Quinazolines. XXIV. The Synthesis of 2,4-Diazatetra-cyclo[7,3,1,17,11,01,6]tetradecanes(Adamantano [1,2-d]pyrimidines)

1979 ◽  
Vol 32 (8) ◽  
pp. 1805 ◽  
Author(s):  
WLF Armarego ◽  
PG Tucker
Keyword(s):  
Biological Evaluation ◽  
Adamantane Derivative ◽  
Carbonyl Chloride ◽  
Related Compounds

The syntheses of 6-hydroxy-2,4-Diazatetracyclo[7,3,1,17,11,01,6]tetradecan-3-iminium (4) picrate and related compounds starting from 2-oxoadamantane-1-carbonyl chloride (5) are described. In preliminary biological evaluation it was found that the most toxic (M.L.D. values for mice) adamantane derivative, 3,5 diazatetracyclo[7,3,1,17,11,01,6]tetradecane-2,4-dione (76 mg kg-1), was much less toxic than tetrodotoxin (0.013 mg kg-1).

ChemInform Abstract: Synthesis and Biological Evaluation of 4-(Hydroxyalkyl)estradiols and Related Compounds.

ChemInform ◽  
2010 ◽  
Vol 29 (8) ◽  
pp. no-no
Author(s):  
C. J. LOVELY ◽  
A. S. BHAT ◽  
H. D. COUGHENOUR ◽  
N. E. GILBERT ◽  
R. W. BRUEGGEMEIER
Keyword(s):  
Biological Evaluation ◽  
Synthesis And Biological Evaluation ◽  
Related Compounds

scholarly journals Organometallic Nucleosides: Synthesis and Biological Evaluation of Substituted Dicobalt Hexacarbonyl Alkynyl Modified 2′-Deoxyuridines

Proceedings ◽  
2019 ◽  
Vol 22 (1) ◽  
pp. 62
Author(s):  
Roman Dembinski ◽  
Renata Kaczmarek ◽  
Dariusz Korczyński ◽  
Karolina Królewska-Golińska
Keyword(s):  
Cell Line ◽  
K562 Cells ◽  
Biological Evaluation ◽  
Oxygen Species ◽  
K562 Cell Line ◽  
Dicobalt Octacarbonyl ◽  
Cobalt Compounds ◽  
Dicobalt Hexacarbonyl ◽  
Synthesis And Biological Evaluation ◽  
Related Compounds

In continuation of synthetic pursuit of metallo-nucleosides, in particular dicobalt hexacarbonyl 5-alkynyl-2′-deoxyuridines, novel compounds with alkynyl groups were synthesized, starting from 5-iodo-2′-deoxyuridine. Reactions of dicobalt octacarbonyl [Co2(CO)8] with 2′-deoxy-5-oxopropynyluridines and related compounds gave dicobalt hexacarbonyl nucleoside complexes (83–31%). The growth inhibition of HeLa and K562 cancer cell lines by organometallic nucleosides was examined and compared to that by alkynyl nucleoside precursors. Coordination of the dicobalt carbonyl moiety to the 2′-deoxy-5-alkynyluridines led to a significant increase in its cytotoxic potency. The cobalt compounds antiproliferative activities against the HeLa cell line and the K562 cell line will be described. Coordination of an acetyl-substituted cobalt nucleoside was expanded using the 1,1-bis(diphenylphosphino)methane (dppm) ligand, resulting in cytotoxicity at comparable levels. The formation of reactive oxygen species in the presence of cobalt compounds was determined in K562 cells. The results indicate that the mechanism of action for most antiproliferative cobalt compounds may be related to the induction of oxidative stress.

ChemInform Abstract: Efficient Synthesis and Biological Evaluation of Epiceanothic Acid and Related Compounds.

ChemInform ◽  
2011 ◽  
Vol 42 (20) ◽  
pp. no-no
Author(s):  
Pu Zhang ◽  
Li Xu ◽  
Keduo Qian ◽  
Jun Liu ◽  
Luyong Zhang ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Efficient Synthesis ◽  
Synthesis And Biological Evaluation ◽  
Related Compounds
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