Metal template reactions. XVI. Design and synthesis of primary diamine ligands with additional nitrogen donor atoms

1983 ◽  
Vol 36 (6) ◽  
pp. 1141 ◽  
Author(s):  
DSC Black ◽  
NE Rothnie
Keyword(s):  
Metal Chelation ◽  
Design And Synthesis ◽  
Nitrogen Donor ◽  
Diamine Ligands ◽  
Additional Nitrogen

Five new primary diamines (8), (10), (12), (20) and (22) have been synthesized. These compounds contain additional nitrogen donor atoms suitable for metal chelation. An improved preparation of the triamine (6) is also reported.

Metal template reactions. XIX. Macrocyclic metal complexes derived from 2,2'-iminobisbenzaldehyde and some primary diamines with additional nitrogen donor atoms

1983 ◽  
Vol 36 (12) ◽  
pp. 2395 ◽  
Author(s):  
DSC Black ◽  
NE Rothnie
Keyword(s):  
Metal Complexes ◽  
Metal Salt ◽  
Macrocyclic Complexes ◽  
Nitrogen Donor ◽  
Additional Nitrogen ◽  
Macrocyclic Nickel

Macrocyclic nickel(II), copper(II) and cobalt(II) complexes (6), (7), (9), (11), (13), (17) and (19) have been prepared from 2,2'-iminobisbenzaldehyde, the appropriate metal salt and the primary diamines 3,3'-iminobispropylamine (4), 2,2'iminobisethylamine (9, 2,2'-(iminodimethylene)bisaniline (8), azobenzene-2,2'-diamine (10), 2,2'-iminobisaniline (12), 2-amino-N-(2'-aminophenyl)benzamide (16) and 2-amino-N-(2'-aminobenzoyl)benzamide (18) respectively. The nickel(II) complex (15), zinc(11) complex (21) and copper(II) complex (22) were also prepared by similar methods. 2,2'-(Benzene- 1,2-diyldiimino)bisbenzaldehyde (25) was prepared but did not undergo metal template reactions to allow the formation of macrocyclic complexes.

New Multidentate Pyrazolyl - Pyridine Ligands—Synthesis and Structures

2003 ◽  
Vol 56 (7) ◽  
pp. 665 ◽  
Author(s):  
Zöe R. Bell ◽  
Jon A. McCleverty ◽  
Michael D. Ward
Keyword(s):  
Crystal Structures ◽  
Multidentate Ligands ◽  
Pyridyl Group ◽  
X Ray ◽  
Pyridine Ligands ◽  
Nitrogen Donor ◽  
Methyl Naphthalene ◽  
Methyl Benzene ◽  
Additional Nitrogen ◽  
Methyl Pyridine

Five new multidentate ligands have been prepared containing N,N-bidentate pyrazolyl–pyridine units linked to a central aromatic spacer unit. The ligands 3,3′-bis(3-{pyridin-2-yl}-pyrazol-1-yl-methyl)-p-terphenyl (1), 4,4′-bis(3-{pyridin-2-yl}-pyrazol-1-yl)biphenyl (2), and 1,8-bis(3-{pyridin-2-yl}-pyrazol-1-yl-methyl)naphthalene (3) have two bidentate arms and are therefore potentially tetradentate; 2,6-bis(3-{pyridin-2-yl}-pyrazol-1-yl-methyl)pyridine (4) has two bidentate arms with an additional nitrogen-donor in the aromatic spacer unit (a pyridyl group) and is therefore potentially pentadentate; and 1,3,5-trimethyl-2,4,6-tris(3-{pyridin-2-yl}-pyrazol-1-yl-methyl)benzene (5) has three bidentate arms and is therefore potentially hexadentate. The X-ray crystal structures of all of these ligands have been determined.

Metal template reactions. XX. Macrocyclic metal complexes derived from 4,6-Dimethoxy-3-methylindole-2,7-dicarbaldehyde and some primary diamines with additional nitrogen donor atoms

1983 ◽  
Vol 36 (12) ◽  
pp. 2407 ◽  
Author(s):  
DSC Black ◽  
NE Rothnie ◽  
LCH Wong
Keyword(s):  
Metal Complexes ◽  
Hydride Reduction ◽  
Nitrogen Donor ◽  
Additional Nitrogen ◽  
Macrocyclic Nickel

4,6-Dimethoxy-3-methylindole-2,7-dicarbaldehyde (6) has been prepared by the formylation of 4,6-dimethoxy-3-methylindole (5)itself prepared by the hydride reduction of the oxoindole (4). Macrocyclic nickel(II) and copper(II) complexes (8), (10) and (12) have been prepared from the dialdehyde (6), the appropriate metal(II) acetate and the primary diamines 2,2'-iminobisaniline (7), 2-amino-N-(2'-aminophenyl)benzamide (9) and 2-amino-N-(2'-aminobenzoyl)benzamide (11) respectively.

Metal template reactions. XVIII. Macrocyclic metal complexes derived from 2,6-diacetylpyridine and some primary diamines with additional nitrogen donor atoms

1983 ◽  
Vol 36 (12) ◽  
pp. 2387 ◽  
Author(s):  
DSC Black ◽  
NE Rothnie
Keyword(s):  
Metal Complexes ◽  
Metal Salt ◽  
Macrocyclic Ligands ◽  
Nitrogen Donor ◽  
Additional Nitrogen ◽  
Macrocyclic Nickel

Macrocyclic nickel(II), copper(II) and cobalt(II) complexes (6), (8), (10), (12) and (14) have been prepared from 2,6-diacetylpyridine, the appropriate metal salt and the primary diamines 2,2'-(iminodimethylene)bisaniline (5), azobenzene-2,2'-diamine (7), 2,2'-iminobisaniline (9), 2-amino- N-(2'-aminopheny1)benzamide (11) and 2-amino-N-(2'-aminobenzoy1)benzamide (13) respectively. The primary diamines 2,2'-diaminooxanilide (15) and N,N'-(2'-phenylene)bis(2'-aminobenzamide) (16) could not be incorporated into macrocyclic ligands by similar techniques.

Prostatic Acid Phosphatase (PAP) Differentiated Ultracytochemically from Lysosomal Acid Phosphate in the Rat with a PAP/Specific Substrate, Phosphorylcholine

1975 ◽  
Vol 33 ◽  
pp. 450-451
Author(s):  
W. Allen Shannon ◽  
José A. Serrano ◽  
Hannah L. Wasserkrug ◽  
Anna A. Serrano ◽  
Arnold M. Seligman
Keyword(s):  
Acid Phosphatase ◽  
Phosphate Buffer ◽  
Prostatic Carcinoma ◽  
Prostatic Acid Phosphatase ◽  
Chemotherapeutic Agents ◽  
Specific Substrate ◽  
Acid Phosphate ◽  
Lysosomal Acid ◽  
Design And Synthesis ◽  
New Chemotherapeutic Agents

During the design and synthesis of new chemotherapeutic agents for prostatic carcinoma based on phosphorylated agents which might be enzyme-activated to cytotoxicity, phosphorylcholine, [(CH3)3+NCH2CH2OPO3Ca]Cl-, has been indicated to be a very specific substrate for prostatic acid phosphatase (PAP). This phenomenon has led to the development of specific histochemical and ultracytochemical methods for PAP using modifications of the Gomori lead method for acid phosphatase. Comparative histochemical results in prostate and kidney of the rat have been published earlier with phosphorylcholine (PC) and β-glycerophosphate (βGP). We now report the ultracytochemical results.Minced tissues were fixed in 3% glutaraldehyde-0.1 M phosphate buffered (pH 7.4) for 1.5 hr and rinsed overnight in several changes of 0.05 M phosphate buffer (pH 7.0) containing 7.5% sucrose. Tissues were incubated 30 min to 2 hr in Gomori acid phosphatase medium (2) containing 0.1 M substrate, either PC or βGP.

Tailoring microstructures of materials through biomimetics

1993 ◽  
Vol 51 ◽  
pp. 500-501
Author(s):  
Mehmet Sarikaya ◽  
Ilhan A. Aksay
Keyword(s):  
Chemical Properties ◽  
Design And Synthesis ◽  
Structure Sensitive ◽  
Macro Scale ◽  
Methods Of Synthesis ◽  
Successive Level ◽  
Engineering Materials ◽  
Physical And Chemical ◽  
And Chemical Properties ◽  
Synthesis Of Materials

Biomimetics involves investigation of structure, function, and methods of synthesis of biological composite materials. The goal is to apply this information to the design and synthesis of materials for engineering applications.Properties of engineering materials are structure sensitive through the whole spectrum of dimensions from nanometer to macro scale. The goal in designing and processing of technological materials, therefore, is to control microstructural evolution at each of these dimensions so as to achieve predictable physical and chemical properties. Control at each successive level of dimension, however, is a major challenge as is the retention of integrity between successive levels. Engineering materials are rarely fabricated to achieve more than a few of the desired properties and the synthesis techniques usually involve high temperature or low pressure conditions that are energy inefficient and environmentally damaging.In contrast to human-made materials, organisms synthesize composites whose intricate structures are more controlled at each scale and hierarchical order.

Design and synthesis of azaisoflavones

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
B Kang ◽  
YJ Jung ◽  
R Jeon
Keyword(s):  
Design And Synthesis
Sign in / Sign up

Export Citation Format

Share Document