 ◽  
Vol 34 (6) ◽  
pp. 1109-1119 ◽  
Author(s):  
Mohammad H. Afzali ◽  
Sherry Heather Stewart ◽  
Jean R. Séguin ◽  
Patricia Conrod
Keyword(s):  
Substance Use ◽  
Alcohol Use ◽  
Graphical Models ◽  
Anxiety Sensitivity ◽  
Sensation Seeking ◽  
Late Adolescence ◽  
Positive Role ◽  
Personality Psychology ◽  
Negative Role

There is a well–established link between substance use and four personality traits of anxiety–sensitivity, hopelessness, impulsivity, and sensation–seeking. However, construct–level models of personality may conceal indicator–level personality–outcome associations. The current study aims to investigate evolution of the network constellation of personality and cannabis/alcohol use from early to late adolescence. Data comes from the longitudinal Co–Venture cohort (N = 3800). Personality indicators, measured by Substance Use Risk Profile Scale (SURPS) items, and the frequency of cannabis/alcohol use were assessed at four consecutive years (13–17 years old). Network constellations of the SURPS items and cannabis/alcohol use were estimated using Bayesian Gaussian graphical models at four time points. Results highlighted the age–specific associations between personality indicators and substance use. The positive role of the sensation–seeking trait (e.g. attitude towards transgression) was constant, whereas the positive role of hopelessness indicators (e.g. not being enthusiastic about future) and the negative role of anxiety–sensitivity indicators (e.g. fear of having unusual body sensations) were more prominent at early adolescence. The current study provides a novel perspective on the network structure of personality and substance use in adolescence and suggests substance–specific and age–adjusted targets in intervention efforts. © 2020 European Association of Personality Psychology

scholarly journals Freedom of expression -The Clash of Rights

2021 ◽  
Vol 8 (7) ◽  
pp. 516-521
Author(s):  
Andhika Yahya Santiago Baramuli
Keyword(s):  
Freedom Of Expression ◽  
Modern Democracy ◽  
Positive Role ◽  
Negative Role ◽  
The Right

This article will examine the shift in the role of freedom of expression based on recent events, observing how the right to freedom guaranteed by law has shifted into a coercive political tool in modern democracy. The results of this article show that, freedom of expression has been melted and shaped into a shield into a sword. This has changed from what was traditionally a negative role to guarantee people's freedom from arbitrary exercise of power, to a positive role in which people can exercise their liberties against their own rights.

L1 and L2 transfer to L3 in L3 and L2 learners of Standard Arabic

2019 ◽  
Vol 10 (6) ◽  
pp. 745-774
Author(s):  
Abdulkafi Albirini ◽  
Eman Saadah ◽  
Mohammad T. Alhawary
Keyword(s):  
Definite Article ◽  
Positive Role ◽  
Standard Arabic ◽  
Sentential Negation ◽  
L2 Learners ◽  
Negative Role ◽  
Colloquial Arabic ◽  
L1 And L2 ◽  
L1 English

Abstract This study examines the influence of previously acquired languages – namely, Colloquial Arabic (CA) and English – on the acquisition of Standard Arabic (SA) by L3 and L2 learners. It reports on the role of typological and structural proximity in language transfer and whether transfer patterns change over time. The study involved 105 participants: 41 CA-L1, English-L2 learners of SA, 47 English-L1 learners of SA, and 17 Arabic-L1 speakers. The participants completed three written tasks focusing on: definite article use, verb subcategorization rules, and sentential negation. The results indicate that CA plays a positive role in L3 learners’ acquisition of SA, mainly in forms where SA and CA converge, whereas English seems to play more of a negative role for both L3 and L2 learners. Thus, structural proximity seems to play a positive role in transfer to the L3. Negative transfer, irrespective of proximity/distance, diminishes as learners advance in their study of SA.

In What Sense are Errors in Philosophy ‘Only Ridiculous’?

2014 ◽  
Vol 12 (2) ◽  
pp. 213-229
Author(s):  
Lisa Ievers
Keyword(s):  
Critical Role ◽  
Standard Interpretation ◽  
Positive Role ◽  
Philosophical Reflection ◽  
Negative Role ◽  
Practical Life

In one of the closing paragraphs of Treatise Book 1, Hume provocatively concludes: ‘Generally speaking, the errors in religion are dangerous; those in philosophy only ridiculous’ (THN 1.4.7.13: 272). Unlike the first clause, the meaning of the second clause is far from obvious. I claim that errors in philosophy are ‘only ridiculous’ for Hume in the sense that – unlike errors in religion – they fail to disturb us psychologically or in practical life. The interesting question, however, is why they fail to disturb us. I suggest that it is their critical role in resolving the psychological instability brought on by philosophical reflection that makes errors in philosophy quite helpful to us and necessary for re-stabilising ourselves. In recognising a positive role for philosophical errors, my account challenges the standard interpretation of Hume's claim according to which ‘ridiculous’ philosophical errors play the merely negative role of being innocuous or safely dismissed.

scholarly journals Leadership Styles and Team Performance

2021 ◽  
Vol 3 (26) ◽  
pp. 74-85
Author(s):  
Dr. Fahad Saad Soliaman Algorabi Alharbi ◽  
Keyword(s):  
Transformational Leadership ◽  
Leadership Styles ◽  
Transactional Leadership ◽  
Team Performance ◽  
Positive Role ◽  
Future Researcher ◽  
Negative Role

This paper aims to study the relation between transformational leadership, transactional leadership and team performance. The researcher dependent on previous studies to conduct this research. The results refer to that transformational leadership has positive role on team performance however, transactional leadership has positive and negative role on team performance. Leaders have to strengthen the role of transformational leadership to improve and develop the team performance. For future, researcher recommended to conduct studies on transactional leadership and team performance.

scholarly journals PERAN IBU DALAM TOILET TRAINING PADA ANAK USIA TODDLER DI KECAMATAN KEMLAGI KABUPATEN MOJOKERTO

2019 ◽  
Vol 6 (3) ◽  
pp. 260-265
Author(s):  
Veryudha Eka Prameswari ◽  
Indah Kusmindarti ◽  
Linda Ajeng Lestari
Keyword(s):  
Frequency Distribution ◽  
Research Design ◽  
Toilet Training ◽  
Positive Role ◽  
Descriptive Research ◽  
T Score ◽  
Lack Of Information ◽  
Negative Role

Background : Toilet training in children was an effort to train children to be able to control the conduct defecation and urination. Exercise of defecation and urination in children need preparation, both physically, psychologically and intellectually, through this preparation expected that child was able to control defecation and urination independently. Objective : Purpose of this research to describe the role of mother in toilet training on children toddler olds in the Mojodadi village Kemlagi District of Mojokerto. Methods : Design of research was used descriptive research design. The method of sampling used total sampling (nonprobability sampling). Sample was taken all respondents as many as 82 respondents who have a toddler old of children in the Mojodadi village Kemlagi District of Mojokerto in June 2015. Data was collected by questionnaire instrument and then the data though as editing, coding, scoring, tabulating and was analyzed by T score then the results presented with Frequency Distribution Table. Results : The results was showed that the discribe role of mother in the toilet training on children toddler olds in the Mojodadi village Kemlagi District of Mojokerto as the respondents who had a negative role as much as 44 respondents (53.7%) while having a positive role as much as 38 respondents (46.3% ). Conclusions : A negative role due to the lack of information on how to train toilet training and the role of mother is also influenced their knowledge, education, age and occupation held by the respondents related to toilet training. Keywords: Toilet training, role, toddler

scholarly journals Migration Narratives: An Introduction to Part I, Exemplars

2020 ◽  
pp. 17-25
Author(s):  
Bill Fulford
Keyword(s):  
Mental Health ◽  
Protective Factors ◽  
Cultural Values ◽  
Health Issues ◽  
Positive Role ◽  
Mental Health Issues ◽  
Migration Narratives ◽  
Negative Role ◽  
Narrative Understanding

AbstractFour common themes about cultural values are identified as exemplified in different ways by the migration narratives presented in this Part: (1) their negative role: the role of cultural values as factors in the causes and presentation of a wide variety of mental health issues; (2) their positive role: the role of cultural values also as positive or protective factors and hence the need in mental health to balance negative and positive roles as they apply in a given individual’s story; (3) narrative understanding: the significance of narrative as a uniquely powerful way of understanding cultural and other values and the range of philosophical resources by which this role is supported; and (4) partnership with science: the essential partnership between values and science in mental health. The significance of these themes as they play out across the book as a whole is indicated.

The CoP’s Role in Introducing New Technology in Cultural Organizations

2021 ◽  
pp. 91-123
Author(s):  
Eman Alyousuf ◽  
◽  
Faris Almansour ◽  
Keyword(s):  
Qualitative Research ◽  
Community Of Practice ◽  
New Technology ◽  
Digital Transformation ◽  
Knowledge Generation ◽  
Positive Role ◽  
Academic Literature ◽  
Cultural Organizations ◽  
Negative Role

This study assessed the problem of the development of new technology and knowledge management in cultural organizations. The specific role of the community of practice (CoP) as an instrument of change management and knowledge generation in cultural organizations was considered. In terms of the study problem, qualitative research methods were used for the analysis of the academic literature and practical cases of libraries in Florida. The outcomes of the study demonstrated that the CoP did not play a negative role in the process of new technology integration in cultural organizations. In contrast, CoPs played a serious positive role thus generating ideas for innovations and supporting the personnel of libraries in their development. Concerning sources of barriers, the lack of resources, limited capabilities of librarians, and low support of management were considered the main issues. Further research should identify specific recommendations applicable for the improvement of the situation and sharing of the best experience in the sphere of digital transformation of cultural organizations.

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