scholarly journals Identification of a Functional Peroxisome Proliferator-responsive Element in the Murine Fatty Acid Transport Protein Gene

1999 ◽  
Vol 274 (7) ◽  
pp. 3970-3977 ◽  
Author(s):  
Brigitte I. Frohnert ◽  
To Y. Hui ◽  
David A. Bernlohr
Keyword(s):  
Fatty Acid ◽  
Protein Gene ◽  
Transport Protein ◽  
Fatty Acid Transport ◽  
Peroxisome Proliferator ◽  
Acid Transport ◽  
Fatty Acid Transport Protein ◽  
Responsive Element

scholarly journals Characterization of the Murine Fatty Acid Transport Protein Gene and Its Insulin Response Sequence

1998 ◽  
Vol 273 (42) ◽  
pp. 27420-27429 ◽  
Author(s):  
To Y. Hui ◽  
Brigitte I. Frohnert ◽  
Anne Johnston Smith ◽  
Jean E. Schaffer ◽  
David A. Bernlohr
Keyword(s):  
Fatty Acid ◽  
Protein Gene ◽  
Insulin Response ◽  
Transport Protein ◽  
Response Sequence ◽  
Fatty Acid Transport ◽  
Acid Transport ◽  
Fatty Acid Transport Protein

scholarly journals Endogenous Peroxisome Proliferator-Activated Receptor-γ Augments Fatty Acid Uptake in Oxidative Muscle

Endocrinology ◽  
2008 ◽  
Vol 149 (11) ◽  
pp. 5374-5383 ◽  
Author(s):  
Andrew W. Norris ◽  
Michael F. Hirshman ◽  
Jianrong Yao ◽  
Niels Jessen ◽  
Nicolas Musi ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Uptake ◽  
Transport Protein ◽  
Fatty Acid Transport ◽  
Peroxisome Proliferator ◽  
Acid Uptake ◽  
Acid Transport ◽  
Peroxisome Proliferator Activated Receptor ◽  
Nonesterified Fatty Acids ◽  
Fatty Acid Transport Protein

In the setting of insulin resistance, agonists of peroxisome proliferator-activated receptor (PPAR)-γ restore insulin action in muscle and promote lipid redistribution. Mice with muscle-specific knockout of PPARγ (MuPPARγKO) develop excess adiposity, despite reduced food intake and normal glucose disposal in muscle. To understand the relation between muscle PPARγ and lipid accumulation, we studied the fuel energetics of MuPPARγKO mice. Compared with controls, MuPPARγKO mice exhibited significantly increased ambulatory activity, muscle mitochondrial uncoupling, and respiratory quotient. Fitting with this latter finding, MuPPARγKO animals compared with control siblings exhibited a 25% reduction in the uptake of the fatty acid tracer 2-bromo-palmitate (P < 0.05) and a 13% increase in serum nonesterified fatty acids (P = 0.05). These abnormalities were associated with no change in AMP kinase (AMPK) phosphorylation, AMPK activity, or phosphorylation of acetyl-CoA carboxylase in muscle and occurred despite increased expression of fatty acid transport protein 1. Palmitate oxidation was not significantly altered in MuPPARγKO mice despite the increased expression of several genes promoting lipid oxidation. These data demonstrate that PPARγ, even in the absence of exogenous activators, is required for normal rates of fatty acid uptake in oxidative skeletal muscle via mechanisms independent of AMPK and fatty acid transport protein 1. Thus, when PPARγ activity in muscle is absent or reduced, there will be decreased fatty acid disposal leading to diminished energy utilization and ultimately adiposity.

Intestinal deletion of fatty acid transport protein 4 in mice increases blood chylomicrons

2020 ◽  
Author(s):  
W Chamulitrat ◽  
J Seeßle ◽  
B Javaheri-Haghighi ◽  
S Döring ◽  
X Zhu ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Transport Protein ◽  
Fatty Acid Transport ◽  
Acid Transport ◽  
Fatty Acid Transport Protein

scholarly journals 11β-Hydroxysteroid dehydrogenase-1 is involved in bile acid homeostasis by modulating fatty acid transport protein-5 in the liver of mice

2014 ◽  
Vol 3 (5) ◽  
pp. 554-564 ◽  
Author(s):  
Carlos A. Penno ◽  
Stuart A. Morgan ◽  
Adam J. Rose ◽  
Stephan Herzig ◽  
Gareth G. Lavery ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Bile Acid ◽  
Hydroxysteroid Dehydrogenase ◽  
Transport Protein ◽  
Fatty Acid Transport ◽  
Acid Transport ◽  
Fatty Acid Transport Protein

Effects of fatty acid transport protein 1 on proliferation and differentiation of porcine intramuscular preadipocytes

2016 ◽  
Vol 88 (5) ◽  
pp. 731-738
Author(s):  
Xiaoling Chen ◽  
Yanliu Luo ◽  
Ruisheng Wang ◽  
Bo Zhou ◽  
Zhiqing Huang ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Transport Protein ◽  
Fatty Acid Transport ◽  
Acid Transport ◽  
Fatty Acid Transport Protein ◽  
Proliferation And Differentiation
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