scholarly journals Identification of a negative regulatory element involved in tissue-specific expression of mouse renin genes.

1992 ◽  
Vol 89 (3) ◽  
pp. 885-889 ◽  
Author(s):  
G. Barrett ◽  
M. Horiuchi ◽  
M. Paul ◽  
R. E. Pratt ◽  
N. Nakamura ◽  
...  
Keyword(s):  
Regulatory Element ◽  
Specific Expression ◽  
Negative Regulatory Element ◽  
Tissue Specific ◽  
Tissue Specific Expression

scholarly journals Identification of an Intronic Regulatory Element Necessary for Tissue-Specific Expression of Foxn1 in Thymic Epithelial Cells

2019 ◽  
Vol 203 (3) ◽  
pp. 686-695 ◽  
Author(s):  
Brian M. Larsen ◽  
Jennifer E. Cowan ◽  
Yueqiang Wang ◽  
Yu Tanaka ◽  
Yongge Zhao ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Regulatory Element ◽  
Thymic Epithelial Cells ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression

scholarly journals A compact, in vivo screen of all 6-mers reveals drivers of tissue-specific expression and guides synthetic regulatory element design

2013 ◽  
Vol 14 (7) ◽  
pp. R72 ◽  
Author(s):  
Robin P Smith ◽  
Samantha J Riesenfeld ◽  
Alisha K Holloway ◽  
Qiang Li ◽  
Karl K Murphy ◽  
...  
Keyword(s):  
Regulatory Element ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression ◽  
In Vivo Screen

Cross-binding of factors to functionally different promoter elements in c-fos and skeletal actin genes

1989 ◽  
Vol 9 (5) ◽  
pp. 2191-2201
Author(s):  
K Walsh
Keyword(s):  
Serum Response Factor ◽  
Regulatory Element ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression ◽  
Actin Genes ◽  
Tata Element ◽  
Actin Promoter ◽  
Serum Response

A conserved 28-base-pair element in the skeletal actin promoter was sufficient to activate muscle-specific expression when placed upstream of a TATA element. This muscle regulatory element (MRE) is similar in structure to the serum response element (SRE), which is present in the promoters of the c-fos proto-oncogene and the nonmuscle actin genes. The SRE can function as a constitutive promoter element. Though the MRE and SRE differed in their tissue-specific expression properties, both elements bound to the same protein factors in vitro. These proteins are the serum response factor (SRF) and the muscle actin promoter factors 1 and 2 (MAPF1 and MAPF2). The SRF and MAPF proteins were resolved by chromatographic procedures, and they differed in their relative affinities for each element. The factors were further distinguished by their distinct, but overlapping, methylation interference footprint patterns on each element. These data indicate that the differences in tissue-specific expression may be due to a complex interaction of protein factors with these sequences.

scholarly journals Cross-binding of factors to functionally different promoter elements in c-fos and skeletal actin genes.

1989 ◽  
Vol 9 (5) ◽  
pp. 2191-2201 ◽  
Author(s):  
K Walsh
Keyword(s):  
Serum Response Factor ◽  
Regulatory Element ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression ◽  
Actin Genes ◽  
Tata Element ◽  
Actin Promoter ◽  
Serum Response

A conserved 28-base-pair element in the skeletal actin promoter was sufficient to activate muscle-specific expression when placed upstream of a TATA element. This muscle regulatory element (MRE) is similar in structure to the serum response element (SRE), which is present in the promoters of the c-fos proto-oncogene and the nonmuscle actin genes. The SRE can function as a constitutive promoter element. Though the MRE and SRE differed in their tissue-specific expression properties, both elements bound to the same protein factors in vitro. These proteins are the serum response factor (SRF) and the muscle actin promoter factors 1 and 2 (MAPF1 and MAPF2). The SRF and MAPF proteins were resolved by chromatographic procedures, and they differed in their relative affinities for each element. The factors were further distinguished by their distinct, but overlapping, methylation interference footprint patterns on each element. These data indicate that the differences in tissue-specific expression may be due to a complex interaction of protein factors with these sequences.

Tissue-specific expression patterns of nuclear receptors

2013 ◽  
Author(s):  
AL Bookout ◽  
Y Jeong ◽  
M Downes ◽  
RT Yu ◽  
RM Evans ◽  
...  
Keyword(s):  
Nuclear Receptors ◽  
Expression Patterns ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression
Sign in / Sign up

Export Citation Format

Share Document