scholarly journals Commonalities in Metabolism of Arsenicals

2005 ◽  
Vol 2 (3) ◽  
pp. 161 ◽  
Author(s):  
Blakely M. Adair ◽  
Stephen B. Waters ◽  
Vicenta Devesa ◽  
Zuzana Drobna ◽  
Miroslav Styblo ◽  
...  
Keyword(s):  
At Risk ◽  
Drinking Water ◽  
Health Effects ◽  
Inorganic Arsenic ◽  
Environmental Context ◽  
Arsenic Metabolism ◽  
Toxic Species ◽  
Increased Risk ◽  
Contaminated Drinking Water ◽  
Carcinogenic Effects

Environmental Context. Health effects associated with inorganic arsenic include various cancers and increased risk of diabetes. Millions of people in Bangladesh and India are at risk through use of contaminated drinking water. When humans ingest inorganic arsenic, it is rapidly converted to methylated metabolites. Although this methylation process is largely understood, the metabolism of other arsenicals (e.g. arsenosugars to dimethylarsenic) is very unclear. Connections among pathways for metabolism of various arsenicals are now being elucidated. Commonalities and differences in these pathways may be important determinants of the risk associated with exposure to these agents. Abstract. Elucidating the pathway of inorganic arsenic metabolism shows that some of methylated arsenicals formed as intermediates and products are reactive and toxic species. Hence, methylated arsenicals likely mediate at least some of the toxic and carcinogenic effects associated with exposure to arsenic. Trimethylarsonium compounds and arsenosugars are two other classes of arsenicals to which humans are routinely exposed and there is evidence that both classes are metabolized to produce methylated arsenicals. Here, we review evidence for production of methylated metabolism and consider the challenges posed in unraveling a complex web for metabolism of arsenicals in humans.

Arsenic exposure and non-carcinogenic health effects

2021 ◽  
pp. 096032712110459
Author(s):  
Macario Martínez-Castillo ◽  
Eliud A García-Montalvo ◽  
Mónica G Arellano-Mendoza ◽  
Luz del C Sánchez-Peña ◽  
Luis E Soria Jasso ◽  
...  
Keyword(s):  
Drinking Water ◽  
Abdominal Pain ◽  
Urinary Tract ◽  
Health Effects ◽  
Health Problem ◽  
Molecular Mechanisms ◽  
Arsenic Exposure ◽  
Inorganic Arsenic ◽  
Severe Diarrhea ◽  
Contaminated Drinking Water

Inorganic arsenic (iAs) exposure is a serious health problem that affects more than 140 million individuals worldwide, mainly, through contaminated drinking water. Acute iAs poisoning produces several symptoms such as nausea, vomiting, abdominal pain, and severe diarrhea, whereas prolonged iAs exposure increased the risk of several malignant disorders such as lung, urinary tract, and skin tumors. Another sensitive endpoint less described of chronic iAs exposure are the non-malignant health effects in hepatic, endocrine, renal, neurological, hematological, immune, and cardiovascular systems. The present review outlines epidemiology evidence and possible molecular mechanisms associated with iAs-toxicity in several non-carcinogenic disorders.

Pesticide Contaminated Drinking Water and Health Effects on Pregnant Women and Children

2019 ◽  
pp. 123-136
Author(s):  
Sanjeevi Ramakrishnan ◽  
Anuradha Jayaraman
Keyword(s):  
Drinking Water ◽  
High Risk ◽  
Health Outcomes ◽  
Pregnant Women ◽  
Health Effects ◽  
Pesticide Residues ◽  
Contaminated Water ◽  
Adverse Health Outcomes ◽  
Contaminated Drinking Water ◽  
Women And Children

In the recent years, pesticide research and regulatory efforts have focused on the prevention of acute health effects from pesticide poisonings and pesticide residues on foods, but more attention is being given to the deleterious chronic health effects. Children and pregnant women's exposure to contaminated water in particular are at high risk for subsequent adverse health outcomes. The chapter summaries the health effects of water contamination.

scholarly journals Variation in Arsenic metabolism in schistosomiasis associated bladder pathology in a rural community, Eggua, Ogun State, Nigeria

2021 ◽  
Vol 25 (9) ◽  
pp. 1645-1652
Author(s):  
A.T. Adeboye ◽  
H.O. Awobode ◽  
A.S. Adebayo ◽  
J.R. Djouaka ◽  
R.D. Isokpehi ◽  
...  
Keyword(s):  
Arsenic Concentration ◽  
Arsenic Exposure ◽  
Inorganic Arsenic ◽  
Urogenital Schistosomiasis ◽  
Arsenic Metabolism ◽  
Ogun State ◽  
Specific Pcr ◽  
Urinary Arsenic ◽  
Increased Risk ◽  
Bladder Pathology

Exposure to toxic inorganic Arsenic (iAs) in areas endemic for urogenital schistosomiasis may confer increased risk for bladder cancer. The severity of the adverse effects of iAs however depends on its metabolism, which is highly variable among individuals. Genetic polymorphism in Arsenic (+3) Methyl Transferase enzyme, accounts significantly for these variations. To investigate the relationship of AS3MT gene polymorphisms and Arsenic metabolism to schistosomiasis and/or associated bladder pathology, 119 individualsfrom Eggua in southwest Nigeria were recruited for this study. Screening for schistosomiasis and bladder pathology was done by microscopy and ultrasonography respectively. Wagtech Digital Arsenator was used to assess total urinary arsenic concentrations and thus determine the level of arsenic exposure. The single nucleotide polymorphism AS3MT/Met287Thr T>C (rs11191439) was genotyped using Alelle-Specific PCR. Of the participants who tested positive for schistosomiasis, 33.3% exhibited bladder pathology. Total urinary arsenic concentration in 80% of the participants was above the WHO limit of 0.05mg/L. The Met287Thr allelic distribution conformed to the Hardy-Weinberg equilibrium (X2= 0.161, P> 0.05). Observed allelic frequencies were 0.96 and 0.04 for wild-type T and mutant C alleles respectively. There was no significant relationship between AS3MT SNP, arsenic concentrations and schistosomiasis associated bladder pathology. In conclusion, the community is highly exposed to arsenic, although with a possible genetic advantage of increased AS3MT catalytic activity. However, we see the need for urgent intervention as inter-individual differences in arsenic metabolism may influence the bladder pathology status of individuals in the community. And although urogenital schistosomiasis is waning in Eggua, it is not known what synergy the infection and high arsenic exposure may wield on bladder pathology.

Human health risk assessment of 2-mercaptobenzothiazole in drinking water

2004 ◽  
Vol 20 (6-10) ◽  
pp. 149-163 ◽  
Author(s):  
Margaret H Whittaker ◽  
Ann Marie Gebhart ◽  
Thea Clipson Miller ◽  
Frank Hammer
Keyword(s):  
Risk Assessment ◽  
Drinking Water ◽  
Human Health ◽  
Health Effects ◽  
Renal Pelvis ◽  
Human Health Risk ◽  
Risk Of Death ◽  
Increased Risk ◽  
Occupationally Exposed ◽  
Action Levels

2-Mercaptobenzothiazole (MBT) is used as a vulcanization accelerator in rubber products that come into contact with potable drinking water. When such products are evaluated for contact with potable water and submitted for ANSI/NSF Standard 61 certification, any chemical extracting from these products must be below an appropriate action level of exposure. As defined by Standard 61, a total allowable concentration (TAC) is the maximum concentration of a nonregulated contaminant allowed in a public drinking water supply, and the single product allowable concentration (SPAC) is 10% of the TAC. Currently, MBT has a TAC of 40 mg/L and a SPAC of 4 mg/L. A comprehensive health effects evaluation of MBT was performed to determine whether these action levels should be revised. Epidemiological investigations indicate that workers occupationally exposed to MBT have an increased risk of death from bladder cancer. Genotoxicity investigations in bacterial and mammalian test systems provide some evidence indicating that MBT has the potential to induce mutations and chromosomal aberrations. Toxicity studies in rats and mice chronically exposed to MBT identified increases in various tumours, such as adrenal gland tumours, pituitary gland tumours, liver tumours and renal pelvis tumours. The biological significance of most of these tumours is questionable due to a variety of factors, such as a lack of dose-response between tumour incidence and dose, and the effect of test article vehicle (corn oil) upon tumour rates. Potential human health effects of exposure to MBT can be predicted from an NTP 2-year cancer study in rats, as well as epidemiological investigations in occupationally exposed workers. A comprehensive review of the epidemiological and toxicological dataset for MBT indicates that the induction of renal pelvis transitional cell tumours is the most sensitive and relevant health effects endpoint upon which to base a revised TAC and SPAC. A multistage model was used to extrapolate to low-dose MBT exposures due to the genotoxicity and clastogenicity of MBT. A TAC of 600 mg/L was derived for MBT, and was based upon an LED10 of 157.681 mg/kg per day. A SPAC of 60 mg/L was derived by multiplying the revised TAC by 0.10, and rounding to one significant figure. These revised action levels are based upon the most sensitive health effects endpoint, as well as current cancer risk assessment methodology.

Quantitative toxicological study of dose-dependent arsenic-induced cells via synchrotron-based STXM and FTIR measurement

The Analyst ◽  
2020 ◽  
Vol 145 (13) ◽  
pp. 4560-4568
Author(s):  
Junshan Xiu ◽  
Yunyan Liu ◽  
Benyi Wang ◽  
Yanling Xue ◽  
Min Chen ◽  
...  
Keyword(s):  
Drinking Water ◽  
Inorganic Arsenic ◽  
Toxicological Study ◽  
Human Carcinogen ◽  
Naturally Occurring ◽  
Contaminated Drinking Water ◽  
Dose Dependent

Inorganic arsenic (iAs) is a well-known naturally occurring metalloid with abundant hazards to our environment, especially being a human carcinogen through arsenic-contaminated drinking water.

Case–control study of male cancer patients exposed to arsenic-contaminated drinking water and tobacco smoke with relation to non-exposed cancer patients

2011 ◽  
Vol 30 (12) ◽  
pp. 2013-2022 ◽  
Author(s):  
Sham Kumar Wadhwa ◽  
Tasneem Gul Kazi ◽  
Nida Fatima Kolachi ◽  
Hassan Imran Afridi ◽  
Sumaira Khan ◽  
...  
Keyword(s):  
Drinking Water ◽  
Cancer Patients ◽  
Biological Samples ◽  
Inorganic Arsenic ◽  
Different Types ◽  
Big City ◽  
Male Cancer Patient ◽  
Contaminated Drinking Water ◽  
Male Subjects ◽  
Control Study

The investigated data indicated that inorganic arsenic in drinking water is associated with increased mortality from different types of cancers. In the present study, biological samples (blood and scalp hair) of male subjects having lung and bladder cancers and non-cancerous subjects belonging to arsenic (As)-exposed area of southern parts of Pakistan were analysed for As contents. The As levels in drinking water of understudy area showed that sections of understudy population are exposed to arsenic concentrations, which was 3–15-fold higher than the permissible level (<10 μg/L). For comparative purposes the biological samples of matched male cancer patient, as referent patients belonging to big city (Hyderabad) who had used municipal treated water with low arsenic levels <10 μg/L, were also collected. The exposed cancer patients have 2–3-fold higher level of As in both biological samples compared to non-exposed case-matched cancerous male subjects. This study is compelling evidence in support of positive associations between arsenic-contaminated water, food and cigarette with different types of risks of cancer.

scholarly journals Reproductive and developmental health effects of prenatal exposure to tetrachloroethylene-contaminated drinking water

2020 ◽  
Vol 22 (3) ◽  
pp. 555-566
Author(s):  
Ann Aschengrau ◽  
Michael R. Winter ◽  
Lisa G. Gallagher ◽  
Veronica M. Vieira ◽  
Lindsey J. Butler ◽  
...  
Keyword(s):  
Drinking Water ◽  
Health Effects ◽  
Prenatal Exposure ◽  
Community Settings ◽  
Contaminated Drinking Water ◽  
Developmental Health

Tetrachloroethylene (PCE) is a common contaminant in both occupational and community settings.

scholarly journals Environmental Pollution Effects on Mortality in an Industrial and a Non-industrial Municipality, in Voiotia Prefecture, Greece

2017 ◽  
Vol 7 (1) ◽  
pp. 94
Author(s):  
Eirini Saranti-Papasaranti ◽  
Elena Riza ◽  
Konstantinos Hadjistavrou ◽  
Demosthenes Panagiotakos ◽  
Athena Linos ◽  
...  
Keyword(s):  
Air Pollution ◽  
Drinking Water ◽  
Environmental Pollution ◽  
Health Effects ◽  
Direct Method ◽  
Cerebrovascular Diseases ◽  
Pollution Effects ◽  
Adverse Health Effects ◽  
Contaminated Drinking Water ◽  
Rate Ratios

In the Oinofita region, there was strong evidence of air pollution and hexavalent chromium (Cr(VI))-contaminated drinking water due to the increased number of industries, in contrast to the closely-located region of Arachova, which served as a control. To examine the health effects of environmental pollution, we performed an ecological study to compare the all-cause and cause-specific mortality. We considered the registered citizens of both study areas during an 11-year period (1999-2009) and we used the direct method of standardization to calculate the age, gender and period standardized rates (ASRs) and the standardized rate ratios (SRRs), using the greater Prefecture of Voiotia as the standard population. Statistically significantly higher rates of all-cause mortality (SRR = 1.22, 95% confidence intervals (CI) 1.1-1.4), cardiovascular (SRR = 1.36, 95% CI 1.1-1.7) and cerebrovascular diseases (SRR = 2.93, 95% CI 1.8-4.8) were identified for Oinofita compared to Arachova. Furthermore, suggestive results were found for cardiopulmonary diseases among males (SRR = 1.52, 95% CI 1.0-2.4) and leukaemias (SRR = 4.65, 95% CI 0.9-25.3). Elevated SRRs, not statistically significant though, were also observed for respiratory diseases, all cancers and specific cancer sites (lip, oral cavity and pharynx, liver, stomach, pancreas, lung, prostate, colon and kidney and other genitourinary organs among females). Increased mortality rates in the Oinofita region support the hypothesis of adverse health effects association with air pollution and Cr(VI)-contaminated drinking water. Further studies are needed to determine if this association is causal and to establish preventive guidelines and public health recommendations.

Arsenic concentrations and speciation in Australian and imported rice and commercial rice products

2018 ◽  
Vol 15 (7) ◽  
pp. 387 ◽  
Author(s):  
William Maher ◽  
Elliott Duncan ◽  
Hayden Martin ◽  
Peter Snell ◽  
Frank Krikowa ◽  
...  
Keyword(s):  
Drinking Water ◽  
Young Children ◽  
Potential Risk ◽  
Environmental Chemistry ◽  
Inorganic Arsenic ◽  
Dimethylarsinic Acid ◽  
Polished Rice ◽  
Inorganic As ◽  
Contaminated Drinking Water ◽  
Infants And Young Children

Environmental contextIn countries where inhabitants are not exposed to arsenic-contaminated drinking water, food is the major source of potentially toxic inorganic arsenic. To complement the existing worldwide dataset on arsenic in rice, data are presented on Australian- and overseas-grown rice, and assessed in terms of possible risk. Only a diet comprising multiple serves of some rice products per day poses a potential risk to young children. AbstractArsenic concentrations and speciation measurements were determined for six varieties of Australian-grown rice (n = 130), imported rice (n = 53) and rice products (n = 56) from supermarkets. Total As, inorganic As and dimethylarsinic acid (DMA) concentrations in Australian rice ranged from 16 to 630 µg As kg−1 (mean ± s.d.: 220 ± 122 µg kg−1), 16 to 250 µg As kg−1 (92 ± 52 µg As kg−1) and <5 to 432 µg As kg−1 (125 ± 109 µg As kg−1), respectively. Total As, inorganic As and DMA concentrations in imported rice ranged between 31 and 376 µg As kg−1 (130 ± 98 µg kg−1), 17 and 198 µg As kg−1 (73 ± 40 µg As kg−1) and <5 and 327 µg As kg−1 (84 ± 92 µg As kg−1) respectively. Few samples exceeded the guidelines for inorganic As in polished rice. In rice products, total As, inorganic As and DMA concentrations ranged between 21 and 480 µg As kg−1 (160 ± 110 µg As kg−1), 20 and 255 µg As kg−1 (92 ± 78 µg As kg−1) and <5 and 340 µg As kg−1 (65 ± 69 µg As kg−1) respectively. Sixteen samples exceeded the 100 µg kg−1 maximum for inorganic As concentration in rice foods for infants and young children. Ingestion of multiple serves of some rice products poses a potential risk. Environmental chemistry gaps, on processes influencing As occurrence in rice, are discussed.

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