New Insight into the Central Benzodiazepine Receptor–Ligand Interactions: Design, Synthesis, Biological Evaluation, and Molecular Modeling of 3-Substituted 6-Phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and Related Compounds

Maurizio Anzini; Salvatore Valenti; Carlo Braile; Andrea Cappelli; Salvatore Vomero; Stefano Alcaro; Francesco Ortuso; Luciana Marinelli; Vittorio Limongelli; Ettore Novellino; Laura Betti; Gino Giannaccini; Antonio Lucacchini; Simona Daniele; Claudia Martini; Carla Ghelardini; Lorenzo Di Cesare Mannelli; Gianluca Giorgi; Maria Paola Mascia; Giovanni Biggio

doi:10.1021/jm2001597

New Insight into the Central Benzodiazepine Receptor–Ligand Interactions: Design, Synthesis, Biological Evaluation, and Molecular Modeling of 3-Substituted 6-Phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and Related Compounds

Journal of Medicinal Chemistry ◽

10.1021/jm2001597 ◽

2011 ◽

Vol 54 (16) ◽

pp. 5694-5711 ◽

Cited By ~ 26

Author(s):

Maurizio Anzini ◽

Salvatore Valenti ◽

Carlo Braile ◽

Andrea Cappelli ◽

Salvatore Vomero ◽

...

Keyword(s):

Molecular Modeling ◽

Benzodiazepine Receptor ◽

Biological Evaluation ◽

Receptor Ligand ◽

Design Synthesis ◽

Ligand Interactions ◽

Central Benzodiazepine Receptor ◽

Related Compounds ◽

Insight Into

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Design, synthesis and biological evaluation of estradiol-PEG-linked platinum(II) hybrid molecules: Comparative molecular modeling study of three distinct families of hybrids

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10.1016/j.steroids.2010.09.004 ◽

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Vol 76 (1-2) ◽

pp. 94-103 ◽

Cited By ~ 28

Author(s):

Josée Provencher-Mandeville ◽

Chhanda Debnath ◽

Sanat K. Mandal ◽

Valérie Leblanc ◽

Sophie Parent ◽

...

Keyword(s):

Molecular Modeling ◽

Biological Evaluation ◽

Design Synthesis ◽

Molecular Modeling Study ◽

Hybrid Molecules ◽

Synthesis And Biological Evaluation ◽

Modeling Study

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Compounds from Danshen. Part 4. Structure-activity relationship of miltirone, an active central benzodiazepine receptor ligand isolated from Salvia miltiorrhiza Bunge (Danshen)

Journal of Medicinal Chemistry ◽

10.1021/jm00109a022 ◽

1991 ◽

Vol 34 (5) ◽

pp. 1675-1692 ◽

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Author(s):

Hson Mou Chang ◽

Kuk Ying Chui ◽

Fan Wah Lau Tan ◽

Yun Yang ◽

Zeng Pei Zhong ◽

...

Keyword(s):

Salvia Miltiorrhiza ◽

Benzodiazepine Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Salvia Miltiorrhiza Bunge ◽

Receptor Ligand ◽

Structure Activity ◽

Central Benzodiazepine Receptor ◽

Relationship Of

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Bioorganic Chemistry ◽

10.1016/j.bioorg.2018.09.001 ◽

2018 ◽

Vol 81 ◽

pp. 612-629 ◽

Cited By ~ 7

Author(s):

Mai Adel ◽

Rabah A.T. Serya ◽

Deena S. Lasheen ◽

Khaled A.M. Abouzid

Keyword(s):

Molecular Modeling ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Biological Evaluation ◽

Design Synthesis

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European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2018.01.073 ◽

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Vol 146 ◽

pp. 541-553 ◽

Cited By ~ 3

Author(s):

Zi-Sheng Kang ◽

Cong Wang ◽

Xiao-Lin Han ◽

Jun-Jie Du ◽

Yan-Yi Li ◽

...

Keyword(s):

Vitamin D ◽

Chronic Pancreatitis ◽

Vitamin D Receptor ◽

Biological Evaluation ◽

Side Chain ◽

Receptor Ligand ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Discovery of novel 5-methyl-1H -pyrazole derivatives as potential antiprostate cancer agents: Design, synthesis, molecular modeling, and biological evaluation

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10.1111/cbdd.13173 ◽

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Vol 91 (6) ◽

pp. 1113-1124 ◽

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Author(s):

Daoguang Zhang ◽

Solomon Asnake ◽

Jingya Zhang ◽

Per-Erik Olsson ◽

Guisen Zhao

Keyword(s):

Molecular Modeling ◽

Biological Evaluation ◽

Pyrazole Derivatives ◽

Design Synthesis

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Arylamide as Potential Selective Inhibitor for Matrix Metalloproteinase 9 (MMP9): Design, Synthesis, Biological Evaluation, and Molecular Modeling

Journal of Chemical Information and Modeling ◽

10.1021/acs.jcim.9b00630 ◽

2019 ◽

Vol 60 (1) ◽

pp. 349-359 ◽

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Author(s):

Maywan Hariono ◽

Rina F. Nuwarda ◽

Muhammad Yusuf ◽

Rollando Rollando ◽

Riris I. Jenie ◽

...

Keyword(s):

Molecular Modeling ◽

Matrix Metalloproteinase ◽

Biological Evaluation ◽

Selective Inhibitor ◽

Matrix Metalloproteinase 9 ◽

Design Synthesis ◽

Metalloproteinase 9

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Design, synthesis, biological evaluation and molecular modeling of novel 1H-pyrazolo[3,4-d]pyrimidine derivatives as BRAFV600E and VEGFR-2 dual inhibitors

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2018.05.054 ◽

2018 ◽

Vol 155 ◽

pp. 210-228 ◽

Cited By ~ 12

Author(s):

Yuanyuan Wang ◽

Shanhe Wan ◽

Zhonghuang Li ◽

Yu Fu ◽

Guangfa Wang ◽

...

Keyword(s):

Molecular Modeling ◽

Biological Evaluation ◽

Pyrimidine Derivatives ◽

Design Synthesis ◽

Dual Inhibitors

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NovelN-(Arylalkyl)indol-3-ylglyoxylylamides Targeted as Ligands of the Benzodiazepine Receptor: Synthesis, Biological Evaluation, and Molecular Modeling Analysis of the Structure−Activity Relationships†

Journal of Medicinal Chemistry ◽

10.1021/jm010827j ◽

2001 ◽

Vol 44 (14) ◽

pp. 2286-2297 ◽

Cited By ~ 15

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Giampaolo Primofiore ◽

Federico Da Settimo ◽

Sabrina Taliani ◽

Anna Maria Marini ◽

Ettore Novellino ◽

...

Keyword(s):

Molecular Modeling ◽

Benzodiazepine Receptor ◽

Biological Evaluation ◽

Structure Activity Relationships ◽

Structure Activity ◽

Modeling Analysis

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Design, synthesis, and biological evaluation of 1,2,3-trisubstituted-1,4-dihydrobenzo[g]quinoxaline-5,10-diones and related compounds as antifungal and antibacterial agents

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2006.04.029 ◽

2006 ◽

Vol 14 (17) ◽

pp. 6120-6126 ◽

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Dharmendra B. Yadav ◽

Hardesh K. Maurya ◽

Ashok K. Chaturvedi ◽

Praveen K. Shukla

Keyword(s):

Antibacterial Agents ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Related Compounds

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Design, synthesis, biological evaluation and molecular modeling of novel 2-amino-4-(1-phenylethoxy) pyridine derivatives as potential ROS1 inhibitors

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2017.11.002 ◽

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Vol 143 ◽

pp. 182-199 ◽

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Lifan Long ◽

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Keyword(s):

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Biological Evaluation ◽

Pyridine Derivatives ◽

Design Synthesis

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