scholarly journals Dual Regulation of Akt/Protein Kinase B by Heterotrimeric G Protein Subunits

2000 ◽  
Vol 275 (49) ◽  
pp. 38870-38876 ◽  
Author(s):  
Rajani K. Bommakanti ◽  
Shaveta Vinayak ◽  
William F. Simonds
Keyword(s):  
Protein Kinase ◽  
G Protein ◽  
Protein Kinase B ◽  
Heterotrimeric G Protein ◽  
Protein Subunits

scholarly journals Activation of Protein Kinase D by Signaling through the α Subunit of the Heterotrimeric G Protein Gq

2000 ◽  
Vol 275 (3) ◽  
pp. 2157-2164 ◽  
Author(s):  
Jingzhen Yuan ◽  
Lee Slice ◽  
John H. Walsh ◽  
Enrique Rozengurt
Keyword(s):  
Protein Kinase ◽  
G Protein ◽  
Protein Kinase D ◽  
Heterotrimeric G Protein ◽  
Α Subunit

The heterotrimeric G‐protein beta subunit Gpb1 controls hyphal growth under low oxygen conditions through the protein kinase A pathway and is essential for virulence in the fungus Mucor circinelloides

2020 ◽  
Vol 22 (10) ◽  
Author(s):  
Marco Iván Valle‐Maldonado ◽  
José Alberto Patiño‐Medina ◽  
Carlos Pérez‐Arques ◽  
Nancy Yadira Reyes‐Mares ◽  
Irvin Eduardo Jácome‐Galarza ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
G Protein ◽  
Hyphal Growth ◽  
Mucor Circinelloides ◽  
Beta Subunit ◽  
Low Oxygen ◽  
Heterotrimeric G Protein ◽  
Oxygen Conditions ◽  
Kinase A

scholarly journals A Sphingolipid Elicitor-Inducible Mitogen-Activated Protein Kinase Is Regulated by the Small GTPase OsRac1 and Heterotrimeric G-Protein in Rice

2005 ◽  
Vol 138 (3) ◽  
pp. 1644-1652 ◽  
Author(s):  
Damien Lieberherr ◽  
Nguyen Phuong Thao ◽  
Ayako Nakashima ◽  
Kenji Umemura ◽  
Tsutomu Kawasaki ◽  
...  
Keyword(s):  
Protein Kinase ◽  
G Protein ◽  
Small Gtpase ◽  
Mitogen Activated Protein Kinase ◽  
Heterotrimeric G Protein ◽  
Mitogen Activated Protein

scholarly journals G-Protein-coupled Receptors and Fcγ-receptors Mediate Activation of Akt/Protein Kinase B in Human Phagocytes

1997 ◽  
Vol 272 (44) ◽  
pp. 28096-28101 ◽  
Author(s):  
Bettina Tilton ◽  
Mirjana Andjelkovic ◽  
Svetlana A. Didichenko ◽  
Brian A. Hemmings ◽  
Marcus Thelen
Keyword(s):  
Protein Kinase ◽  
G Protein ◽  
Protein Kinase B ◽  
G Protein Coupled Receptors ◽  
Fcγ Receptors ◽  
G Protein Coupled

scholarly journals High expression of G-protein signaling modulator 2 in hepatocellular carcinoma facilitates tumor growth and metastasis by activating the PI3K/AKT signaling pathway

Tumor Biology ◽  
2017 ◽  
Vol 39 (3) ◽  
pp. 101042831769597 ◽  
Author(s):  
Xiao-Qin He ◽  
Yue-Feng Zhang ◽  
Jia-Jun Yu ◽  
Yuan-Yuan Gan ◽  
Na-Na Han ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Protein Kinase ◽  
Hepatitis B ◽  
G Protein ◽  
Protein Kinase B ◽  
G Protein Signaling ◽  
Protein Signaling ◽  
Cyclin Dependent Kinase ◽  
B Virus

The aim of this study was to investigate the role of G-protein signaling modulator 2 in the carcinogenesis and progression of hepatocellular carcinoma. We previously showed that G-protein signaling modulator 2 was upregulated in hepatitis B virus-related hepatocellular carcinoma tissues through a hierarchical clustering analysis. With this study, we first assessed the expression pattern of G-protein signaling modulator 2 in hepatocellular carcinoma specimens and adjacent noncancerous tissues; clinical data were analyzed, along survival times, utilizing the Kaplan–Meier method. Moreover, the functions of G-protein signaling modulator 2 were examined using small-interfering RNAs in vitro. The results showed that G-protein signaling modulator 2 was clearly overexpressed in hepatocellular carcinoma tissues and cell lines and that the G-protein signaling modulator 2 expression level was related to tumor size and hepatitis B virus infection. Furthermore, G-protein signaling modulator 2 knockdown studies suggested that G-protein signaling modulator 2 accelerates cell growth, cell cycle, migration, and invasion and inhibits apoptosis, acting as an oncogene in hepatocellular carcinoma. Western blotting indicated that silencing of G-protein signaling modulator 2 in HepG2 and SMMC-7721 cells increased the expression levels of Bax, caspase-3, and E-cadherin, while notably suppressing the cyclin-dependent kinase 4, cyclin-dependent kinase 6, CyclinD1, Snail1, Vimentin, and matrix metallopeptidase 9 expression levels, compared with that in the control groups. In addition, we found that G-protein signaling modulator 2 can affect the expression of key proteins involved in protein kinase B activation. In conclusion, high expression of G-protein signaling modulator 2 was involved in the pathological processes of hepatocellular carcinoma through activation of the phosphatidylinositol 3-kinase/protein kinase B signaling pathway, which may provide an attractive potential diagnostic biomarker and therapeutic target for treatment of hepatocellular carcinoma.

scholarly journals Interplay between the heterotrimeric G-protein subunits Gαq and Gαi2 sets the threshold for chemotaxis and TCR activation

2009 ◽  
Vol 10 (1) ◽  
pp. 27 ◽  
Author(s):  
Jacob Ngai ◽  
Marit Inngjerdingen ◽  
Torunn Berge ◽  
Kjetil Taskén
Keyword(s):  
G Protein ◽  
Heterotrimeric G Protein ◽  
Protein Subunits ◽  
Tcr Activation
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