Prevalence of genital human papillomavirus DNA in a sample of senior school-aged women in the Australian Capital Territory

Sexual Health ◽  
2006 ◽  
Vol 3 (2) ◽  
pp. 91 ◽  
Author(s):  
Elissa J. O'Keefe ◽  
Anne Gardner ◽  
Marian J Currie ◽  
Suzanne Garland ◽  
Sepehr Tabrizi ◽  
...  
Keyword(s):  
Risk Factors ◽  
High School ◽  
Human Papillomavirus ◽  
Young Women ◽  
Hpv Infection ◽  
Senior High School ◽  
Sexually Active ◽  
Australian Capital Territory ◽  
Hpv Dna ◽  
Australian Capital

Background: A strong association between persistent infection with oncogenic types of human papillomavirus (HPV) and cervical cancer is well established. Small numbers of international studies examining adolescent HPV infection and the risk factors associated are published, but there is currently no evidence on the prevalence and risk factors for HPV in an Australian, sexually active female adolescent population. Methods: To provide prevalence and risk factors for HPV in a female sexually active, senior high school population in the Australian Capital Territory (ACT), a convenience sample of 161, 16–19-year-old females attending a senior high school was evaluated. The sample formed part of a larger sample recruited for a study of sexually transmitted infections and blood-borne viruses in senior high school students. A clinical record was used to collect information about sexual and other risk behaviours, while self-collected vaginal swabs were tested for HPV DNA detection and genotyping using polymerase chain reaction. Results: The prevalence of HPV DNA in this sample overall was 11.2%, with multiple genotypes in 38%. No statistically significant associations were found between HPV DNA and the number of male partners, age of coitarche, time since first sexually active, condom use, smoking or alcohol intake. Conclusions: This is the first Australian study that has examined the prevalence and risk factors for genital HPV in this demographic group. The prevalence of HPV infection is slightly lower than reported in similar age groups overseas and is lower than other Australian studies in older women and those attending sexual health centres. Of HPV-positive young women, high-risk genotypes were found in over half, with more than one-third of HPV existing as multiple genotypes. Large community-based prevalence studies are needed to guide the development of recommendations for the vaccination of young women against HPV and to support other health promotion initiatives.

scholarly journals Cervical human papillomavirus infection in Serbia: Risk factors, prevalence and genotype distribution in women with normal cervical cytology

2012 ◽  
Vol 64 (4) ◽  
pp. 1277-1283 ◽  
Author(s):  
Aleksandra Knezevic ◽  
Gordana Aleksic ◽  
I. Soldatovic ◽  
Ana Banko ◽  
Tanja Jovanovic
Keyword(s):  
Risk Factors ◽  
Human Papillomavirus ◽  
Young Women ◽  
Direct Sequencing ◽  
Hpv Infection ◽  
Cervical Cancer Prevention ◽  
Genotype Distribution ◽  
Normal Cytology ◽  
Hpv Dna ◽  
Hpv Genotypes

Sexual behavioral and other risk factors and the prevalence of genital human papillomavirus (HPV) infection are very important for the monitoring of HPV infection and cervical cancer prevention strategies. The purpose of this study was to determine the risk factors, prevalence of cervical HPV infection and genotype distribution among asymptomatic young women with normal cytology in Serbia. A total of 204 consenting young women were enrolled in this study and interviewed about risk factors. The presence of HPV DNA was assessed using the PCR method. HPV genotypes were identified by direct sequencing. Cervical HPV infection was detected in 19.1% of women. Out of nine identified HPV genotypes, types 16 and 52 were the most frequent. A significant association was found only between the number of sexual partners and HPV positivity (p<0.05). The obtained results showed the high prevalence of high-risk HPV types among young women in Serbia.

The role of circumcision, tobacco, and alcohol use in genital human papillomavirus infection among men from Denmark

2021 ◽  
pp. 095646242110147
Author(s):  
Julie B Hebnes ◽  
Christian Munk ◽  
Kirsten Frederiksen ◽  
Hans O Joergensen ◽  
Thomas Iftner ◽  
...  
Keyword(s):  
Risk Factors ◽  
Sexual Behavior ◽  
Human Papillomavirus ◽  
Alcohol Use ◽  
Potential Risk ◽  
Hpv Infection ◽  
Sex Partners ◽  
Current Cigarette Smoking ◽  
Hpv Dna ◽  
Potential Risk Factors

It is crucial to understand the natural history of genital human papillomavirus (HPV) infection in men to prevent the increasing male HPV-related disease burden. We evaluated the associations between HPV infection and circumcision, smoking, and alcohol use after accounting for sexual behavior. The study included 2331 male personnel from Danish barracks. Penile swabs were tested for HPV DNA with a polymerase chain reaction assay, INNO-LiPA. All men completed a self-administered questionnaire providing data on potential risk factors for HPV such as lifestyle and sexual habits. Using multivariable logistic regression, associations between potential risk factors and HPV infection were estimated and expressed as odds ratios (ORs) with 95% confidence intervals (CI). Current cigarette smoking was associated with increased odds of HPV detection (OR = 1.2; 95% CI: 1.0–1.4), but we found no association with alcohol use in the analysis adjusted for sexual behavior. Circumcision reduced the odds of a prevalent HPV infection (OR = 0.7; 95% CI: 0.5–1.0) although not statistically significantly. Strong associations with lifetime and recent number of female sex partners were observed, but in contrast to uncircumcised men, increasing number of sex partners was not associated with higher HPV prevalence in circumcised men. In conclusion, smoking was associated with increased odds of penile HPV in men from the general population in Denmark, whereas circumcision seemed to reduce the risk. Moreover, our results indicated that there might be differences in the viral susceptibility between circumcised and uncircumcised men.

Human papillomavirus prevalence in the oral cavity of men who have sex with men: a study of its first from Beirut, Lebanon

Sexual Health ◽  
2016 ◽  
Vol 13 (4) ◽  
pp. 397 ◽  
Author(s):  
Ismaël Maatouk ◽  
Khalil Abdo
Keyword(s):  
Human Papillomavirus ◽  
Oral Cavity ◽  
Hpv Infection ◽  
Sexually Active ◽  
Hiv Status ◽  
Geographic Variations ◽  
Hpv Dna ◽  
Hpv Prevalence ◽  
Sex With Men ◽  
Hiv Negative

Background: Human papillomavirus (HPV) infection is the most common sexually transmissible viral infection worldwide. HPV is highly prevalent in sexually active men who have sex with men (MSM). The main objective of this study is to assess HPV prevalence in the oral cavity of MSM from Beirut, Lebanon. Methods: From November 2015 to January 2016, 42 MSM were recruited using respondent-driven sampling and provided oral samples for HPV DNA and for linear array testing to detect HPV type. Results: In total, 28 (66.67%) HIV-negative and 14 (33.33%) HIV-positive MSM were included. Overall, HPV prevalence in the oral cavity was 10% (95% CI 0.93–19.07) among all participants, but there was no statistical difference according to HIV status. The HPV type was exclusively HPV-6. Conclusions: These findings did not find an urgent need for routine HPV prevalence and screening for cancers in the oral cavity of a MSM group in Lebanon; however, they confirm previous findings about geographic variations in HPV prevalences.

scholarly journals Prevalence and risk factors for oral human papillomavirus infection in Mexican HIV-infected men

10.21149/9834 ◽  
2018 ◽  
Vol 60 (6, nov-dic) ◽  
pp. 653
Author(s):  
Yuria Ablanedo-Terrazas ◽  
Karla Romero-Mora ◽  
María Gómez-Palacio ◽  
Claudia Alvarado-de la Barrera ◽  
Matilde Ruiz-Cruz ◽  
...  
Keyword(s):  
Risk Factors ◽  
Human Papillomavirus ◽  
Hpv Infection ◽  
Oral Infection ◽  
Behavioral Risk ◽  
Hiv Diagnosis ◽  
Hpv Dna ◽  
Papillomavirus Infection ◽  
Immunodeficiency Virus ◽  
Oral Hpv

Objective. To determine the prevalence and risk factors for oral high-risk human papillomavirus (HR-HPV) infection in human immunodeficiency virus (HIV)-infected men. Materials and methods. Consecutive male outpatients with HIV-infection were enrolled. Demographic and behavioral risk data were obtained. Anal swabs and oral rinses were tested for HR-HPV DNA. Oral, pharyngeal and video laryngoscopy examinations were performed for detection of lesions. Results. The prevalence of HR-HPV oral infection was 9.3% (subtypes other than HR HPV 16/18 predominated). The prevalence of anal HR-HPV infection was 75.7%. The risk factors for oral infection with HR-HPV were tonsillectomy (OR=13.12) and years from HIV diagnosis (OR=1.17). Conclusions. Tonsillectomy and years from HIV diagnosis were associated with oral HPV infection. No association was found between oral and anal HR-HPV infections. This is the first study reporting the prevalence and risk factors for oral HR-HPV infection in Mexican HIV-infected population.

scholarly journals Prevalence and genotype specific concordance of oro-genital and anal human papillomavirus infections among sexually active Nigerian women

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Imran O. Morhason-Bello ◽  
Kathy Baisley ◽  
Miquel Angel Pavon ◽  
Isaac F. Adewole ◽  
Rasheed Bakare ◽  
...  
Keyword(s):  
Risk Factors ◽  
Human Papillomavirus ◽  
Oral Cavity ◽  
Hpv Infection ◽  
Cross Sectional Study ◽  
Sub Saharan Africa ◽  
Sexually Active ◽  
Cross Sectional ◽  
Nigerian Women ◽  
Oral Hpv

Abstract Background Human papillomavirus (HPV) associated cancers are increasingly reported globally, including in sub-Saharan Africa (SSA). However, with the exception of cervical HPV infection, data from SSA on the epidemiology of oral and genital HPV infections are limited. This study assessed the prevalence and concordance of oro-genital and anal HPV genotype specific infections among women in the general population. Methods We conducted a cross-sectional study in sexually active women aged 18–45 years in Ibadan, Nigeria. After a face-to-face interview and clinical examination, oral, cervical, vulvar, and anal samples were collected from participants and tested by the Anyplex II 28 HPV assay. Descriptive and multivariable analyses were used to report prevalence and risk factors associated with HPV infections. Results The prevalence of any vulva, cervical, anal, and oral HPV infections was 68.0% (210/309), 59.7% (182/305), 56.8% (172/303), and 16.1% (14/286), respectively. There was an inverse relationship between age-group and HPV prevalence of HPV in all anatomic sites except for the oral HPV infections. HPV 35 was the most prevalent high-risk HPV genotype in the vulva, cervix and oral cavity. Associated risk factors for HPV infection in each of the anatomic sites were reported. Overall, 10.0% (31/310) women had concordance of any HPV type in the four anatomic sites. Conclusion There was a high prevalence of oro-genital and anal HPV infections among sexually active Nigerian women, with concordance of HPV types in the cervix, vulva, anus and oral cavity. We advocate large longitudinal studies that will involve sampling of multiple anatomic sites and inclusion of other women in the community for better understanding of HPV epidemiology in this region.

scholarly journals Persistence of cervical human papillomavirus infection among cohort of women in Awka, Nigeria

2021 ◽  
Vol 22 (3) ◽  
pp. 344-351
Author(s):  
C.U. Ezebialu ◽  
I.U. Ezebialu ◽  
C.C. Ezenyeaku
Keyword(s):  
Risk Factors ◽  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Facteurs De Risque ◽  
Hpv Infection ◽  
Low Grade ◽  
Hpv Dna ◽  
Papillomavirus Humain ◽  
Pcr En Temps Réel ◽  
Col De L’Utérus

Background: Many women are known to contract human papilloma virus (HPV) infection in their lifetime but only a few develop cervical cancer. One of the major factors that contribute to development of cervical cancer is HPV persistence. Several other factors including viral load have been implicated in cervical cancer development. This work therefore intends to investigate the persistence of cervical HPV infection among cohort of women in Awka, Nigeria.Methodology: A cohort of 58 women with normal Papanicolaou (Pap) test but positive HPV DNA selected from a population of 410 women at baseline were followed up over a period of 6 months from April to October 2015. Cervical specimens collected were subjected to HPV DNA test and viral quantification using TaqMan Real Time PCR and cervical cytology. Risk factors were obtained using semi structured interviewer administered questionnaires. Variables were analysed using descriptive statistics and T-test on IBM SPSS statistics version 21.0 and EPI INFOTM 7.0Results: At the 6-month follow up, cervical HPV infection persisted in 29 women, representing 50% of the women followed up. Among the 29 women, 7 (24.1%) developed abnormal Pap smear (Low grade Squamous Intraepithelial Lesion). Factors significantly associated with persistence at bivariate analysis of HPV include previous sexually transmitted infection (STI) (p=0.005), HIV positivity (p=0.04), HIV positivity but no anti-retroviral drugs (p=0.014), HPV 16 infection (p<0.0001) and age less than 40 years (p<0.0001). At multinomial logistic regression, only age above 17 years at first sexual intercourse (p=0.003, CI=0.012-0.392) and multiple lifetime sexual partners (p=0.021, CI=0.20-0.726) were statistically significant.Conclusion: High risk HPV infection, in addition to other factors peculiar to an individual may influence HPV persistenceKey words: cervical cancer, human papillomavirus, persistence, cytology, risk factors, infection   French Title: Persistance de l'infection cervicale par le papillomavirus humain parmi une cohorte de femmes à Awka, Nigéria Contexte: De nombreuses femmes sont connues pour contracter une infection au virus du papillome humain (VPH) au cours de leur vie, mais seules quelques-unes développent un cancer du col de l'utérus. L'un des principaux facteurs qui contribuent au développement du cancer du col de l'utérus est la persistance du VPH. Plusieurs autres facteurs, y compris la charge virale, ont été impliqués dans le développement du cancer du col de l'utérus. Ce travail vise donc à étudier la persistance de l'infection cervicale au VPH parmi la cohorte de femmes à Awka, au Nigeria. Méthodologie: Une cohorte de 58 femmes avec un test de Papanicolaou (Pap) normal mais un ADN HPV positif sélectionné parmi une population de 410 femmes au départ ont été suivis sur une période de 6 mois d'avril à octobre 2015. Les échantillons cervicaux collectés ont été soumis à l'ADN HPV. test et quantification virale à l'aide de la PCR en temps réel TaqMan et de la cytologie cervicale. Les facteurs de risque ont été obtenus à l'aide de questionnaires semi-structurés administrés par les intervieweurs. Les variables ont été analysées à l'aide de statistiques descriptives et d'un test T sur IBM SPSS statistics version 21.0 et EPI INFOTM 7.0 Résultats: Au suivi de 6 mois, l'infection cervicale au VPH persistait chez 29 femmes, soit 50% des femmes suivies. Parmi les 29 femmes, 7 (24,1%) ont développé un test Pap anormal (lésion squameuse intraépithéliale de bas grade). Les facteurs significativement associés à la persistance lors de l'analyse bivariée du VPH comprennent les antécédents d'infection sexuellement transmissible (IST) (p=0,005), la positivité au VIH (p=0,04), la positivité au VIH mais pas d'antirétroviraux (p=0,014), l'infection au VPH 16 (p<0,0001) et moins de 40 ans (p<0,0001). Lors de la régression logistique multinomiale, seuls les âges supérieurs à 17 ans lors du premier rapport sexuel (p=0,003, IC=0,012-0,392) et les multiples partenaires sexuels à vie (p=0,021, IC=0,20-0,726) étaient statistiquement significatifs. Conclusion: Une infection au VPH à haut risque, en plus d'autres facteurs propres à un individu, peut influencer la persistance du VPH Mots clés: cancer du col de l'utérus, papillomavirus humain, persistance, cytologie, facteurs de risque, infection  

scholarly journals Prevalence of oral human papillomavirus (HPV) in the adult population of Córdoba, Argentina

2018 ◽  
Vol 3 ◽  
pp. 2057178X1875733 ◽  
Author(s):  
MI Criscuolo ◽  
PA Belardinelli ◽  
RA Morelatto ◽  
J Mosmann ◽  
RF Venezuela ◽  
...  
Keyword(s):  
Risk Factors ◽  
Human Papillomavirus ◽  
Oral Mucosa ◽  
Adult Population ◽  
Saliva Sample ◽  
High Water ◽  
Hpv Infection ◽  
Low Risk ◽  
Hpv Dna ◽  
Number Of Sexual Partners

Objective: To determine the prevalence of oral human papillomavirus (HPV) in the population of Córdoba, Argentina and its association with other risk factors. Methods: A sample of 401 volunteers over 18 years, representative of Cordoba city population, was selected. Using a questionnaire, we collected sociodemographic data including the use of tobacco, alcohol, and mate consumption. Two biological samples were taken from each individual, whole mouth saliva and a scraping of the posterior border of the tongue. HPV was determined by polymerase chain reaction using MY09/11 primers. Statistical associations were analyzed using χ2 test. Results: Prevalence of HPV in the population was of 3% (13/401). The mean age of HPV-positive cases was 42 years with a range of 20–85; 54% were females. Among the 13 cases whose saliva was positive for HPV, only 7 (54%) had HPV-DNA in the tongue scraping. All identified genotypes were of low risk and HPV11 was the most frequent type in 62% of positive cases. None of the positive subjects exhibited oral lesions compatible with HPV infection. Ten (77%) of the HPV-positive subjects exhibited lesions in the oral mucosa, mostly related to chronic mechanical irritation (CMI) (odds ratio 3, 95% confidence interval: 1.01–8.97, p < 0.05). Fifty-four percent of HPV-positive individuals were light smokers and consumed alcohol moderately. The combination of both habits was observed in 31%. Sixty-two percent drank mate at high water temperatures. No differences were detected in the sexual behavior or in the reported number of sexual partners between HPV-positive and -negative subjects. Conclusion: The overall prevalence of oral HPV in adults was 3%; only the low-risk genotypes were detected and no association with other risk factors for oral cancer was found. However, an association with CMI of the oral mucosa was noted. The saliva sample proved to be a simple, efficient, and well-tolerated method suitable for screening for HPV, and more cases were detected in saliva compared with tissue scrapings.

scholarly journals Biomolecular Study of the Correlation Between Papillomatosis of the Vulvar Vestibule in Adolescents and Human Papillomavirus

2006 ◽  
Vol 6 ◽  
pp. 628-636 ◽  
Author(s):  
Geni Beznos ◽  
Veronica Coates ◽  
Jose Focchi ◽  
Hatim A. Omar
Keyword(s):  
Human Papillomavirus ◽  
Histological Study ◽  
Hpv Infection ◽  
Fisher Exact Test ◽  
Sexually Active ◽  
Exact Test ◽  
Hpv Dna ◽  
Significant Difference ◽  
Group A ◽  
Group B

The main goal of this study was to investigate, through a biomolecular study, the correlation between papillomatosis of the vulvar vestibule and human papillomavirus (HPV) infection, as well as to establish the necessity of treatment. A total of 44 female adolescents between 12 and 18 years of age were selected through a prospective study with a confirmed diagnosis of papillomatosis of the vulvar vestibule. Vulvar biopsies were obtained for the histological and biomolecular detection of HPV DNA through polymerase chain reaction (PCR). Twenty (45%) adolescents were virgins (group A), the other 24 (55%) were sexually active. The virgin adolescents (group A) and 12 sexually active adolescents (group B) did not show cytological and/or colposcopic alteration, suggesting infection by HPV either on the cervix or vagina. These were compared with 12 other sexually active adolescents who showed cervicovaginal infection caused by HPV (group C). Fisher exact test was applied for statistical analysis of the results, considering alpha equal or less than 0.05. There was no statistically significant difference in relation to HPV DNA through PCR among virgin and sexually active adolescents in group B, however, both differed from those in group C (A + B × C:p= 0.048*). The histological study did not reveal evident signs of infection caused by HPV on vestibular papillae, besides perinuclear halos. HPV DNA was detected on vestibular papillae in 27%. Our results confirmed a scarce correlation between vestibular papillae and HPV. Thus, we consider papillomatosis of the vulvar vestibule, in most cases, to be equivalent to physiological papillomatosis and, therefore, should not be treated.

scholarly journals Risk factors for cervical presence of human papillomavirus DNA among women at risk for HIV infection

1998 ◽  
Vol 121 (1) ◽  
pp. 173-177 ◽  
Author(s):  
G. REZZA ◽  
M. GIULIANI ◽  
D. SERRAINO ◽  
M. BRANCA ◽  
A. BENEDETTO ◽  
...  
Keyword(s):  
Risk Factors ◽  
At Risk ◽  
Human Papillomavirus ◽  
Hiv Infection ◽  
Structured Interview ◽  
Hpv Infection ◽  
Sexual Partners ◽  
Hpv Dna ◽  
Cervical Infection ◽  
Hiv Serostatus

Risk factors for cervical infection with human papillomavirus (HPV) were assessed among 236 Italian women at risk for human immunodeficiency virus (HIV) infection (intravenous drug users (IVDU) or sexual partners of males at risk for HIV infection). All study participants underwent a structured interview, determination of HIV serostatus and detection of HPV cervical infection by means of polymerase chain reaction (PCR). Overall, the cervical presence of HPV DNA was ascertained in 86 of these 236 women (36·4%), while squamous intraepithelial lesions (SIL) were diagnosed in 57 (24·1%). HPV-infected and non-infected women did not differ in age, education and cigarette smoking. A statistically significant trend in the risk of HPV infection with increasing number of lifetime sexual partners was noted (P=0·01), but such trend was attenuated in multivariate analysis (multiple logistic regression (MLR) odds ratio (OR) for [ges ]20 partners vs 1=1·6, 95% confidence intervals (CI): 0·4–5·9). A nearly threefold higher risk of HPV cervical infection emerged among IVDU women (MLR–OR: 2·7, 95% CI: 1·4–5·0), and this difference was not influenced by HIV serostatus. The prevalence of HIV infection was higher among HPV-positive than HPV-negative women (62·8% and 54·0%, respectively) (MLR–OR=1·9, 95% CI: 0·9–3·8), and the proportion of women with less than 200 CD4+ cells/mm3 was slightly and not significantly higher among HPV-positive (47·1%) than negative women (37·2%).

scholarly journals Prevalence and genotype distribution of human papillomavirus in Czech non-vaccinated heterosexual couples

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Hana Jaworek ◽  
Vladimira Koudelakova ◽  
Ivana Oborna ◽  
Blazena Zborilova ◽  
Jana Brezinova ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Hpv Infection ◽  
Sexual Partners ◽  
Fisher Exact Test ◽  
Genotype Distribution ◽  
Heterosexual Couples ◽  
Anatomic Site ◽  
Hpv Dna ◽  
Hpv Test ◽  
Penile Swabs

Abstract Background Data about the genotype-specific human papillomavirus (HPV) prevalence in the Czech Republic is limited. We aimed to evaluate the prevalence and concordance of genotype-specific HPV infection detected in semen samples, penile swabs and cervical swabs from non-vaccinated heterosexual couples without HPV-associated disease. Methods Semen samples and penile swabs were collected from male partners and cervical swabs were collected from female partners of heterosexual couples treated for infertility (n = 195). Presence of HPV DNA in semen samples and cervical swabs was analyzed using the cobas® HPV Test and PapilloCheck®. Only the PapilloCheck® test was used to detect HPV in penile swabs. The genotype-specific prevalence and concordance of HPV infection not targeted by vaccine were evaluated using Fisher exact test. Results Both partners were infected with any HPV type in 13.8% (27/195) of couples and, of these couples, 55.6% (15/27) harbored at least one mutual genotype. High-risk HPV (hrHPV) genotypes were detected in 12.3% (24/195) of semen samples, 31.3% (61/195) of penile swabs, and 19.5% (38/195) of cervical swabs (P < 0.001). The most prevalent hrHPV genotype were HPV53 (2.56%; 5/195) in semen samples, HPV16 (6.67%, 13/195) in penile swabs and HPV39 (3.59%, 7/195) in cervical swabs. Low-risk (lrHPV) genotypes were detected in 5.13% (10/195) of semen samples, 15.9% (31/195) of penile swabs, and 4.10% (8/195) of cervical swabs (P < 0.001). Male sexual partners of HPV-positive women were more likely to be infected with at least one of the same HPV types than female sexual partners of HPV-positive men (34.9% vs. 17.9%, P = 0.055). Conclusions This study showed that the detection of HPV infection differ by anatomic site and gender. Regardless the anatomic site, high prevalence of HPV genital infection was found in both Czech men and women.

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