Pyrimidine reactions. XVI. Thermal rearrangement of substituted 2- and 4-alkoxypyrimidines

1968 ◽  
Vol 21 (1) ◽  
pp. 243 ◽  
Author(s):  
DJ Brown ◽  
T Lee
Keyword(s):  
Electronic Effect ◽  
Thermal Rearrangement ◽  
Ultraviolet Spectra ◽  
Pka Value ◽  
Nitro Derivatives ◽  
Methyl Derivatives ◽  
Spectral Comparison ◽  
Derivatives Of ◽  
Methyl Bromo

Thermal rearrangement of methyl, bromo, and nitro derivatives of 2- and 4-alkoxy-pyrimidines produced their N-alkyl isomers. These were identified by p.m.r. spectral comparison with synthetic specimens of unambiguous or proven structure. The rates for such isomerizations were measured conveniently by changes in ultraviolet spectra. The C-methyl derivatives rearranged more slowly than the parent alkoxypyrimidines, but the bromo, and especially the nitro, derivatives did so much more quickly. Among the derivatives of each methoxy-pyrimidine, the rate of rearrangement increased as the basic pKa value fell and as the methoxyl protons moved downfield, thus affording a qualitative correlation with properties reflecting the electronic effect of each substituent.

ChemInform Abstract: ELECTRONIC EFFECT IN THE RADICAL DIANIONS OF THE NITRO DERIVATIVES OF 2-PHENYLBENZIMIDAZOLE

1979 ◽  
Vol 10 (36) ◽  
Author(s):  
I. M. SOSONKIN ◽  
G. N. STROGOV ◽  
V. K. SHCHEL'TSYN ◽  
N. V. FEDYAINOV
Keyword(s):  
Electronic Effect ◽  
Nitro Derivatives ◽  
Derivatives Of

Thio derivatives of β-diketones and their metal chelates. VII. The visible-ultraviolet spectra of some monothio-b-diketones and their metal chelates

1967 ◽  
Vol 20 (6) ◽  
pp. 1079 ◽  
Author(s):  
SHH Chaston ◽  
SE Livingstone
Keyword(s):  
Oxygen Atom ◽  
Electronic Spectra ◽  
Metal Chelates ◽  
Sulphur Atom ◽  
Cadmium Complexes ◽  
Ultraviolet Spectra ◽  
Mercury Complex ◽  
Methyl Derivatives ◽  
Derivatives Of

The electronic spectra of 3-mercapto-1,3-diphenylprop-2-en-1-one, PhC(SH)=CHCOPh, and its zinc(II), silver(I), cadmium(II), mercury(II), and S-methyl derivatives are given and some provisional assignments of the bands are made. The spectra indicate that the oxygen atom of the ligand is weakly coordinated in the silver and cadmium complexes and that in the mercury complex the ligand is coordinated through the sulphur atom only. The spectra of two other monothio-β-diketones, R1C(SH)=CHCOR2 (R1 = R2 = Me, But), are also given. The spectra of the nickel(II) chelates of seven monothio-β- diketones are discussed and the bands are assigned as metal d-d, metal- to-ligand, ligand-to-metal, and ligand-to-ligand transitions.

A synthesis of acronycine

1970 ◽  
Vol 23 (9) ◽  
pp. 1881 ◽  
Author(s):  
J Hlubucek ◽  
E Ritchie ◽  
WC Taylor
Keyword(s):  
Thermal Rearrangement ◽  
Methyl Derivatives ◽  
Derivatives Of

Improved syntheses of certain O-and N-methyl derivatives of 1,3-dihydroxy-acridone are described. Thermal rearrangement of the appropriate 3-α,α-dimethyl-propargyl ethers in the series yields products which may be methylated to acronycine.

Physical Properties of TCNQ Salts with N-Methyl Derivatives of Pyridine

1982 ◽  
Vol 85 (1) ◽  
pp. 257-263 ◽  
Author(s):  
A. Graja ◽  
M. Przybylski ◽  
B. Butka ◽  
R. Swietlik
Keyword(s):  
Physical Properties ◽  
Methyl Derivatives ◽  
Derivatives Of

QSAR Analysis of Selected Antimicrobial Structures Belonging to Nitro-derivatives of Heterocyclic Compounds

2020 ◽  
Vol 17 (2) ◽  
pp. 214-225 ◽  
Author(s):  
Piotr Kawczak ◽  
Leszek Bober ◽  
Tomasz Bączek
Keyword(s):  
Antimicrobial Activity ◽  
Heterocyclic Compounds ◽  
Molecular Descriptors ◽  
Microbiological Activity ◽  
Activity Data ◽  
Qsar Analysis ◽  
Qsar Models ◽  
Nitro Derivatives ◽  
Semi Empirical ◽  
Derivatives Of

Background: Nitro-derivatives of heterocyclic compounds were used as active agents against pathogenic microorganisms. A set of 4- and 5-nitroimidazole derivatives exhibiting antimicrobial activity was analyzed with the use of Quantitative Structure-Activity Relationships (QSAR) method. The study included compounds used both in documented treatment and those described as experimental. Objective: The purpose of this study was to demonstrate the common and differentiating characteristics of the above-mentioned chemical compounds alike physicochemically as well as pharmacologically based on the quantum chemical calculations and microbiological activity data. Methods: During the study PCA and MLR analysis were performed, as the types of proposed chemometric approach. The semi-empirical and ab initio level of in silico molecular modeling was performed for calculations of molecular descriptors. Results: QSAR models were proposed based on chosen descriptors. The relationship between the nitro-derivatives structure and microbiological activity data was able to class and describe the antimicrobial activity with the use of statistically significant molecular descriptors. Conclusion: The applied chemometric approaches revealed the influential features of the tested structures responsible for the antimicrobial activity of studied nitro-derivatives.

Methyl derivatives of furan

1974 ◽  
Vol 39 (11) ◽  
pp. 3109-3116 ◽  
Author(s):  
J. Šrogl ◽  
M. Janda ◽  
I. Stibor ◽  
V. Skála ◽  
P. Trška ◽  
...  
Keyword(s):  
Methyl Derivatives ◽  
Derivatives Of

Electrochemical reduction of para-substituted 2-acyl-5-phenylfuranes in dimethylformamide

1981 ◽  
Vol 46 (2) ◽  
pp. 498-502 ◽  
Author(s):  
Jozef Černák ◽  
František Tomanovič ◽  
Andrej Staško ◽  
Anna Fedosyevna Oleinikova ◽  
Jaroslav Kováč
Keyword(s):  
Electrochemical Reduction ◽  
Unpaired Electron ◽  
Anion Radical ◽  
Electron Wave ◽  
Epr Method ◽  
Electron Center ◽  
Nitrogen Nucleus ◽  
Nitro Derivatives ◽  
Stable Anion ◽  
Derivatives Of

para Substituted chloro, bromo, and nitro derivatives of 2-acyl-5-phenylfurane are reduced polarographically in a one-electron wave to the corresponding anion radicals, which were studied by the EPR method. The reduction of nitro derivatives, studied by the Kalousek switch, is reversible and leads to a stable anion radical with an unpaired electron center on the nitrogen nucleus; the reduction of the halogen derivatives is only partly reversible and leads to unstable ketyl radicals. The bromo derivatives give polarographic maxima typical for concurrent reactions.

O'-Methyl derivatives of arabinosylcytosine

1972 ◽  
Vol 46 (4) ◽  
pp. 1734-1741 ◽  
Author(s):  
E. Darżynkiewicz ◽  
J.T. Kuśmierek ◽  
D. Shugar
Keyword(s):  
Methyl Derivatives ◽  
Derivatives Of
Sign in / Sign up

Export Citation Format

Share Document