Facile Synthesis of β-Phenylethylamine Derivatives Related to Baclofen via Aziridine Ring Opening

1990 ◽  
Vol 43 (6) ◽  
pp. 1123 ◽  
Author(s):  
RD Allan ◽  
HW Tran
Keyword(s):  
Ring Opening ◽  
Receptor Agonist ◽  
Gabab Receptor ◽  
Facile Synthesis ◽  
Aziridine Ring ◽  
Simple Route ◽  
Nucleophilic Ring Opening

Nucleophilic ring opening of the protonated salt of 2-(4-chlorophenyl ) aziridine with substituted thiols provides a very simple route to β- phenylethylamine derivatives which are analogues of the GABAB receptor agonist baclofen and its antagonists phaclofen and saclofen.

Chiral aziridine ring opening: facile synthesis of (R)-mexiletine and (R)-phenoxybenzamine hydrochloride

2015 ◽  
Vol 56 (38) ◽  
pp. 5269-5271 ◽  
Author(s):  
N. Viswanadh ◽  
R. Velayudham ◽  
S. Jambu ◽  
M. Sasikumar ◽  
M. Muthukrishnan
Keyword(s):  
Ring Opening ◽  
Facile Synthesis ◽  
Aziridine Ring

Chemistry of Tetrathiomolybdate:  Aziridine Ring Opening Reactions and Facile Synthesis of Interesting Sulfur Heterocycles

2005 ◽  
Vol 127 (37) ◽  
pp. 12760-12761 ◽  
Author(s):  
Devarajulu Sureshkumar ◽  
Srinivasa Murthy Koutha ◽  
Srinivasan Chandrasekaran
Keyword(s):  
Ring Opening ◽  
Facile Synthesis ◽  
Aziridine Ring ◽  
Ring Opening Reactions ◽  
Sulfur Heterocycles

Facile Synthesis of Hydroxy-Substituted Thiacrown Ethers via Nucleophilic Ring Opening of Epoxides

Synthesis ◽  
2019 ◽  
Vol 51 (10) ◽  
pp. 2214-2220 ◽  
Author(s):  
Monika Stefaniak ◽  
Jarosław Romański
Keyword(s):  
Click Chemistry ◽  
Ring Opening ◽  
Facile Synthesis ◽  
Step Procedure ◽  
Ring Opening Of Epoxides ◽  
One Step ◽  
Thiacrown Ethers ◽  
Hydroxy Groups ◽  
First Time ◽  
Nucleophilic Ring Opening

The title thiacrown ethers were prepared in a one-step procedure to give a series of unique macrocycles possessing two unsubstituted hydroxy groups that can be easily functionalized. In addition, epoxides and macrocycles derived from Cookson’s birdcage diketone, were prepared. The nucleophilic ring opening of epoxides synthesis can be classified in the frame of click chemistry. Surprisingly, some of the prepared allyl substituted polyglycols as well as bis-epoxides, especially sulfur analogues, were prepared for the first time.

scholarly journals Synthesis of 3,3-Diaryl/Heteroarylpropylamines via Nucleophilic Ring Opening of Activated Azetidines with Arenes and Heteroarenes: New Synthetic Route to (±)Tolterodine

ACS Omega ◽  
2018 ◽  
Vol 3 (12) ◽  
pp. 17562-17572 ◽  
Author(s):  
Gaurav Goswami ◽  
Navya Chauhan ◽  
Abhijit Mal ◽  
Subhomoy Das ◽  
Mowpriya Das ◽  
...  
Keyword(s):  
Ring Opening ◽  
Synthetic Route ◽  
Nucleophilic Ring Opening

scholarly journals Intramolecular N–Me and N–H aminoetherification for the synthesis of N-unprotected 3-amino-O-heterocycles

2021 ◽  
Author(s):  
Mahesh P. Paudyal ◽  
Mingliang Wang ◽  
Juha H. Siitonen ◽  
Yimin Hu ◽  
Muhammed Yousufuddin ◽  
...  
Keyword(s):  
Ring Opening ◽  
Domino Reaction ◽  
Aziridine Ring

A mild Rh-catalyzed method for synthesis of cyclic unprotected N–Me and N–H 2,3-aminoethers using an olefin aziridination–aziridine ring-opening domino reaction has been developed.

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