scholarly journals 208.Zona pellucida vaccines for fertility control of brushtail possums in New Zealand

2004 ◽  
Vol 16 (9) ◽  
pp. 208
Author(s):  
J. A. Duckworth ◽  
X. Cui ◽  
F. C. Molinia ◽  
W. Lubitz ◽  
P. E. Cowan
Keyword(s):  
New Zealand ◽  
Immune Responses ◽  
Zona Pellucida ◽  
Animal Health ◽  
Peptide Identification ◽  
Fertility Control ◽  
Early Embryo ◽  
Health Board ◽  
Ongoing Research ◽  
Contraceptive Vaccine

Introduced marsupial brushtail possums (Trichosurus vulpecula) are a major pest in New Zealand because of their impacts on conservation values and agricultural production. Immunologically-based fertility control (immunocontraception) offers an effective and humane alternative approach to possum management. The zona pellucida (ZP) is an extracellular coat around all mammalian eggs and an attractive target for the development of immunocontraceptive vaccines. Antibodies against ZP are ovary-specific and act by preventing sperm from binding and penetrating the ova and/or by disrupting the development of follicles or early embryo. The aim of these studies was to test the efficacy of possum-derived ZP antigens for their ability to elicit sustained immune responses and cause infertility, and to assess a range of options for development of a bait-delivered contraceptive vaccine. Alloimmunisation with possum ZP2 and ZP3 proteins showed that self-ZP antigens elicited strong humoral immune responses and reduced the fertility of female possums by 72-80%. Several potentially possum-specific immunocontraceptive peptides have been identified by linear epitope mapping and amino acid alignment and are being tested for their ability to reduce fertility. Recent trials have demonstrated that possums mount immune responses against ZP antigens delivered in transgenic plants and bacterial ghosts. Research on antigen and specific peptide identification, non-target effects and delivery systems is ongoing. Research supported by NZ Foundation for�Research Science & Technology, Marsupial CRC and NZ Animal Health Board.

Porcine zonae pellucidae immunisation of tammar wallabies (Macropus eugenii): fertility and immune responses

2002 ◽  
Vol 14 (4) ◽  
pp. 215 ◽  
Author(s):  
A. L. Kitchener ◽  
L. M. Edds ◽  
F. C. Molinia ◽  
D. J. Kay
Keyword(s):  
Immune Responses ◽  
Zona Pellucida ◽  
Artificial Insemination ◽  
Reproductive Tract ◽  
Antral Follicles ◽  
Macropus Eugenii ◽  
Fertility Reduction ◽  
Contraceptive Vaccine ◽  
Mating Trial ◽  
Natural Mating

This study looked at the feasibility of targeting the zona pellucida for a contraceptive vaccine as a possible alternative method of control for overabundant macropods. Tammar wallabies, as a model for other macropods, were immunized with porcine zonae pellucidae (PZP) and were found to achieve significant concentrations of antibody to PZP in sera and reproductive tract fluids. Wallabies immunized with PZP exhibited lower ovarian weight with reduced numbers of antral follicles when compared with control animals. Wallabies were placed in a natural mating trial followed by an artificial insemination trial. None of the PZP-immunized wallabies produced offspring in the natural mating trial compared with 67% of control animals. To further assess fertility, a sub-sample of the wallabies were superovulated and artificially inseminated. This resulted in all control wallabies producing fertilized ova and all PZP-immunized wallabies failing to ovulate. These results suggest that immunocontraception based on targeting antigens of the zona pellucida may be an effective strategy for fertility reduction in macropods.

Differences between antigenic determinants of pig and cat zona pellucida proteins

Reproduction ◽  
2000 ◽  
pp. 15-23 ◽  
Author(s):  
K Jewgenow ◽  
M Rohleder ◽  
I Wegner
Keyword(s):  
In Vitro Fertilization ◽  
Zona Pellucida ◽  
Antigenic Determinants ◽  
Vitro Fertilization ◽  
Contraceptive Vaccine ◽  
Sperm Binding ◽  
Dependent Inhibition ◽  
Dose Dependent Inhibition ◽  
Dose Dependent

Despite many efforts, the control of reproduction in feral cat populations is still a problem in urban regions around the world. Immunocontraception is a promising approach; thus the present study examined the suitability of the widely used pig zona pellucida proteins (pZP) for contraception in feral domestic cats. Purified zona pellucida proteins obtained from pig and cat ovaries were used to produce highly specific antisera in rabbits. Antibodies against pZP raised in rabbits or lions were not effective inhibitors of either in vitro sperm binding (cat spermatozoa to cat oocytes) or in vitro fertilization in cats, whereas antibodies against feline zona pellucida proteins (fZP) raised in rabbits showed a dose-dependent inhibition of in vitro fertilization. Immunoelectrophoresis, ELISA and immunohistology of ovaries confirmed these results, showing crossreactivity of anti-fZP sera to fZP and to a lesser extent to pZP, but no interaction of anti-pZP sera with fZP. It is concluded that cat and pig zonae pellucidae express a very small number of shared antigenic determinants, making the use of pZP vaccine in cats questionable. A contraceptive vaccine based on feline zona pellucida determinants will be a better choice for the control of reproduction in feral cats if immunogenity can be achieved.

Registered nurse prescribing: A descriptive survey of prescribing practices in a single district health board in Aotearoa New Zealand

2020 ◽  
Vol 36 (3) ◽  
pp. 61-72
Author(s):  
Melinda McGinty ◽  
◽  
Betty Poot ◽  
Jane Clarke ◽  
◽  
...  
Keyword(s):  
Primary Care ◽  
New Zealand ◽  
Registered Nurse ◽  
Health Conditions ◽  
Health Board ◽  
Prescribing Practices ◽  
District Health ◽  
Survey Tool ◽  
Aotearoa New Zealand ◽  
Descriptive Survey

The expansion of prescribing rights in Aotearoa New Zealand has enabled registered nurse prescribers (RN prescribers) working in primary care and specialty teams, to enhance nursing care, by prescribing medicines to their patient population. This widening of prescribing rights was to improve the population’s access to medicines and health care; however, little is known about the medications prescribed by RN prescribers. This paper reports on a descriptive survey of self-reported RN prescribers prescribing in a single district health board. The survey tool used was a Microsoft Excel spreadsheet to record nurse’s area of practice, patient demographic details, health conditions seen, and medicines prescribed and deprescribed. Simple data descriptions and tabulations were used to report the data. Eleven RN prescribers consented to take part in the survey and these nurses worked in speciality areas of cardiology, respiratory, diabetes, and primary care. Findings from the survey demonstrated that RN prescribers prescribe medicines within their area of practice and within the limits of the list of medicines for RN prescribers. Those working in primary care saw a wider range of health conditions and therefore prescribed a broader range of medications. This survey revealed that the list of medications available for RN prescribers needs to be updated regularly to align with the release of evidence-based medications on the New Zealand Pharmaceutical Schedule. It is also a useful record for both educational and clinical settings of the types of medications prescribed by RN prescribers.

scholarly journals Modeling the Costs of Hospital-Acquired Infections in New Zealand

2003 ◽  
Vol 24 (3) ◽  
pp. 214-223 ◽  
Author(s):  
Nicholas Graves ◽  
Tanya M. Nicholls ◽  
Arthur J. Morris
Keyword(s):  
New Zealand ◽  
Economic Cost ◽  
Cost Effective ◽  
Sensitivity Analyses ◽  
Primary Data ◽  
Health Board ◽  
District Health ◽  
Hospital Acquired Infections ◽  
Input Variables ◽  
Hospital Acquired

AbstractObjective:To model the economic costs of hospital-acquired infections (HAIs) in New Zealand, by type of HAI.Design:Monte Carlo simulation model.Setting:Auckland District Health Board Hospitals (DHBH), the largest publicly funded hospital group in New Zealand supplying secondary and tertiary services. Costs are also estimated for predicted HAIs in admissions to all hospitals in New Zealand.Patients:All adults admitted to general medical and general surgical services.Method:Data on the number of cases of HAI were combined with data on the estimated prolongation of hospital stay due to HAI to produce an estimate of the number of bed days attributable to HAI. A cost per bed day value was applied to provide an estimate of the economic cost. Costs were estimated for predicted infections of the urinary tract, surgical wounds, the lower and upper respiratory tracts, the bloodstream, and other sites, and for cases of multiple sites of infection. Sensitivity analyses were undertaken for input variables.Results:The estimated costs of predicted HAIs in medical and surgical admissions to Auckland DHBH were $10.12 (US $4.56) million and $8.64 (US $3.90) million, respectively. They were $51.35 (US $23.16) million and $85.26 (US $38.47) million, respectively, for medical and surgical admissions to all hospitals in New Zealand.Conclusions:The method used produces results that are less precise than those of a specifically designed study using primary data collection, but has been applied at a lower cost. The estimated cost of HAIs is substantial, but only a proportion of infections can be avoided. Further work is required to identify the most cost-effective strategies for the prevention of HAI.

Should immunocontraception be used for wildlife population management?

2004 ◽  
Vol 26 (1) ◽  
pp. 61 ◽  
Author(s):  
DW Cooper
Keyword(s):  
Immune Response ◽  
New Zealand ◽  
Immune Responses ◽  
Fundamental Problem ◽  
Public Perceptions ◽  
Published Data ◽  
Red Foxes ◽  
European Rabbits ◽  
Selection For ◽  
Self Antigens

Immunocontraception involves eliciting an immune response against eggs, sperm or hormones so that successful reproduction is prevented. Work in Australasia is aimed at European rabbits (Oryctolagus cuniculus), red foxes (Vulpes vulpes), house mice (Mus musculus), common brushtail possums (Trichosurus vulpecula), koalas (Phascolartcos cinereus) and kangaroos (Macropus spp.), with the vaccines involved all containing self antigens or their relatives. Two fundamental problems have been inadequately addressed in this research. The first problem is that it is difficult to obtain strong immune responses against self antigens and so the vaccines may be ineffective. Most published data on the effect of immunocontraceptives on reproduction involve the use of an adjuvant of which there are many kinds. The materials enhance the immune response greatly. The most frequently used is Freund?s adjuvant which can cause chronic suffering. Its use on wildlife will lead to very negative public perceptions. There has been no convincing demonstration that successful immunocontraception is possible with any method of vaccination likely to be used in the field, if success is defined as contraception of a proportion of the population high enough for management requirements. If it is assumed that success can be achieved, the second fundamental problem arises with two potential consequences. Even with adjuvant, a substantial minority of the vaccinated animals remains fertile. The first consequence is that since failure to be contracepted is likely to be in part genetic, there is likely to be rapid selection for these non-responders. The method will become ineffective in a few generations. The second problem is that the offspring of the animals which breed will have altered immune responses. Their capacities to respond to their own pathogens or to harbor pathogens of other species in the same ecosystem are likely to be changed. The presence of chlamydia in P. cinereus and bovine tuberculosis in New Zealand T. vulpecula means that responses to these pathogens would have to be studied in offspring of immunocontracepted parents to ensure that the offspring were not more susceptible to them. New Zealand intentions to put an immunocontraceptive into a T. vulpecula gut worm must be viewed with caution by Australia. The eggs of transgenic worms will be easily transplanted either accidentally or deliberately back into Australia, and so infect T. vulpecula in Australia.

scholarly journals Chemical residue trends for Australian and New Zealand wool

2022 ◽  
Vol 12 (1) ◽  
Author(s):  
Stephen Ranford ◽  
Paul Swan ◽  
Chikako van Koten
Keyword(s):  
European Union ◽  
New Zealand ◽  
Animal Health ◽  
Synthetic Pyrethroid ◽  
Wool Fibre ◽  
Regulatory Change ◽  
Insect Growth Regulators ◽  
Insect Growth ◽  
Technology Improvement ◽  
Chemical Residue

AbstractTextile consumer trends towards improved product safety and high environmental standards have significantly influenced regulators in key consumer markets. The apparel wool industry sector has responded to regulators, and for three decades the Australia and New Zealand wool industries have managed advancements in ectoparasiticides and improved sheep treatments targeting high environmental, animal health and welfare standards leading to safe wool products. Australian and New Zealand chemical residue data from greasy wool have been consolidated and analysed for organophosphate, synthetic pyrethroid, insect growth regulator, neonicotinoid, macrocyclic lactone and spinosad active. Trend analysis has been applied to time domain data to evaluate advancements in ectoparasiticide technology after revising environmental, animal health and welfare standards. Analysis shows impacts from technology improvement, regulatory change and compliance by sheep farmers meeting or exceeding published European Union residue limits for regulated ectoparasiticides namely organochlorine, organophosphate, synthetic pyrethroid and insect growth regulators. Implications from advancements in ectoparasiticide technology, industry management and regulatory measures, include healthy sheep growing in clean pastoral environments with evidence of reduced wool residue levels which complement high and rising proportions of Australian and New Zealand wool fibre meeting European Union Ecolabel criteria.

scholarly journals Language in the Workplace Project and Workplace Communication for Skilled Migrants course at Victoria University of Wellington, New Zealand

2020 ◽  
Author(s):  
J de Bres ◽  
J Holmes ◽  
Angela Joe ◽  
Meredith Marra ◽  
Jonathan Newton ◽  
...  
Keyword(s):  
New Zealand ◽  
English Language ◽  
Applied Linguistics ◽  
Research Unit ◽  
Deaf Studies ◽  
Ongoing Research ◽  
Language Studies ◽  
Language Courses ◽  
Set Up ◽  
English Language Institute

The School of Linguistics and Applied Language Studies (LALS) at Victoria University of Wellington conducts research and teaching in Linguistics, Applied Linguistics, Writing and Deaf Studies. It incorporates a Deaf Studies Research Unit, which undertakes research on topics relating to deaf people and their language in New Zealand, and the New Zealand Dictionary Centre, set up in partnership with Oxford University Press, which provides a base for research into New Zealand lexicography and aspects of language in New Zealand. It also incorporates an English Language Institute, which specialises in teaching English language courses and teacher education programmes. A particular strength of the School's makeup is the opportunity to engage in research which benefits and is benefited by both theoretical and practical approaches to issues in linguistics and applied linguistics. This report describes one of a number of examples of the productive integration of language teaching and language research at LALS. We describe an ongoing research project that has developed organically over the past twelve years. The research involved first collecting and analysing authentic workplace interaction between native speakers, and then making use of it in explicit instruction aimed at developing socio-pragmatic proficiency in the workplace among skilled migrants with English as an Additional Language (EAL). We are now engaged in evaluating the results of the instruction, not only in the classroom, but also in workplaces where the migrants have been placed as interns.

scholarly journals Community Governance and Civil Society: An Examination of the Purpose, Intent and Structure of Residents' Groups in New Zealand

2021 ◽  
Author(s):  
◽  
Jarrod Coburn
Keyword(s):  
New Zealand ◽  
News Media ◽  
Local Community ◽  
Political Activity ◽  
Health Board ◽  
District Health ◽  
Community Governance ◽  
Set Up ◽  
Civil Defence ◽  
Charitable Activities

<p>Residents’ groups have been in existence in New Zealand for almost 150 years yet very little is known about them. The collection of residents’, ratepayers’ and progressive associations, community councils, neighbourhood committees and the like make up a part of the community governance sector that numbers over a thousand-strong. These groups are featured prominently in our news media, are active in local government affairs and expend many thousands of volunteer hours every year in their work in communities… but what exactly is that work? From the literature we see these groups can be a source of local community knowledge (Kass et al., 2009), a platform for political activity (Deegan, 2002), critical of government (Fullerton, 2005) or help maintain government transparency and accountability (Mcclymont and O'Hare, 2008). They are sometimes part of the establishment too (Wai, 2008) and are often heard promoting the interests of local people (Slater, 2004). Residents’ groups can be set up to represent the interests of a specific demographic group (Seng, 2007) or focus on protecting or promoting a sense of place (Kushner and Siegel, 2003) or physical environment (Savova, 2009). Some groups undertake charitable activities (Turkstra, 2008) or even act in a negative manner that can impact on the community (Horton, 1996). This research examines 582 New Zealand organisations to derive a set of purposes that residents’ groups perform and ascertains how their purposes differ between geo-social and political locality and over three distinct eras of community development. The thesis also examines the relationship between residents’ groups and councillors, council officers, district health board members and civil defence and seeks to uncover if the level of engagement (if any) has an affect on their overall raison d’etre. The research concludes with a typology of New Zealand residents’ groups along with the key purposes of each type.</p>

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