Mass spectral and 13C N.M.R. analyses of aminoglycoside aminocyclitols modified by enzyme-catalysed reactions

1981 ◽  
Vol 34 (3) ◽  
pp. 547 ◽  
Author(s):  
RG Coombe ◽  
AM George
Keyword(s):  
Mass Spectrometry ◽  
Reaction Mechanisms ◽  
Analytical Methods ◽  
Mass Spectral ◽  
Enzymic Reaction

Chemical and physical analytical methods, including mass spectrometry and 13C n.m.r., have been applied to the evaluation of the structures of the inactivated products of enzyme-mediated transferase reactions. Evidence is presented for the assignment of structures for the products of three enzymic reaction mechanisms: O-adenylylation, O-phosphorylation and N-acetylation.

A Review of Analytical Methods for the Determination of Tibolone: Pharmacokinetics and Pharmaceutical Formulations Analysis and Application in Doping Control

2020 ◽  
Vol 17 (1) ◽  
pp. 31-39
Author(s):  
Marilene Lopes Ângelo ◽  
Fernanda de Lima Moreira ◽  
Ana Laura Araújo Santos ◽  
Hérida Regina Nunes Salgado ◽  
Magali Benjamim de Araújo
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Analytical Methods ◽  
Estrogenic Activity ◽  
Biological Fluids ◽  
Pharmaceutical Formulations ◽  
Doping Control ◽  
Specific Effects ◽  
In Doping

Background:: Tibolone is a synthetic steroid commercialized by Organon under the brand name Livial (Org OD14), which is used in hormone therapy for menopause management and treatment of postmenopausal osteoporosis. Tibolone is defined as a selective tissue estrogenic activity regulator (STEAR) demonstrating tissue-specific effects on several organs such as brain, breast, urogenital tract, endometrium, bone and cardiovascular system. Aims:: This work aims to (1) present an overview of important published literature on existing methods for the analysis of tibolone and/or its metabolites in pharmaceutical formulations and biological fluids and (2) to conduct a critical comparison of the analytical methods used in doping control, pharmacokinetics and pharmaceutical formulations analysis of tibolone and its metabolites. Results and conclusions: : The major analytical method described for the analysis of tibolone in pharmaceutical formulations is High Pressure Liquid Chromatography (HPLC) coupled with ultraviolet (UV) detection, while Liquid Chromatography (LC) or Gas Chromatography (GC) used in combination with Mass Spectrometry (MS) or tandem mass spectrometry (MS/MS) is employed for the analysis of tibolone and/or its metabolites in biological fluids.

scholarly journals Mass spectral and theoretical investigations of the transient proton-bound dimers on the cleavage processes of the peptide GHK and its analogues

RSC Advances ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 4077-4086
Author(s):  
Jinhu Wang ◽  
Cheng Wang ◽  
Han Zhang ◽  
Yang Liu ◽  
Tiesheng Shi
Keyword(s):  
Mass Spectrometry ◽  
Theoretical Calculations ◽  
Mass Spectral ◽  
Protonated Peptides ◽  
Fragmentation Mechanisms ◽  
Theoretical Investigations

Fragmentation mechanisms of the singly protonated peptides GHK, GHKH and HGHK have been investigated by mass spectrometry and theoretical calculations.

scholarly journals Multi-residue analytical methods for the determination of pesticides and PPCPs in water by LC-MS/MS: a review

2012 ◽  
Vol 10 (3) ◽  
pp. 876-899 ◽  
Author(s):  
Ednei Primel ◽  
Sergiane Caldas ◽  
Ana Escarrone
Keyword(s):  
Mass Spectrometry ◽  
Analytical Methods ◽  
Environmental Samples ◽  
World Wide ◽  
Matrix Effects ◽  
Tandem Mass ◽  
Selective Determination ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass

AbstractResidues of pesticides, pharmaceutical and personal care products (PPCPs) are contaminants of world-wide concern. Consequently, there is a growing need to develop reliable analytical methods, which enable rapid, sensitive and selective determination of these pollutants in environmental samples, at trace levels. In this paper, a review of the liquid chromatography-tandem mass spectrometry (LC-MS/MS) based methods for the determination of pesticides and PPCPs in the environment is presented. Advanced aspects of current LC-MS/MS methodology, including sample preparation and matrix effects, are discussed.

Developments in mycotoxin analysis: an update for 2015-2016

2017 ◽  
Vol 10 (1) ◽  
pp. 5-29 ◽  
Author(s):  
F. Berthiller ◽  
C. Brera ◽  
M.H. Iha ◽  
R. Krska ◽  
V.M.T. Lattanzio ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Critical Review ◽  
Analytical Methods ◽  
Ergot Alkaloids ◽  
Sampling Strategies ◽  
Liquid Chromatography Mass Spectrometry ◽  
Recent Developments ◽  
Mycotoxin Analysis

This review summarises developments in the determination of mycotoxins over a period between mid-2015 and mid-2016. Analytical methods to determine aflatoxins, Alternaria toxins, ergot alkaloids, fumonisins, ochratoxins, patulin, trichothecenes and zearalenone are covered in individual sections. Advances in proper sampling strategies are discussed in a dedicated section, as are methods used to analyse botanicals and spices and newly developed liquid chromatography mass spectrometry based multi-mycotoxin methods. This critical review aims to briefly discuss the most important recent developments and trends in mycotoxin determination as well as to address limitations of presented methodologies.

scholarly journals Desorption/Ionization Fluence Thresholds and Improved Mass Spectral Consistency Measured Using a Flattop Laser Profile in the Bioaerosol Mass Spectrometry of SingleBacillusEndospores

2005 ◽  
Vol 77 (22) ◽  
pp. 7448-7454 ◽  
Author(s):  
Paul T. Steele ◽  
Abneesh Srivastava ◽  
Maurice E. Pitesky ◽  
David P. Fergenson ◽  
Herbert J. Tobias ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Mass Spectral ◽  
Desorption Ionization ◽  
Bioaerosol Mass Spectrometry ◽  
Laser Profile
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