Commercialising genetically engineered animal biomedical products

2008 ◽  
Vol 20 (1) ◽  
pp. 61 ◽  
Author(s):  
Eddie J. Sullivan ◽  
Jerry Pommer ◽  
James M. Robl
Keyword(s):  
Biomedical Applications ◽  
Gap Analysis ◽  
Early Stage ◽  
Genetically Engineered ◽  
The Public ◽  
Public Benefit ◽  
The Past ◽  
Cell Banking ◽  
Stage Development ◽  
Founder Animal

Research over the past two decades has increased the quality and quantity of tools available to produce genetically engineered animals. The number of potentially viable biomedical products from genetically engineered animals is increasing. However, moving from cutting-edge research to development and commercialisation of a biomedical product that is useful and wanted by the public has significant challenges. Even early stage development of genetically engineered animal applications requires consideration of many steps, including quality assurance and quality control, risk management, gap analysis, founder animal establishment, cell banking, sourcing of animals and animal-derived material, animal facilities, product collection facilities and processing facilities. These steps are complicated and expensive. Biomedical applications of genetically engineered animals have had some recent successes and many applications are well into development. As researchers consider applications for their findings, having a realistic understanding of the steps involved in the development and commercialisation of a product, produced in genetically engineered animals, is useful in determining the risk of genetic modification to the animal v. the potential public benefit of the application.

scholarly journals Early Stage Development Of Geography Modules Of Design-Based Planning In The Study Program Of Education Geography STKIP PGRI West Sumatera

2017 ◽  
Vol 6 (4) ◽  
Author(s):  
Yusutria Yusutria ◽  
Nefilinda Nefilinda
Keyword(s):  
Early Stage ◽  
Study Program ◽  
Development Study ◽  
The Public ◽  
Faith Based ◽  
Initial Validation ◽  
Lecture Material ◽  
Stage Development

The purpose of this research is to develop a faith-based disaster geography module. The module is one source of learning for students, which can facilitate students to get information and easy to apply to the public, so it can be instrumental in facing disaster. The development study used a 4D model involving three steps namely: define, design, and develop. The instruments used are validation, activities and interviews. The define phase showed that the geography lecture material of disaster is in conformity with the standards of competence and achievement lecture. The results showed that the design module validation is valid enough according to the criteria and many improvements. However, the results described here is an initial validation, and therefore still need to be validated by disaster experts, educational experts and Indonesian language experts.

scholarly journals “The Greatest Slovak” in the Historical Memory of Modern Slovakia

2020 ◽  
Vol 162 (6) ◽  
pp. 185-193
Author(s):  
O.S. Krylova ◽  
◽  
G.V. Rokina ◽  
Keyword(s):  
Slovak Republic ◽  
Early Stage ◽  
Historical Memory ◽  
Radio Station ◽  
The Public ◽  
The Past ◽  
Stage Of Development ◽  
Public Survey ◽  
Historical Figures ◽  
Places Of Memory

The development and preservation of historical memory in the Slovak Republic were discussed using the Slovak pantheon of national heroes as an example. The study aims to show commemorative practices used in the historical development of the country. The mechanisms and tools for defining the collective historical memory of Slovaks in the modern times were considered. Some examples of the political use of memories of the past were analyzed. The title of the paper traces back to the public survey about “the greatest Slovak” arranged by the Slovak radio station and television in May 2018–October 2019. A number of examples illustrating the process of formation of historical myths and stereotypes in the collective historical memory of Slovaks over several centuries were provided. In modern Slovakia, the public is generally rejecting the old stereotypes and new myths are emerging against the background of heated discussions between politicians and historians. A simultaneous destruction of the old “places of memory” and the formation of the new ones is taking place. Furthermore, the traditional pantheon of Slovak national heroes is being updated. These processes have a considerable influence on the development of the country. In this work, special attention was paid to such historical figures of Slovakia as L. Štúr, the Founding Father of the Slovak nation, and M.R. Štefánik, the outstanding politician. The results of the television survey were analyzed in detail: the public had to choose 100 most outstanding personalities of the Slovak history, politics, and culture, as well as to determine “the greatest Slovak” among them. The latter title was finally awarded to M.R. Štefánik. It was concluded that the collective historical memory in Slovakia is at its early stage of development and that Slovaks have not fully overcome the myths and stereotypes of the past.

scholarly journals Laboratory Diagnosis of SARS-CoV-2 Pneumonia

Diagnostics ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1270
Author(s):  
Melissa R. Gitman ◽  
Maryia V. Shaban ◽  
Alberto E. Paniz-Mondolfi ◽  
Emilia M. Sordillo
Keyword(s):  
Respiratory Tract ◽  
Early Stage ◽  
Laboratory Diagnosis ◽  
Nucleic Acid Amplification ◽  
Health Economy ◽  
Diagnostic Strategies ◽  
The Public ◽  
Viral Spread ◽  
The Past ◽  
Antigen Tests

The emergence and rapid proliferation of Coronavirus Disease-2019, throughout the past year, has put an unprecedented strain on the global schema of health infrastructure and health economy. The time-sensitive agenda of identifying the virus in humans and delivering a vaccine to the public constituted an effort to flatten the statistical curve of viral spread as it grew exponentially. At the forefront of this effort was an exigency of developing rapid and accurate diagnostic strategies. These have emerged in various forms over the past year—each with strengths and weaknesses. To date, they fall into three categories: (1) those isolating and replicating viral RNA in patient samples from the respiratory tract (Nucleic Acid Amplification Tests; NAATs), (2) those detecting the presence of viral proteins (Rapid Antigen Tests; RATs) and serology-based exams identifying antibodies to the virus in whole blood and serum. The latter vary in their detection of immunoglobulins of known prevalence in early-stage and late-stage infection. With this review, we delineate the categories of testing measures developed to date, analyze the efficacy of collecting patient specimens from diverse regions of the respiratory tract, and present the up and coming technologies which have made pathogen identification easier and more accessible to the public.

scholarly journals Effective mitigation strategy in early stage of COVID-19 pandemic in China

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Xiao-Yue Yu ◽  
Chen Xu ◽  
Hu-Wen Wang ◽  
Rui-Jie Chang ◽  
Yin-Qiao Dong ◽  
...  
Keyword(s):  
Public Health ◽  
Early Stage ◽  
Mitigation Strategy ◽  
Health Interventions ◽  
Public Health Interventions ◽  
Epidemic Control ◽  
The Public ◽  
The Past ◽  
Health Measures ◽  
Global Pandemic

Abstract In the past five months, success in control the national epidemic of coronavirus disease 2019 (COVID-19) has been witnessed in China. The implementation of public health measures accounts for the success which include different interventions in the early or later stages of the outbreak. It is clear that although not all measures were universally effective worldwide, their achievements have been significant. More solidarity is needed to deal with this global pandemic with more learning and understanding. Understanding which of the public health interventions implemented in China were effective may provide ideas for international epidemic control.

How SIMS microscopy can be used in medicine

1992 ◽  
Vol 50 (2) ◽  
pp. 1602-1603
Author(s):  
Philippe Fragu
Keyword(s):  
Mass Spectrometry ◽  
Biomedical Applications ◽  
Secondary Ion Mass Spectrometry ◽  
Chemical Elements ◽  
Biological Applications ◽  
The Past ◽  
Potential Source ◽  
Secondary Ion ◽  
Chemical Integrity ◽  
Scientific Endeavour

The identification, localization and quantification of intracellular chemical elements is an area of scientific endeavour which has not ceased to develop over the past 30 years. Secondary Ion Mass Spectrometry (SIMS) microscopy is widely used for elemental localization problems in geochemistry, metallurgy and electronics. Although the first commercial instruments were available in 1968, biological applications have been gradual as investigators have systematically examined the potential source of artefacts inherent in the method and sought to develop strategies for the analysis of soft biological material with a lateral resolution equivalent to that of the light microscope. In 1992, the prospects offered by this technique are even more encouraging as prototypes of new ion probes appear capable of achieving the ultimate goal, namely the quantitative analysis of micron and submicron regions. The purpose of this review is to underline the requirements for biomedical applications of SIMS microscopy.Sample preparation methodology should preserve both the structural and the chemical integrity of the tissue.

Hospitals: N.Y. Appellate Court Denies Move to Privatize Public Hospital

1999 ◽  
Vol 27 (2) ◽  
pp. 202-203
Author(s):  
Robert Chatham
Keyword(s):  
New York ◽  
New York City ◽  
York City ◽  
Public Health System ◽  
Municipal Hospital ◽  
The Public ◽  
Public Benefit ◽  
For Profit ◽  
Benefit Corporation ◽  
The City

The Court of Appeals of New York held, in Council of the City of New York u. Giuliani, slip op. 02634, 1999 WL 179257 (N.Y. Mar. 30, 1999), that New York City may not privatize a public city hospital without state statutory authorization. The court found invalid a sublease of a municipal hospital operated by a public benefit corporation to a private, for-profit entity. The court reasoned that the controlling statute prescribed the operation of a municipal hospital as a government function that must be fulfilled by the public benefit corporation as long as it exists, and nothing short of legislative action could put an end to the corporation's existence.In 1969, the New York State legislature enacted the Health and Hospitals Corporation Act (HHCA), establishing the New York City Health and Hospitals Corporation (HHC) as an attempt to improve the New York City public health system. Thirty years later, on a renewed perception that the public health system was once again lacking, the city administration approved a sublease of Coney Island Hospital from HHC to PHS New York, Inc. (PHS), a private, for-profit entity.

The Suffering of the Perpetrators: The Ethics of Traumatic German Historicity in Karen Bass's Young Adult World War II Novels

2014 ◽  
Vol 7 (1) ◽  
pp. 64-77
Author(s):  
Doris Wolf
Keyword(s):  
World War Ii ◽  
Young Adult ◽  
Public Sphere ◽  
Childhood Studies ◽  
Historical Narratives ◽  
World War ◽  
The Public ◽  
The Past ◽  
Adult World ◽  
The Public Sphere

This paper examines two young adult novels, Run Like Jäger (2008) and Summer of Fire (2009), by Canadian writer Karen Bass, which centre on the experiences of so-called ordinary German teenagers in World War II. Although guilt and perpetration are themes addressed in these books, their focus is primarily on the ways in which Germans suffered at the hands of the Allied forces. These books thus participate in the increasingly widespread but still controversial subject of the suffering of the perpetrators. Bringing work in childhood studies to bear on contemporary representations of German wartime suffering in the public sphere, I explore how Bass's novels, through the liminal figure of the adolescent, participate in a culture of self-victimisation that downplays guilt rather than more ethically contextualises suffering within guilt. These historical narratives are framed by contemporary narratives which centre on troubled teen protagonists who need the stories of the past for their own individualisation in the present. In their evacuation of crucial historical contexts, both Run Like Jäger and Summer of Fire support optimistic and gendered narratives of individualism that ultimately refuse complicated understandings of adolescent agency in the past or present.

The End of History Museums: What's Plan B??

2008 ◽  
Vol 30 (4) ◽  
pp. 9-27 ◽  
Author(s):  
Cary Carson
Keyword(s):  
Historic Sites ◽  
The Public ◽  
End Of History ◽  
House Museums ◽  
The Past ◽  
History Museums ◽  
Plan B ◽  
The End Of History ◽  
The Way

Abstract Are historic sites and house museums destined to go the way of Oldsmobiles and floppy disks?? Visitation has trended downwards for thirty years. Theories abound, but no one really knows why. To launch a discussion of the problem in the pages of The Public Historian, Cary Carson cautions against the pessimistic view that the past is simply passéé. Instead he offers a ““Plan B”” that takes account of the new way that learners today organize information to make history meaningful.

E-Projects Challenges in India – Role of Human Resource Management and Technology

2018 ◽  
Vol 6 (8) ◽  
pp. 263
Author(s):  
Ramnik Kaur
Keyword(s):  
Developing Countries ◽  
Public Administration ◽  
Paradigm Shift ◽  
Successful Implementation ◽  
The Public ◽  
Government Services ◽  
The Past ◽  
The Government ◽  
Traditional Approaches

E-governance is a paradigm shift over the traditional approaches in Public Administration which means rendering of government services and information to the public by using electronic means. In the past decades, service quality and responsiveness of the government towards the citizens were least important but with the approach of E-Government the government activities are now well dealt. This paper withdraws experiences from various studies from different countries and projects facing similar challenges which need to be consigned for the successful implementation of e-governance projects. Developing countries like India face poverty and illiteracy as a major obstacle in any form of development which makes it difficult for its government to provide e-services to its people conveniently and fast. It also suggests few suggestions to cope up with the challenges faced while implementing e-projects in India.

التأثيرات السياسية في استدامة الدين العام في موازنة العراق 2019

2020 ◽  
Vol 2020 (66) ◽  
pp. 1-26
Author(s):  
م.م أحمد حامد جمعة ◽  
◽  
د. كمال فيلد البصري
Keyword(s):  
Public Debt ◽  
Public Spending ◽  
The Political ◽  
Financial Policy ◽  
Public Expenditures ◽  
Public Budget ◽  
Political Decision ◽  
The Public ◽  
Public Benefit ◽  
Political Impact

This study clarifies the analysis of the reality of the financial policy in the budget of Iraq 2019, and that analysis is evaluated by tracking the elements of the public budget from public expenditures and public revenues, and the study focuses on the size of the political impact on the path of public spending, as well as the analysis of public spending and revenues in various sectors and sections of the public budget. This study also shows the size of the risks resulting from the continuation of the financial deficit, as well as the risks of public debt according to the indicators of its sustainability analysis within the financial and economic indicators that express the risks of public debt. The study emphasized that public spending is still based on the political decision and does not achieve the principles and objectives of the economic budget that achieve the public benefit. The necessity requires efficient spending and fair distribution in order to avoid future public debt risks and their impact on future generations

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