Genital ulcer disease in central Australia: predictors of testing and outcomes

Sexual Health ◽  
2006 ◽  
Vol 3 (2) ◽  
pp. 119 ◽  
Author(s):  
Janelle E. Wilkey ◽  
Katherine A. Fethers ◽  
Ahmed S. Latif ◽  
John M. Kaldor
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Infection ◽  
Herpes Simplex Virus Infection ◽  
Indigenous Communities ◽  
Genital Ulcer ◽  
Ulcer Disease ◽  
Genital Ulcer Disease ◽  
Central Australia ◽  
Simplex Virus

Objectives: To identify factors associated with the uptake and outcome of testing for infectious causes of genital ulcer disease (GUD) in central Australia. Methods: Prospective investigation of GUD cases in central Australia from February 2002 to August 2003. Data were collected from primary health care clinics in remote indigenous communities of Central Australia. Results: During the study period, 134 cases of GUD were reported and investigated. Of these cases, 71 (53%) were in women (age range 14–75, median 28) and 63 (47%) in men (14–63, median 28). Testing for syphilis was undertaken for 111 (82.8%) cases, 75 (56%) were tested for herpes simplex virus infection, and 82 (61.2%) for donovanosis. Testing for at least one of the three sexually transmissible pathogens of interest was undertaken in 128 (95.5%) cases, while 99 (73.9%) were tested for two pathogens and 41 (30.6%) for all three agents. Of subjects tested, 19.8% had new syphilis infection, 51% had herpes simplex virus infection and 7% had donovanosis. In 19 of 41 (46.3%) subjects fully investigated no cause for genital ulceration was found. Conclusion: This study provides the first quantitative description of GUD diagnosis in central Australia. Logistic constraints limited the systematic application of diagnostic tests. Current treatment protocols may need to be reassessed in light of the higher than expected detection of genital herpes as a cause of GUD.

scholarly journals The global and regional burden of genital ulcer disease due to herpes simplex virus: a natural history modelling study

2020 ◽  
Vol 5 (3) ◽  
pp. e001875 ◽  
Author(s):  
Katharine Jane Looker ◽  
Christine Johnston ◽  
Nicky J Welton ◽  
Charlotte James ◽  
Peter Vickerman ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Natural History ◽  
Genital Ulcer ◽  
Model Parameters ◽  
Global Burden ◽  
Ulcer Disease ◽  
Genital Ulcer Disease ◽  
Simplex Virus ◽  
Hsv 1

IntroductionHerpes simplex virus (HSV) infection can cause painful, recurrent genital ulcer disease (GUD), which can have a substantial impact on sexual and reproductive health. HSV-related GUD is most often due to HSV type 2 (HSV-2), but may also be due to genital HSV type 1 (HSV-1), which has less frequent recurrent episodes than HSV-2. The global burden of GUD has never been quantified. Here we present the first global and regional estimates of GUD due to HSV-1 and HSV-2 among women and men aged 15–49 years old.MethodsWe developed a natural history model reflecting the clinical course of GUD following HSV-2 and genital HSV-1 infection, informed by a literature search for data on model parameters. We considered both diagnosed and undiagnosed symptomatic infection. This model was then applied to existing infection estimates and population sizes for 2016. A sensitivity analysis was carried out varying the assumptions made.ResultsWe estimated that 187 million people aged 15–49 years had at least one episode of HSV-related GUD globally in 2016: 5.0% of the world’s population. Of these, 178 million (95% of those with HSV-related GUD) had HSV-2 compared with 9 million (5%) with HSV-1. GUD burden was highest in Africa, and approximately double in women compared with men. Altogether there were an estimated 8 billion person-days spent with HSV-related GUD globally in 2016, with 99% of days due to HSV-2. Taking into account parameter uncertainty, the percentage with at least one episode of HSV-related GUD ranged from 3.2% to 7.9% (120–296 million). However, the estimates were sensitive to the model assumptions.ConclusionOur study represents a first attempt to quantify the global burden of HSV-related GUD, which is large. New interventions such as HSV vaccines, antivirals or microbicides have the potential to improve the quality of life of millions of people worldwide.

scholarly journals Circumcision status and incident herpes simplex virus type 2 infection, genital ulcer disease, and HIV infection

AIDS ◽  
2012 ◽  
Vol 26 (9) ◽  
pp. 1141-1149 ◽  
Author(s):  
Supriya D. Mehta ◽  
Stephen Moses ◽  
Corette B. Parker ◽  
Kawango Agot ◽  
Ian Maclean ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Hiv Infection ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Genital Ulcer ◽  
Ulcer Disease ◽  
Genital Ulcer Disease ◽  
Simplex Virus

scholarly journals Herpes Simplex Virus (HSV) Infection in Men with Genital Ulcer Disease (GUD) - as Observed in Dhaka Medical College Hospital

2012 ◽  
Vol 22 (2) ◽  
pp. 55-61
Author(s):  
Shameem Al Mamun ◽  
M Abu Hena Chowdhury ◽  
Rashed Mohammad Khan ◽  
Md. Akram Ullah Sikder ◽  
M Mujibul Hoque
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Genital Herpes ◽  
Clinical Sign ◽  
Genital Ulcer ◽  
Ulcer Disease ◽  
Genital Ulcer Disease ◽  
Microbial Etiology ◽  
Simplex Virus

Genital herpes clinically underestimated because symptoms or sign occur only in some infection detected serologically. Prevalence of HSV subtypes in microbial etiology of Genital Ulcer Disease (GUD) in men, their association with clinical sign, complex of GUD and high-risk behavior were assessed. One hundred men with first episodes of genital ulcers were prospectively studied for serological evidence of syphilis (RPR and TPHA; T.pallidum IgM and IgG antibodies) and Polymerase Chain Reaction (PCR) proven chancroid and herpes. Demographic and epidemiological data were obtained in a standard interview. Positive syphilis serology observed in 11 cases, H. ducreyi detected in 65 cases and Herpes Simplex Virus in 13 cases. Among the PCR proven infections HSV type-2 detected in 7 cases, HSV type-1 in 4 cases and both HSV type-1 & 2 in 2 cases. Most of the HSV infections (92.3%) found as mixed infection with H. ducreyi. There was one PCR detected genital herpes case that was clinically undetermined. Among the PCR proven HSV infections clinical sign complex of genital herpes observed in one case, which had mixed microbial etiology. HSV infection was more prevalent in married than unmarried men (25.0% vs. 8.3%; P<0.05) and associated with early age promiscuous activity, multiple sexual partner, and sex with commercial sex workers and past infection with STDs. Presence of underdiagnosed HSV infection in men with GUD stress on the need for clinical suspicion of multiple infections. Patient with GUD should be carefully evaluated for HSV infection. Medicine Today 2010 Volume 22 Number 02 Page 55-61 DOI: http://dx.doi.org/10.3329/medtoday.v22i2.12430 

Cervicovaginal HIV-1 and herpes simplex virus type 2 shedding during genital ulcer disease episodes

AIDS ◽  
2007 ◽  
Vol 21 (12) ◽  
pp. 1569-1578 ◽  
Author(s):  
J??r??me LeGoff ◽  
Helen A Weiss ◽  
G??rard Gresenguet ◽  
Khonde Nzambi ◽  
Eric Frost ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Genital Ulcer ◽  
Ulcer Disease ◽  
Genital Ulcer Disease ◽  
Simplex Virus ◽  
Hiv 1
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