341. STUDY OF APHRODISIAC DRUG ACID PHOS ON MALE ALBINO RAT

2010 ◽  
Vol 22 (9) ◽  
pp. 141
Author(s):  
C. K. I. Deshmukh

The male albino rat, Rattus norvegicus maintained in the laboratory by supplying regularly food and water. Acid phos is a well known aphrodisiac drug from homeopathy medical system. Doses of 200 gm of 30 number globules made from sugar of milk and moistened by 15 mL of acid phos (H3PO3) of 6 potency. Group-I, II and III experimental rats were carried out for 15, 30, and 15 day recovery period respectively. Appreciable behavioral changes and changes in the body weights were noticed. In 15, 30 and in 15 days of recovery period, the acid phosphatase, SGOT and albumin were significant (P < 0.05) while alkaline phosphatase, SGPT, cholesterol, glucose, total proteins and globulin was found non-significant but A:G ratio was increasedsignificantly in 30 days of treatment. The weight of liver, kidney, and testis has found linear increased relationship with the body weight but significant (P < 0.050) increased in the weight of seminal vesicle and body weight in the experimental rat. Various histo-architectural changes were observed in the tissues of liver, kidney, testis and seminal vesicle. Both liver and kidney showed degenerative changes after 15 and 30 days .Tetraploid stages of liver pernchymal cells were predominant in the experimental rats while in 15 days of recovery period, both attained the recovery. In 30 days, the diameter of seminiferous tubules is markedly reduced, with thin unfolded mucosa. In 15 days of administration of acid phos, the intertubular spaces between the seminiferous tubule were also reduced. The number of spermatids was increased in recovery period, the testis showed the recovery. In 15 days of administration, the secretion in the lumen of seminal vesicles increased related with the structure of the epithelium of seminal vesicles while in 15 days of recovery period, the seminal vesicles showed recovery of secretory activities with pseudostratified epithelium. All the results are discussed detailed in paper.

2017 ◽  
Vol 35 (1) ◽  
pp. 49
Author(s):  
Naela Wanda Yusria Dalimunthe ◽  
Agung Budiyanto ◽  
Erna Prawita Setyowati ◽  
Agustina Dwi Wijayanti

Seminal vesicles were collected from 60 heads of Bulls which butchered in slaughter house (RPH) Yogyakarta. The aims of this study are knowing the relationship between body weight, age, fluids volume and concentration of prostaglandin F2 α (PGF2α) in seminal vesicle of beef cattle. Those seminal vesicles were gathered from bulls which recorded its body weight and age then measured its seminal vesicles for weight, fluids volume and PGF2α levels. The PGF2α level was measured by Enzyme-Linked Immunosorbent Assay. Statistical analysis was performed using one way – analysis of varian, regression and correlation with P<0.05. Body weight of bulls showed positive correlation with the weight of seminal vesicle and its fluids volume. However, PGF2α levels were not correlated with the body weight of cattle. Weight of seminal vesicles also exhibited positive correlation with volume of vesicle fluids but no correlation with PGF2α levels. Based on the age of bulls, there were no correlation withthe weight of seminal vesicles, seminal fluids volume and PGF2α levels. Those result indicated that the weight and fluids volume were affected by the body weight of bulls altough the PGF2α levels have a standard of developmentwhich seems affected by other factors such as concentration of androgen hormone.


2014 ◽  
Vol 84 (1-2) ◽  
pp. 5-11 ◽  
Author(s):  
Eun Y. Jung ◽  
Sung C. Jun ◽  
Un J. Chang ◽  
Hyung J. Suh

Previously, we have found that the addition of L-ascorbic acid to chitosan enhanced the reduction in body weight gain in guinea pigs fed a high-fat diet. We hypothesized that the addition of L-ascorbic acid to chitosan would accelerate the reduction of body weight in humans, similar to the animal model. Overweight subjects administered chitosan with or without L-ascorbic acid for 8 weeks, were assigned to three groups: Control group (N = 26, placebo, vehicle only), Chito group (N = 27, 3 g/day chitosan), and Chito-vita group (N = 27, 3 g/day chitosan plus 2 g/day L-ascorbic acid). The body weights and body mass index (BMI) of the Chito and Chito-vita groups decreased significantly (p < 0.05) compared to the Control group. The BMI of the Chito-vita group decreased significantly compared to the Chito group (Chito: -1.0 kg/m2 vs. Chito-vita: -1.6 kg/m2, p < 0.05). The results showed that the chitosan enhanced reduction of body weight and BMI was accentuated by the addition of L-ascorbic acid. The fat mass, percentage body fat, body circumference, and skinfold thickness in the Chito and Chito-vita groups decreased more than the Control group; however, these parameters were not significantly different between the three groups. Chitosan combined with L-ascorbic acid may be useful for controlling body weight.


2020 ◽  
Vol 20 (8) ◽  
pp. 1262-1267
Author(s):  
Haojun Yang ◽  
Hanyang Liu ◽  
YuWen Jiao ◽  
Jun Qian

Background: G protein-coupled bile acid receptor (TGR5) is involved in a number of metabolic diseases. The aim of this study was to identify the role of TGR5 after Roux-en-Y gastric bypass (GBP). Methods: Wild type and TGR5 knockout mice (tgr5-/-) were fed a high-fat diet (HFD) to establish the obesity model. GBP was performed. The changes in body weight and food intake were measured. The levels of TGR5 and peptide YY (PYY) were evaluated by RT-PCR, Western blot, and ELISA. Moreover, the L-cells were separated from wild type and tgr5-/- mice. The levels of PYY in L-cells were evaluated by ELISA. Results: The body weights were significantly decreased after GBP in wild type mice (p<0.05), but not tgr5-/- mice (p>0.05). Food intake was reduced after GBP in wild type mice, but also not significantly affected in tgr5-/- mice (p>0.05). The levels of PYY were significantly increased after GBP compared with the sham group (p<0.05); however, in tgr5-/- mice the expression of PYY was not significantly affected (p>0.05). After INT-777 stimulation in L-cells obtained from murine intestines, the levels of PYY were significantly increased in L-cells tgr5+/+ (p<0.05). Conclusion: Our study suggests that GBP up-regulated the expression of TGR5 in murine intestines, and increased the levels of PYY, which further reduced food intake and decreased the body weight.


1985 ◽  
Vol 249 (2) ◽  
pp. R159-R165 ◽  
Author(s):  
G. L. Florant ◽  
A. K. Lawrence ◽  
K. Williams ◽  
W. A. Bauman

Fasting plasma insulin (PI) and glucose (PG) concentrations were measured throughout the body weight cycle of marmots. Animals gained weight during summer, and in late fall body weight peaked, after which they ceased feeding. Each month euthermic animals were injected intra-arterially with either dextrose (500 mg/kg) or porcine insulin (0.1 U/kg), and blood samples were collected over the subsequent 2 h. During weight gain fasting PI concentration and pancreatic B-cell response to injected dextrose increased markedly. Maximal insulin release to a dextrose challenge was measured during peak body weight or when body weight initially began to decline. The PG concentration after exogenous insulin administration was slight (less than 10%) in the fall but increased approximately 25% in the spring after marmots lost weight. Basal PG levels were not significantly different throughout the year. Basal fasting PI concentrations were significantly higher during the fall (P less than 0.01). It is suggested that in the fall, when marmots are obese, hyperinsulinemia and peripheral insulin resistance appear. Furthermore, in two animals with an increase in body weight of approximately 30% or less over the summer, peripheral resistance was demonstrable, albeit not as marked as in animals that appropriately doubled their body weights when given food ad libitum. Thus we hypothesize that factors other than adiposity, i.e., food intake, central nervous system input to the pancreatic B-cell, and/or changes in B-cell sensitivity to PG, may contribute to the observed peripheral insulin resistance and may be involved in body weight regulation.


1972 ◽  
Vol 27 (2) ◽  
pp. 305-312 ◽  
Author(s):  
Sharad V. Apte ◽  
Leela Iyengar

1. The body composition was determined of forty-one fetuses of different gestational ages born to mothers belonging to a low socio-economic group of the population.2. With increasing gestational age the water content fell from 88% at 28 weeks to 76% at term; the fat content increased from 2.1% to 11.2% and the protein content increased from 6.9 to 9.3%.3. The changes in body composition were more closely related to body-weight than to gestational age.4. The calcium, Phosphorus and magnesium contents of the body per unit fat-free weight progressively increased with gestational age, and at term the values appeared to be considerably lower than those reported in the literature. The Ca:P ratio was constant at different body-weights.5. The body iron content per unit of fat-free weight increased marginally with increasing gestational age. The value was almost 30% lower than the values reported from elsewhere.6. It is suggested that chemical composition and nutrient stores of the developing foetus can be considerably influenced by the state of maternal nutrition.


1957 ◽  
Vol 188 (3) ◽  
pp. 435-438 ◽  
Author(s):  
M. J. Fregly ◽  
N. B. Marshall ◽  
J. Mayer

Goldthioglucose-obese mice cannot adjust their food intake to meet the increased energy requirements due to cold. At all ambient temperatures above 15°C the spontaneous running activity of these animals is less than that observed for nonobese controls. Activity of obese mice is maximal at 19°C and minimal at 15°C or lower. Body weights decrease during exposure to cold. In contrast to that of obese mice, running activity of nonobese controls is maximal at an ambient temperature of 25°C but nearly ceases at 15°C or lower. The food intake of these animals increases in the cold and remains elevated even at temperatures at which activity decreases. The body weight of nonobese controls is either maintained constant or increases during exposure to cold air.


1980 ◽  
Vol 30 (1) ◽  
pp. 153-156 ◽  
Author(s):  
J. P. Mittal ◽  
P. K. Ghosh

ABSTRACTSeasonal fluctuations in oestrous activity and live weight were studied in ewes of the Marwari breed indigenous to the Rajasthan Desert in north-western India. Of the ewes examined 80 to 100% were in oestrus every month of the year, indicating thereby the non-seasonality of female reproductive activity in this breed. On average, each ewe exhibited heat 18 times a year. The incidence of silent heats was low (4·2 %). The average length of an oestrous cycle was 17 days, while the actual period of oestrus varied from 24 to 48 h with an average of 36 h. No seasonal effect on these activities could be observed. The maximum and minimum body weights of the animals were recorded during the autumn (October) and summer (June) months respectively. The body weights differed significantly (P<0·05) between months. Sexual activity in these animals is, therefore, apparently not affected by changes in body weight. The continuous nature of oestrous activity in Marwari sheep may be economically exploited by regulating the lambing season according o t the prevailing ecological conditions and market demands, without the use of hormones.


Author(s):  
Laksmi Wulandari ◽  
Gatot Soegiarto ◽  
Anna Febriani ◽  
Farah Fatmawati ◽  
Wirya Sastra Amran

Abstract Introduction There are a substantial number of lung cancer patients with negative mutations in Indonesia. This type of cancer is deemed to be the major contributor of lung cancer patient’s death. However, reseaerch related to therapy using vinorelbine combined with platinum-based compounds is still scarce in Indonesia. The aim of this study was to compare the efficacy and tolerability between vinorelbine and carboplatin with vinorelbin and cisplatin in stage III-IV epidermal growth factor receptor (EGFR) mutations-negative non-small cell lung cancer (NSCLC). Methods The participants were divided into two groups—group I(vinorelbine–carboplatin) and group II (vinorelbine–cisplatin). The participants were assessed based on several measurement criteria. Not only Eq-5D was performed, but the body weight and response evaluation criteria for solid tumors (RECIST) were also examined. The participants received chemotherapy for four cycles (1 cycle = 21 days). Results The quality of life was considered stable in 60% of group I and 60% of group II (p=0.255). In both groups, 46.67% of participants had an increased body weight, while the other 20.00% was stable (p = 1.000). In terms of RECIST evaluation after the second cycle, 80.00% of group I and 86.67% of group II were considered to have a stable disease, with 20% of group I and none of group II had partial response (p = 0.027). However, after the fourth cycle, there were no significant difference between the groups (p = 0.734). Conclusion In EGFR mutation-negative NSCLC patients, the combination of vinorelbine and carboplatin showed comparable outcomes to vinorelbine and cisplatin chemotherapy with no significant differences.


2021 ◽  
Vol 888 (1) ◽  
pp. 012012
Author(s):  
H D Putranto ◽  
Nurmeiliasari ◽  
Y Yumiati ◽  
A M Nur

Abstract Local chickens in developing countries, including Indonesia, have great potential to be developed into natural superior breeds to support food security and improve farmer welfare. Meanwhile, the major endemic subspecies found in the Bengkulu province are burgo and kampung chicken, as well as ketarras which are recently bred intensively. Therefore, this study aims to analyze the disparities in the morphometrics of three subspecies of local male chickens specifically on the body weight, length, chest girth and length, as well as wing span. Based on the results, the male burgo chicken morphometrical size was significantly smaller than ketarras, while the ketarras chicken was significantly smaller than kampung (P < 0.05). Furthermore, the average body weights for the burgo, ketarras and kampung chicken were 1.0, 1.2 and 1.9 kg cock-1, respectively, while the average of body length, chest and chest length, as well as wing span were 29.9, 40.0, 47.7 cm cock-1; 26.2, 30.1, 36.3 cm cock-1; 12.6, 17.8, 20.3 cm cock-1, and 34.4, 41.9, 55.9 cm cock-1, respectively. Therefore, it was concluded that the burgo and kampung chicken have the smallest and biggest morphometric sizes respectively.


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