The synthesis and kinetics of isomerization and solvent exchange of the trans-Chloro(dimethyl sulfoxide)bis(ethylenediamine)cobalt(III) ion in dimethyl sulfoxide

1981 ◽  
Vol 34 (1) ◽  
pp. 215 ◽  
Author(s):  
WG Jackson
Keyword(s):  
Exchange Rate ◽  
Dimethyl Sulfoxide ◽  
Synthesis And Characterization ◽  
Aqueous Systems ◽  
Solvent Exchange ◽  
Kinetics Of ◽  
Cis Isomer

The synthesis and characterization of trans-[CO(en)2(Me2SO)Cl](ClO4)2 are described. Its rate of isomerization to the cis isomer has been measured in Me2SO in the range 293-313 K: ktc = 1.54 × 10-3s-1 at 298.2 K, ΔH‡ = 105 kJ mol-1, ΔS‡ = 55 J mol-1 K-1. The solvent exchange rate has been measured by 1H n.m.r. spectroscopy in (CD3)2SO at 308.2K: kex = ktt+ktc = 7.0xl0-3 s-1. These and other data show that trans-to-cis isomerization requires solvent exchange, each act of which leads to substantial rearrangement, c. 90% cis (308.2 K). Differences between non-aqueous and aqueous systems in the steric course of substitution are discussed.

scholarly journals cis-Tetrachlorido-bis(indazole)osmium(iv) and its osmium(iii) analogues: paving the way towards the cis-isomer of the ruthenium anticancer drugs KP1019 and/or NKP1339

2017 ◽  
Vol 46 (35) ◽  
pp. 11925-11941 ◽  
Author(s):  
Gabriel E. Büchel ◽  
Susanne Kossatz ◽  
Ahmad Sadique ◽  
Peter Rapta ◽  
Michal Zalibera ◽  
...  
Keyword(s):  
Anticancer Drugs ◽  
Synthesis And Characterization ◽  
Cis Isomer ◽  
The Way

The synthesis and characterization of cis-[OsIVCl4(κN2-1H-indazole)2] and its 1e-reduced analog are reported.

scholarly journals Synthesis and Characterization of Gellan Gum-Pyridoxine Nanoparticle for Treatment of Localized Peripheral Neuropathy

2019 ◽  
Vol 9 (1S4) ◽  
pp. 576-580
Keyword(s):  
Antimicrobial Activity ◽  
Peripheral Neuropathy ◽  
Release Kinetics ◽  
Drug Carrier ◽  
Gellan Gum ◽  
Synthesis And Characterization ◽  
Antioxidant Assay ◽  
Gram Positive Bacteria ◽  
Kinetics Of

Biopolymer has full application as a drug carrier and scaffold in tissue engineering because of its biodegradability and non-toxicity. The present study is focused on novel biopolymer gellan gum as a drug delivery agent. The objective of the study is to synthesize the gellan gum nanoparticle by solvent evaporation emulsification method and characterize it using SEM, DLS, FTIR, and XRD. As pyridoxine is effectively used to treat diabetic peripheral neuropathy, it has been encapsulated with gellan gum and characterized. The antioxidant assay was performed using ABTS reagent, and the activity increases with increasing concentration of nanoparticle. Also, it has significant antimicrobial activity against gram-positive bacteria. Apart from this, the drug release kinetics of the gellan gum- pyridoxine nanoparticle was studied.

scholarly journals Synthesis and Characterization of Erythromycin Loaded PLGA and PCL Microspheres: Antimicrobial Application

2021 ◽  
Author(s):  
Lamia Bennabi ◽  
Ilham Abedelemalek ◽  
Abedelkader Ammari ◽  
Khaldia Sediri ◽  
Fatima Bennabi ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Glycolic Acid ◽  
Release Kinetics ◽  
Synthesis And Characterization ◽  
X Ray Diffraction ◽  
X Ray ◽  
Complementary Effect ◽  
Kinetics Of ◽  
Scanning Electron

Abstract We presents in this work the preparation of several formulations, based on biocompatible biodegradable polymers: polycaprolactone (PCL) and poly(lactic-co-glycolic) acid (PLGA) loaded with Erythromycin (ERYT) antibiotic. These biocompatible materials were used to prepare microspheres with and without immobilized ERYT via simple evaporation method by simple emulsion. The particle size was determined by scanning electron microscopy and the absence of the interaction with ERYT was confirmed via X-ray diffraction and infrared spectroscopy. The release kinetics of ERYT were studied and then, ERYT loaded PCL and PLGA blends microspheres were used for the inhibition of gram-positive S. aureus strain. The microbial activity was carried-out by Agar diffusion disc method. The results show that PCL/PLGA blend and PCL alone inhibited the strain by ERYT present in kinetic aliquots with the complementary effect of the polymers. A numerical model was proposed for modeling the kinetics reported in our study.

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