Engineering the Design of Brightly-Emitting Luminescent Nanostructured Photonic Composite Systems

2013 ◽  
Vol 66 (9) ◽  
pp. 1008 ◽  
Author(s):  
Mei Chee Tan ◽  
Dominik J. Naczynski ◽  
Prabhas V. Moghe ◽  
Richard E. Riman
Keyword(s):  
Rare Earth ◽  
Optical Waveguides ◽  
Impact Resistance ◽  
Synthesis Method ◽  
Research Progress ◽  
Design And Synthesis ◽  
Composite Systems ◽  
Rare Earth Doped

Rare-earth doped infrared emitting composites have extensive applications in integrated optical devices such as fibre amplifiers and waveguides for telecommunications, remote sensing, and optoelectronics. In addition, recent advancements in infrared optical imaging systems have expanded the biomedical applications for infrared-emitting composites in diagnosis and imaging of living tissue systems both in vitro and in vivo. Composite systems combine the advantages of polymers (light weight, flexibility, good impact resistance, improved biomedical compatibility, and excellent processability) and inorganic phosphor host materials (low phonon energy, intense emissions, chemical durability, and high thermal stability). This paper provides a brief review of our research progress in the design and synthesis of luminescent photonic nanocomposite systems comprised of rare-earth doped particulates dispersed in a continuous polymeric matrix. The design of brightly-emitting rare-earth doped materials and the influence of host and dopant chemistries on the emission properties are discussed. Methods used to assess and measure the phosphors’ performance are also evaluated in this work. This paper will also examine the solvothermal synthesis method used to control the physical and chemical characteristics of the rare-earth doped particles, and how these characteristics impact the infrared optical properties. Also presented here are recent advances reported with luminescent nanocomposite systems fabricated for optical waveguides and biomedical imaging.

scholarly journals A small molecule HIF-1α stabilizer that accelerates diabetic wound healing

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Guodong Li ◽  
Chung-Nga Ko ◽  
Dan Li ◽  
Chao Yang ◽  
Wanhe Wang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Small Molecule ◽  
Hypoxia Inducible Factor ◽  
Diabetic Patients ◽  
Diabetic Mice ◽  
Impaired Wound Healing ◽  
Von Hippel Lindau ◽  
Design And Synthesis

AbstractImpaired wound healing and ulcer complications are a leading cause of death in diabetic patients. In this study, we report the design and synthesis of a cyclometalated iridium(III) metal complex 1a as a stabilizer of hypoxia-inducible factor-1α (HIF-1α). In vitro biophysical and cellular analyses demonstrate that this compound binds to Von Hippel-Lindau (VHL) and inhibits the VHL–HIF-1α interaction. Furthermore, the compound accumulates HIF-1α levels in cellulo and activates HIF-1α mediated gene expression, including VEGF, GLUT1, and EPO. In in vivo mouse models, the compound significantly accelerates wound closure in both normal and diabetic mice, with a greater effect being observed in the diabetic group. We also demonstrate that HIF-1α driven genes related to wound healing (i.e. HSP-90, VEGFR-1, SDF-1, SCF, and Tie-2) are increased in the wound tissue of 1a-treated diabetic mice (including, db/db, HFD/STZ and STZ models). Our study demonstrates a small molecule stabilizer of HIF-1α as a promising therapeutic agent for wound healing, and, more importantly, validates the feasibility of treating diabetic wounds by blocking the VHL and HIF-1α interaction.

scholarly journals Structure Based Design and Synthesis of Peptide Inhibitor of Human LOX-12: In Vitro and In Vivo Analysis of a Novel Therapeutic Agent for Breast Cancer

PLoS ONE ◽  
2012 ◽  
Vol 7 (2) ◽  
pp. e32521 ◽  
Author(s):  
Abhay kumar Singh ◽  
Ratnakar Singh ◽  
Farhat Naz ◽  
Shyam Singh Chauhan ◽  
Amit Dinda ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Therapeutic Agent ◽  
Peptide Inhibitor ◽  
Design And Synthesis ◽  
In Vivo Analysis ◽  
Novel Therapeutic

scholarly journals Ultrasound-Mediated Local Drug and Gene Delivery Using Nanocarriers

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Qiu-Lan Zhou ◽  
Zhi-Yi Chen ◽  
Yi-Xiang Wang ◽  
Feng Yang ◽  
Yan Lin ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Research Progress ◽  
Great Promise ◽  
Blood Capillary ◽  
Tumor Tissues ◽  
Ultrasound Molecular Imaging ◽  
Pass Through ◽  
Capillary Walls

With the development of nanotechnology, nanocarriers have been increasingly used for curative drug/gene delivery. Various nanocarriers are being introduced and assessed, such as polymer nanoparticles, liposomes, and micelles. As a novel theranostic system, nanocarriers hold great promise for ultrasound molecular imaging, targeted drug/gene delivery, and therapy. Nanocarriers, with the properties of smaller particle size, and long circulation time, would be advantageous in diagnostic and therapeutic applications. Nanocarriers can pass through blood capillary walls and cell membrane walls to deliver drugs. The mechanisms of interaction between ultrasound and nanocarriers are not clearly understood, which may be related to cavitation, mechanical effects, thermal effects, and so forth. These effects may induce transient membrane permeabilization (sonoporation) on a single cell level, cell death, and disruption of tissue structure, ensuring noninvasive, targeted, and efficient drug/gene delivery and therapy. The system has been used in various tissues and organs (in vitro or in vivo), including tumor tissues, kidney, cardiac, skeletal muscle, and vascular smooth muscle. In this review, we explore the research progress and application of ultrasound-mediated local drug/gene delivery with nanocarriers.

scholarly journals The Antiviral Effect of Novel Steroidal Derivatives on Flaviviruses

2021 ◽  
Vol 12 ◽  
Author(s):  
Luping Zhang ◽  
Dengyuan Zhou ◽  
Qiuyan Li ◽  
Shuo Zhu ◽  
Muhammad Imran ◽  
...  
Keyword(s):  
Antiviral Effect ◽  
Therapeutic Drug ◽  
Dependent Manner ◽  
Design And Synthesis ◽  
Invasion Stage ◽  
Synthetic Derivatives ◽  
Dose Dependent ◽  
The Brain

Flaviviruses are the major emerging arthropod-borne pathogens globally. However, there is still no practical anti-flavivirus approach. Therefore, existing and emerging flaviviruses desperately need active broad-spectrum drugs. In the present study, the antiviral effect of steroidal dehydroepiandrosterone (DHEA) and 23 synthetic derivatives against flaviviruses such as Japanese encephalitis virus (JEV), Zika virus (ZIKV), and Dengue virus (DENV) were appraised by examining the characteristics of virus infection both in vitro and in vivo. Our results revealed that AV1003, AV1004 and AV1017 were the most potent inhibitors of flavivirus propagation in cells. They mainly suppress the viral infection in the post-invasion stage in a dose-dependent manner. Furthermore, orally administered compound AV1004 protected mice from lethal JEV infection by increasing the survival rate and reducing the viral load in the brain of infected mice. These results indicate that the compound AV1004 might be a potential therapeutic drug against JEV infection. These DHEA derivatives may provide lead scaffolds for further design and synthesis of potential anti-flavivirus potential drugs.

FimH Antagonists for the Oral Treatment of Urinary Tract Infections: From Design and Synthesis to in Vitro and in Vivo Evaluation

2010 ◽  
Vol 53 (24) ◽  
pp. 8627-8641 ◽  
Author(s):  
Tobias Klein ◽  
Daniela Abgottspon ◽  
Matthias Wittwer ◽  
Said Rabbani ◽  
Janno Herold ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Oral Treatment ◽  
In Vivo Evaluation ◽  
Design And Synthesis ◽  
Tract Infections

In vitro and in vivo investigations on the antiviral activity of a series of mixed-valence rare earth borotungstate heteropoly blues

2008 ◽  
Vol 43 (9) ◽  
pp. 1963-1970 ◽  
Author(s):  
Ya-Nan Liu ◽  
Shuo Shi ◽  
Wen-Jie Mei ◽  
Cai-Ping Tan ◽  
Lan-Mei Chen ◽  
...  
Keyword(s):  
Rare Earth ◽  
Antiviral Activity ◽  
Mixed Valence ◽  
Heteropoly Blues

scholarly journals Current Perspectives and Potential of Probiotics to Limit Foodborne Campylobacter in Poultry

2020 ◽  
Vol 11 ◽  
Author(s):  
Wenjun Deng ◽  
Dana K. Dittoe ◽  
Hilary O. Pavilidis ◽  
William E. Chaney ◽  
Yichao Yang ◽  
...  
Keyword(s):  
Foodborne Pathogen ◽  
Research Progress ◽  
Feed Additive ◽  
Future Research ◽  
Host Animal ◽  
Health And Nutrition ◽  
Efficient Control ◽  
Pathogen Colonization

Poultry has been one of the major contributors of Campylobacter related human foodborne illness. Numerous interventions have been applied to limit Campylobacter colonization in poultry at the farm level, but other strategies are under investigation to achieve more efficient control. Probiotics are viable microbial cultures that can establish in the gastrointestinal tract (GIT) of the host animal and elicit health and nutrition benefits. In addition, the early establishment of probiotics in the GIT can serve as a barrier to foodborne pathogen colonization. Thus, probiotics are a potential feed additive for reducing and eliminating the colonization of Campylobacter in the GIT of poultry. Screening probiotic candidates is laborious and time-consuming, requiring several tests and validations both in vitro and in vivo. The selected probiotic candidate should possess the desired physiological characteristics and anti-Campylobacter effects. Probiotics that limit Campylobacter colonization in the GIT rely on different mechanistic strategies such as competitive exclusion, antagonism, and immunomodulation. Although numerous research efforts have been made, the application of Campylobacter limiting probiotics used in poultry remains somewhat elusive. This review summarizes current research progress on identifying and developing probiotics against Campylobacter and presenting possible directions for future research efforts.

Emerging Role of Chinese Herbal Medicines in the Treatment of Pancreatic Fibrosis

2019 ◽  
Vol 47 (04) ◽  
pp. 709-726 ◽  
Author(s):  
Chang Liu ◽  
Shuang Li ◽  
Qingkai Zhang ◽  
Fangyue Guo ◽  
Mengying Tong ◽  
...  
Keyword(s):  
Herbal Medicines ◽  
Pancreatic Fibrosis ◽  
Research Progress ◽  
Common Disease ◽  
Innovative Drug ◽  
Chinese Herbal ◽  
Pathologic Characteristic ◽  
Prevention And Cure

Pancreatic fibrosis is the main pathologic characteristic in chronic pancreatitis (CP), a common disease that arises from surgery. Pancreatitis is caused by various etiologies, but the mechanism of fibrosis is not completely understood. Existing clinical approaches mainly focus on mitigating the symptoms and therefore do not cure the phenomena. In recent years, there has been a heightened interest in the use of Chinese herbal medicine (CHMs) in the prevention and cure of CP as expressed by increasing numbers of clinical and experimental research. Despite early cell culture and animal models, CHMs are able to interact with plenty of molecular targets involved in the pathogenesis of pancreatic fibrosis mostly via the TGF-[Formula: see text]/Smads pathway; however, integrated and up-to-date communication in this domain is unavailable. This review focuses on the research progress of CHMs against pancreatic fibrosis due to CP in vitro and in vivo and summarizes the potential mechanisms. We also outlined the toxicology of some CHMs for fibrosis treatment in order to provide a fuller understanding of drug safety. This review may provide reference for further innovative drug research and the future development of treatments for CP with pancreatic fibrosis.

Rare-earth doped materials for optical waveguides

2015 ◽  
Author(s):  
Dominik Dorosz ◽  
Marcin Kochanowicz ◽  
Jacek Zmojda ◽  
Piotr Miluski ◽  
M. Marciniak ◽  
...  
Keyword(s):  
Rare Earth ◽  
Optical Waveguides ◽  
Doped Materials ◽  
Rare Earth Doped
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