scholarly journals Evaluation of a Continuous-Flow Photo-Bromination Using N-Bromosuccinimide for Use in Chemical Manufacture

2021 ◽  
Author(s):  
Matthew Waterford ◽  
Simon Saubern ◽  
Christian H. Hornung
Keyword(s):  
Continuous Flow ◽  
Chemical Manufacture

scholarly journals Evaluating the Green Credentials of Flow Chemistry towards Industrial Applications

Synthesis ◽  
2021 ◽  
Author(s):  
Marcus Baumann ◽  
Thomas S Moody ◽  
Megan Smyth ◽  
Scott Wharry
Keyword(s):  
Continuous Flow ◽  
Flow Chemistry ◽  
Short Review ◽  
Batch Processing ◽  
Industrial Applications ◽  
Technology Platform ◽  
Frequent Application ◽  
Industrial Chemical ◽  
Continuous Flow Chemistry ◽  
Chemical Manufacture

Continuous flow chemistry is becoming an established technology platform that finds frequent application in industrial chemical manufacture with support and endorsements by the FDA for pharmaceuticals. Amongst the various advantages that are commonly cited for flow chemistry over batch processing, sustainability continues to require further advances and joint efforts by chemists and chemical engineers in both academia and industry. This short review highlights developments within the last 5 years that positively impact on the green credentials associated with flow chemistry, specifically when applied to the preparation of pharmaceuticals. An industrial perspective on current challenges is provided to whet discussion and stimulate further investment towards achieving greener modern synthetic technologies.

Catalyst- and oxidant-free electrochemical para-selective hydroxylation of N-arylamides in batch and continuous-flow

2020 ◽  
Vol 22 (19) ◽  
pp. 6437-6443
Author(s):  
Cheng-Kou Liu ◽  
Meng-Yi Chen ◽  
Xin-Xin Lin ◽  
Zheng Fang ◽  
Kai Guo
Keyword(s):  
Ammonium Salt ◽  
Quaternary Ammonium ◽  
Continuous Flow ◽  
Quaternary Ammonium Salt ◽  
Selective Hydroxylation

A catalyst-, oxidant-, acidic solvent- and quaternary ammonium salt-free electrochemical para-selective hydroxylation of N-arylamides at rt in batch and continuous-flow was developed.

Development of a Progression-Based Signal-Timing Strategy for Continuous-Flow Intersections

2021 ◽  
Vol 147 (3) ◽  
pp. 04021002
Author(s):  
Wenrui Qu ◽  
Shaojie Liu ◽  
Qun Zhao ◽  
Yi Qi
Keyword(s):  
Continuous Flow ◽  
Signal Timing

Avalanche Stratification - Experimental Tests of the “Metastable Wedge” and “Continuous Flow” Models

2000 ◽  
Vol 627 ◽  
Author(s):  
M. E. Swanson ◽  
M. Landreman ◽  
J. Michel ◽  
J. Kakalios
Keyword(s):  
Continuous Flow ◽  
Granular Media ◽  
Experimental Tests ◽  
Coarse Sand ◽  
Angle Of Repose ◽  
Flow Models ◽  
Maximum Angle ◽  
Stratification Effect ◽  
Upward Moving ◽  
Moving Layer

ABSTRACTWhen an initially homogeneous binary mixture of granular media such as fine and coarse sand is poured near the closed edge of a “quasi-two-dimensional” Hele-Shaw cell consisting of two vertical transparent plates held a narrow distance apart, the mixture spontaneously forms alternating segregated layers. Experimental measurements of this stratification effect are reported in order to determine which model, one which suggests that segregation only occurs when the granular material contained within a metastable heap between the critical and maximum angle of repose avalanches down the free surface, or one for which the segregation results from smaller particles becoming trapped in the top surface and being removed from the moving layer during continuous flow. The result reported here indicate that the Metastable Wedge model provides a natural explanation for the initial mixed zone which precedes the formation of the layers, while the Continuous Flow model explains the observed upward moving kink of segregated material for higher granular flux rates, and that both mechansims are necessary in order to understand the observed pairing of segregated layersfor intermediate flow rates and cell separations.

Room Temperature Flow Electrochemistry as a Means of Retaining the “Memory of Chirality” via Hofer Moest Type Reaction

2020 ◽  
Author(s):  
Tomas Hardwick ◽  
Rossana Cicala ◽  
Nisar Ahmed
Keyword(s):  
Continuous Flow ◽  
Room Temperature ◽  
Biological Activities ◽  
Supporting Electrolyte ◽  
Enantiomeric Excess ◽  
Flow Chemistry ◽  
Batch Processes ◽  
Enabling Technology ◽  
Chiral Compounds ◽  
Memory Of Chirality

<p>Many chiral compounds have become of great interest to the pharmaceutical industry as they possess various biological activities. Concurrently, the concept of “memory of chirality” has been proven as a powerful tool in asymmetric synthesis, while flow chemistry has begun its rise as a new enabling technology to add to the ever increasing arsenal of techniques available to the modern day chemist. Here, we have employed a new simple electrochemical microreactor design to oxidise an L-proline derivative at room temperature in continuous flow. Flow performed in microreactors offers up a number of benefits allowing reactions to be performed in a more convenient and safer manner, and even allow electrochemical reactions to take place without a supporting electrolyte due to a very short interelectrode distance. By the comparison of electrochemical oxidations in batch and flow we have found that continuous flow is able to outperform its batch counterpart, producing a good yield (71%) and a better enantiomeric excess (64%) than batch with a 98% conversion. We have, therefore, provided evidence that continuous flow chemistry has the potential to act as a new enabling technology to replace some aspects of conventional batch processes. </p>

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