Regulation of Na,K-ATPase α1 subunit gene transcription in response to low K+: Role of CRE/ATF- and GC box-binding proteins

2007 ◽  
Vol 213 (1) ◽  
pp. 167-176 ◽  
Author(s):  
Gang Wang ◽  
Kiyoshi Kawakami ◽  
Gregory Gick
Keyword(s):  
Gene Transcription ◽  
Binding Proteins ◽  
Subunit Gene ◽  
Gc Box ◽  
Low K ◽  
Α1 Subunit

Role of Fatty Acid Binding Proteins and Long Chain Fatty Acids in Modulating Nuclear Receptors and Gene Transcription

Lipids ◽  
2007 ◽  
Vol 43 (1) ◽  
pp. 1-17 ◽  
Author(s):  
Friedhelm Schroeder ◽  
Anca D. Petrescu ◽  
Huan Huang ◽  
Barbara P. Atshaves ◽  
Avery L. McIntosh ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Nuclear Receptors ◽  
Gene Transcription ◽  
Binding Proteins ◽  
Fatty Acid Binding Proteins ◽  
Long Chain Fatty Acids ◽  
Fatty Acid Binding ◽  
Long Chain

scholarly journals Ca2+ Microdomains, Calcineurin and the Regulation of Gene Transcription

Cells ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 875
Author(s):  
Gerald Thiel ◽  
Tobias Schmidt ◽  
Oliver G. Rössler
Keyword(s):  
Transcription Factors ◽  
Protein Kinase ◽  
Protein Kinases ◽  
Gene Transcription ◽  
Intracellular Signaling ◽  
Second Messengers ◽  
Major Function ◽  
Surface Receptors ◽  
Dependent Protein

Ca2+ ions function as second messengers regulating many intracellular events, including neurotransmitter release, exocytosis, muscle contraction, metabolism and gene transcription. Cells of a multicellular organism express a variety of cell-surface receptors and channels that trigger an increase of the intracellular Ca2+ concentration upon stimulation. The elevated Ca2+ concentration is not uniformly distributed within the cytoplasm but is organized in subcellular microdomains with high and low concentrations of Ca2+ at different locations in the cell. Ca2+ ions are stored and released by intracellular organelles that change the concentration and distribution of Ca2+ ions. A major function of the rise in intracellular Ca2+ is the change of the genetic expression pattern of the cell via the activation of Ca2+-responsive transcription factors. It has been proposed that Ca2+-responsive transcription factors are differently affected by a rise in cytoplasmic versus nuclear Ca2+. Moreover, it has been suggested that the mode of entry determines whether an influx of Ca2+ leads to the stimulation of gene transcription. A rise in cytoplasmic Ca2+ induces an intracellular signaling cascade, involving the activation of the Ca2+/calmodulin-dependent protein phosphatase calcineurin and various protein kinases (protein kinase C, extracellular signal-regulated protein kinase, Ca2+/calmodulin-dependent protein kinases). In this review article, we discuss the concept of gene regulation via elevated Ca2+ concentration in the cytoplasm and the nucleus, the role of Ca2+ entry and the role of enzymes as signal transducers. We give particular emphasis to the regulation of gene transcription by calcineurin, linking protein dephosphorylation with Ca2+ signaling and gene expression.

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