scholarly journals Interaction between GC Box Binding Factors and Smad Proteins Modulates Cell Lineage-specific α2(I) Collagen Gene Transcription

2001 ◽  
Vol 276 (19) ◽  
pp. 16573-16579 ◽  
Author(s):  
Yutaka Inagaki ◽  
Tomoyuki Nemoto ◽  
Atsuhito Nakao ◽  
Peter ten Dijke ◽  
Kenichi Kobayashi ◽  
...  
Keyword(s):  
Gene Transcription ◽  
Cell Lineage ◽  
Collagen Gene ◽  
Smad Proteins ◽  
Gc Box

Changes in albumin, α-fetoprotein and collagen gene transcription in ccl4-induced hepatic fibrosis

Hepatology ◽  
1988 ◽  
Vol 8 (2) ◽  
pp. 259-266 ◽  
Author(s):  
Arturo Panduro ◽  
Fouad Shalaby ◽  
Luis Biempica ◽  
David A. Shafritz
Keyword(s):  
Hepatic Fibrosis ◽  
Gene Transcription ◽  
Collagen Gene

scholarly journals Prdm5 Regulates Collagen Gene Transcription by Association with RNA Polymerase II in Developing Bone

PLoS Genetics ◽  
2012 ◽  
Vol 8 (5) ◽  
pp. e1002711 ◽  
Author(s):  
Giorgio Giacomo Galli ◽  
Kristian Honnens de Lichtenberg ◽  
Matteo Carrara ◽  
Wolfgang Hans ◽  
Manuela Wuelling ◽  
...  
Keyword(s):  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Gene Transcription ◽  
Collagen Gene

scholarly journals SMAD proteins of oligodendroglial cells regulate transcription of JC virus early and late genes coordinately with the Tat protein of human immunodeficiency virus type 1

2009 ◽  
Vol 90 (8) ◽  
pp. 2005-2014 ◽  
Author(s):  
Michelle R. Stettner ◽  
Jonas A. Nance ◽  
Clayton A. Wright ◽  
Yayoi Kinoshita ◽  
Woong-Ki Kim ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Gene Transcription ◽  
Human Immunodeficiency Virus Type ◽  
Jc Virus ◽  
Tat Protein ◽  
Smad Proteins ◽  
Immunodeficiency Virus ◽  
The Brain ◽  
Hiv 1

JC virus (JCV) is the aetiological agent of progressive multifocal leukoencephalopathy (PML), a fatal, demyelinating disease of the brain affecting people with AIDS. Although immunosuppression is involved in infection of the brain by JCV, a direct influence of human immunodeficiency virus type 1 (HIV-1) has also been established. The Tat protein of HIV-1 has been implicated in activation of the cytokine transforming growth factor (TGF)-β in HIV-1-infected cells and in stimulating JCV gene transcription and DNA replication in oligodendroglia, the primary central nervous system cell type infected by JCV in PML. This study demonstrated that Tat can cooperate with SMAD proteins, the intracellular effectors of TGF-β, at the JCV DNA control region (CR) to stimulate JCV gene transcription. Tat stimulated JCV early gene transcription in KG-1 oligodendroglial cells when expressed via transfection or added exogenously. Using chromatin immunoprecipitation, it was shown that exogenous Tat enhanced binding of SMAD2, -3 and -4 and their binding partner Fast1 to the JCV CR in living cells. When SMAD2, -3 and -4 were expressed together, Tat, expressed from plasmid pTat, stimulated transcription from both early and late gene promoters, with the early promoter exhibiting stimulation of >100-fold. Tat, SMAD4 and JCV large T-antigen were all visualized in oligodendroglial cells at the border of an active PML lesion in the cerebral frontal lobe. These results revealed a positive reinforcement system in which the SMAD mediators of the TGF-β system act cooperatively with Tat to stimulate JCV gene transcription.

Albumin modified by Amadori glucose adducts activates mesangial cell type IV collagen gene transcription

1995 ◽  
Vol 151 (1) ◽  
pp. 61-67 ◽  
Author(s):  
Margo P. Cohen ◽  
Elizabeth Hud ◽  
Van-Yu Wu ◽  
Fuad N. Ziyadeh
Keyword(s):  
Gene Transcription ◽  
Type Iv Collagen ◽  
Mesangial Cell ◽  
Collagen Gene ◽  
Cell Type ◽  
Type Iv

Regulation of the α2(I) collagen gene transcription in fat-storing cells derived from a cirrhotic liver

Hepatology ◽  
1995 ◽  
Vol 22 (2) ◽  
pp. 573-579 ◽  
Author(s):  
Yutaka Inagaki ◽  
Sharada Truter ◽  
Patricia Greenwel ◽  
Marcos Rojkind ◽  
Masashi Unoura ◽  
...  
Keyword(s):  
Gene Transcription ◽  
Cirrhotic Liver ◽  
Collagen Gene

Interferon alfa down-regulates collagen gene transcription and suppresses experimental hepatic fibrosis in mice

Hepatology ◽  
2003 ◽  
Vol 38 (4) ◽  
pp. 890-899 ◽  
Author(s):  
Yutaka Inagaki ◽  
Tomoyuki Nemoto ◽  
Miwa Kushida ◽  
Yin Sheng ◽  
Kiyoshi Higashi ◽  
...  
Keyword(s):  
Hepatic Fibrosis ◽  
Gene Transcription ◽  
Interferon Alfa ◽  
Collagen Gene
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