Derivatives of orthoacids. IV. Acid-catalysed thermal eliminations and baseinduced eliminations of some 2-Ethoxy-1,3-dioxolans

1968 ◽  
Vol 21 (8) ◽  
pp. 2013 ◽  
Author(s):  
JS Josan ◽  
FW Eastwood
Keyword(s):  
Carbon Dioxide ◽  
Carboxylic Acid ◽  
Carbonyl Compound ◽  
Ethyl Formate ◽  
Preparative Method ◽  
Derivatives Of

A series of phenyl substituted 2-ethoxy-1,3-dioxolans (orthoformates) has been prepared and their stereochemistry assigned. When heated in the presence of a carboxylic acid they underwent a stereospecific cis elimination to form the corresponding olefins, carbon dioxide, and ethanol. Provided that one 4 or 5 position in these dioxolans was unsubstituted, they reacted with butyllithium through elimination of the elements of ethyl formate and the formation of a carbonyl compound. The eliminated portion was always converted by the butyllithium into nonan-5-ol. A simple preparative method for cis-stilbene is described.

Derivatives of orthoacids. II. The preparation of olefins from 1,2-diols

1964 ◽  
Vol 17 (12) ◽  
pp. 1392 ◽  
Author(s):  
G Crank ◽  
FW Eastwood
Keyword(s):  
Carbon Dioxide ◽  
Allyl Alcohol ◽  
Ethyl Formate ◽  
Diethyl Maleate ◽  
Compound I ◽  
Reaction Sequence ◽  
Ethyl Orthoformate ◽  
Derivatives Of

Ethyl orthoformate reacted with pinacol to form 2-ethoxy-4,4,5,5-tetramethyl-1,3-dioxolan (I) which decomposed on heating to yield ethanol, carbon dioxide, and 2,3-dimethylbut-2-ene. When subjected to the same reaction sequence diethyl- D-tartrate, diethyl-meso-tartrate, meso-1,2-diphenylethane-1,2-diol, and cis-cyclo-hexane-1,2-dial underwent specific cis-elimination to yield diethyl fumarate, diethyl maleate, cis-stilbene, and cyclohexane respectively. Glycerol, butane-1,2,4-trial, and pentane-1,2,5-triol formed polymers which decomposed to yield allyl alcohol, but-1-en-4-ol, and pent-1-en-5-ol respectively. Pyrolysis of the monoformyl esters of cis-cyclohexane-1,2-diol, glycerol, butane-1,2,4-triol, and pentane-l,2,5-trio1 gave the respective products enumerated above whereas the monoformyl ester of pinacol yielded pinacolone. When compound (I) was heated in the presence of p-toluenesulphonic acid it gave ethyl formate, pinacolone, 2,3-dimethylbutadiene, and water.

scholarly journals Novel Derivatives of 4-Methyl-1,2,3-Thiadiazole-5-Carboxylic Acid Hydrazide: Synthesis, Lipophilicity, and In Vitro Antimicrobial Activity Screening

2021 ◽  
Vol 11 (3) ◽  
pp. 1180
Author(s):  
Kinga Paruch ◽  
Łukasz Popiołek ◽  
Anna Biernasiuk ◽  
Anna Berecka-Rycerz ◽  
Anna Malm ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Carboxylic Acid ◽  
Bacterial Infections ◽  
Acid Hydrazide ◽  
Antimicrobial Effect ◽  
In Vitro Antimicrobial Activity ◽  
Research Goal ◽  
New Compounds ◽  
Derivatives Of

Bacterial infections, especially those caused by strains resistant to commonly used antibiotics and chemotherapeutics, are still a current threat to public health. Therefore, the search for new molecules with potential antimicrobial activity is an important research goal. In this article, we present the synthesis and evaluation of the in vitro antimicrobial activity of a series of 15 new derivatives of 4-methyl-1,2,3-thiadiazole-5-carboxylic acid. The potential antimicrobial effect of the new compounds was observed mainly against Gram-positive bacteria. Compound 15, with the 5-nitro-2-furoyl moiety, showed the highest bioactivity: minimum inhibitory concentration (MIC) = 1.95–15.62 µg/mL and minimum bactericidal concentration (MBC)/MIC = 1–4 µg/mL.

Field evaluation of vaporised ethyl formate and carbon dioxide for fumigation of stored wheat

2009 ◽  
Vol 66 (4) ◽  
pp. 417-424 ◽  
Author(s):  
Greg Dojchinov ◽  
Katherine A Damcevski ◽  
James D Woodman ◽  
Victoria S Haritos
Keyword(s):  
Carbon Dioxide ◽  
Field Evaluation ◽  
Ethyl Formate ◽  
Stored Wheat

Some Basic Derivatives of 3-Methylflavone-8-carboxylic Acid

1960 ◽  
Vol 2 (3) ◽  
pp. 263-269 ◽  
Author(s):  
Paolo Da Re ◽  
Lucia Verlicchi ◽  
Ivo Setnikar
Keyword(s):  
Carboxylic Acid ◽  
Derivatives Of

scholarly journals Hyperbranched Molecular Structures with Potential Antiviral Activity: Derivatives of 5,6-Dihydroxyindole-2-Carboxylic Acid

Molecules ◽  
2006 ◽  
Vol 11 (12) ◽  
pp. 968-977 ◽  
Author(s):  
Mario Sechi ◽  
Fabio Casu ◽  
Ilaria Campesi ◽  
Stefano Fiori ◽  
Alberto Mariani
Keyword(s):  
Carboxylic Acid ◽  
Antiviral Activity ◽  
Molecular Structures ◽  
Derivatives Of

Heterocycles from 2-Aminopyridine and Derivatives of 3-Methylbenzofuran-2-carboxylic Acid

Heterocycles ◽  
1997 ◽  
Vol 45 (4) ◽  
pp. 787 ◽  
Author(s):  
Yvette A. Jackson ◽  
Mark F. Williams
Keyword(s):  
Carboxylic Acid ◽  
Derivatives Of

Aminoalkyl derivatives of 2,4′-bithiazole-4-carboxylic acid, the intercalating part of bleomycin

1984 ◽  
Vol 21 (3) ◽  
pp. 681-683 ◽  
Author(s):  
Raymond Houssin ◽  
Jean-Luc Bernier ◽  
Jean-Pierre Hénichart
Keyword(s):  
Carboxylic Acid ◽  
Derivatives Of
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