scholarly journals Incorporation of a single His residue by rational design enables thiol-ester hydrolysis by human glutathione transferase A1-1

2004 ◽  
Vol 101 (36) ◽  
pp. 13163-13167 ◽  
Author(s):  
S. Hederos ◽  
K. S. Broo ◽  
E. Jakobsson ◽  
G. J. Kleywegt ◽  
B. Mannervik ◽  
...  
Keyword(s):  
Rational Design ◽  
Glutathione Transferase ◽  
Ester Hydrolysis ◽  
Thiol Ester

scholarly journals Rational Design of an Organometallic Glutathione Transferase Inhibitor

2009 ◽  
Vol 48 (21) ◽  
pp. 3854-3857 ◽  
Author(s):  
Wee Han Ang ◽  
Lorien J. Parker ◽  
Anastasia De Luca ◽  
Lucienne Juillerat-Jeanneret ◽  
Craig J. Morton ◽  
...  
Keyword(s):  
Rational Design ◽  
Glutathione Transferase

Exploration of in vitro pro-drug activation and futile cycling by glutathione S-transferases: thiol ester hydrolysis and inhibitor maturation

2003 ◽  
Vol 414 (2) ◽  
pp. 303-311 ◽  
Author(s):  
Catherine Ibarra ◽  
Mark P Grillo ◽  
Mario Lo Bello ◽  
Marzia Nucettelli ◽  
Theo K Bammler ◽  
...  
Keyword(s):  
Ester Hydrolysis ◽  
Thiol Ester ◽  
Glutathione S Transferases ◽  
Futile Cycling ◽  
Drug Activation

scholarly journals Short Peptides in Minimalistic Biocatalyst Design

Biocatalysis ◽  
2015 ◽  
Vol 1 (1) ◽  
pp. 67-81 ◽  
Author(s):  
Krystyna L. Duncan ◽  
Rein V. Ulijn
Keyword(s):  
Active Sites ◽  
Rational Design ◽  
Similar Rate ◽  
Ester Hydrolysis ◽  
Peptide Sequence ◽  
Short Peptides ◽  
Significant Progress ◽  
Fundamental Understanding ◽  
Recent Developments ◽  
Binding Pockets

AbstractWe review recent developments in the use of short peptides in the design of minimalistic biocatalysts focusing on ester hydrolysis. A number of designed peptide nanostructures are shown to have (modest) catalytic activity. Five features are discussed and illustrated by literature examples, including primary peptide sequence, nanosurfaces/scaffolds, binding pockets, multivalency and the presence of metal ions. Some of these are derived from natural enzymes, but others, such as multivalency of active sites on designed nanofibers, may give rise to new features not found in natural enzymes. Remarkably, it is shown that each of these design features give rise to similar rate enhancements in ester hydrolysis. Overall, there has been significant progress in the development of fundamental understanding of the factors that influence binding and activity in recent years, holding promise for increasingly rational design of peptide based biocatalysts.

scholarly journals Rational Design of an Organometallic Glutathione Transferase Inhibitor

2009 ◽  
Vol 121 (21) ◽  
pp. 3912-3915 ◽  
Author(s):  
Wee Han Ang ◽  
Lorien J. Parker ◽  
Anastasia De Luca ◽  
Lucienne Juillerat-Jeanneret ◽  
Craig J. Morton ◽  
...  
Keyword(s):  
Rational Design ◽  
Glutathione Transferase

Thiol Ester Hydrolysis Catalyzed by GlutathioneS-Transferase A1-1†

Biochemistry ◽  
1998 ◽  
Vol 37 (42) ◽  
pp. 14948-14957 ◽  
Author(s):  
Eric C. Dietze ◽  
Mark P. Grillo ◽  
Thomas Kalhorn ◽  
Brenda S. Nieslanik ◽  
Claudia M. Jochheim ◽  
...  
Keyword(s):  
Ester Hydrolysis ◽  
Thiol Ester

The kinetics and mechanism of metal ion promoted thiol ester hydrolysis

1969 ◽  
Vol 10 (24) ◽  
pp. 1991-1994 ◽  
Author(s):  
D.P.N. Satchell ◽  
I.I. Secemski
Keyword(s):  
Metal Ion ◽  
Ester Hydrolysis ◽  
Kinetics And Mechanism ◽  
Thiol Ester

scholarly journals The Free Energy of Thiol Ester Hydrolysis

1960 ◽  
Vol 235 (12) ◽  
pp. 3608-3614 ◽  
Author(s):  
William P. Jencks ◽  
Shirley Cordes ◽  
Joan Carriuolo
Keyword(s):  
Free Energy ◽  
Ester Hydrolysis ◽  
Thiol Ester

Molecular insights on the dynamic stability of peptide nucleic acid functionalized carbon and boron nitride nanotubes

2021 ◽  
Vol 23 (1) ◽  
pp. 219-228
Author(s):  
Nabanita Saikia ◽  
Mohamed Taha ◽  
Ravindra Pandey
Keyword(s):  
Nucleic Acid ◽  
Boron Nitride ◽  
Nucleic Acids ◽  
Dynamic Stability ◽  
Peptide Nucleic Acid ◽  
Rational Design ◽  
Peptide Nucleic Acids ◽  
Boron Nitride Nanotubes ◽  
Molecular Hybrids ◽  
Single Wall Nanotubes

The rational design of self-assembled nanobio-molecular hybrids of peptide nucleic acids with single-wall nanotubes rely on understanding how biomolecules recognize and mediate intermolecular interactions with the nanomaterial's surface.

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