Invited Review. Combinatorial Synthesis: A Heterocyclic Chemist's Perspective

1998 ◽  
Vol 51 (10) ◽  
pp. 875 ◽  
Author(s):  
Wendy A. Loughlin
Keyword(s):  
Heterocyclic Compounds ◽  
Combinatorial Synthesis ◽  
Solution Phase ◽  
Recent Developments

An overview of the combinatorial synthesis of heterocyclic compounds is presented. Recent developments and innovations in the solid and solution phase combinatorial synthesis of heterocyclic compounds are discussed.

scholarly journals Recent advances in the electrochemical construction of heterocycles

2014 ◽  
Vol 10 ◽  
pp. 2858-2873 ◽  
Author(s):  
Robert Francke
Keyword(s):  
Heterocyclic Compounds ◽  
Elevated Temperatures ◽  
Ring Formation ◽  
Environmentally Benign ◽  
Heterocyclic Chemistry ◽  
Ambient Conditions ◽  
Recent Developments ◽  
Strong Acids ◽  
Selection Of ◽  
Made In

Due to the fact that the major portion of pharmaceuticals and agrochemicals contains heterocyclic units and since the overall number of commercially used heterocyclic compounds is steadily growing, heterocyclic chemistry remains in the focus of the synthetic community. Enormous efforts have been made in the last decades in order to render the production of such compounds more selective and efficient. However, most of the conventional methods for the construction of heterocyclic cores still involve the use of strong acids or bases, the operation at elevated temperatures and/or the use of expensive catalysts and reagents. In this regard, electrosynthesis can provide a milder and more environmentally benign alternative. In fact, numerous examples for the electrochemical construction of heterocycles have been reported in recent years. These cases demonstrate that ring formation can be achieved efficiently under ambient conditions without the use of additional reagents. In order to account for the recent developments in this field, a selection of representative reactions is presented and discussed in this review.

Solution phase combinatorial synthesis of arylpiperazines

1997 ◽  
Vol 38 (23) ◽  
pp. 4091-4094 ◽  
Author(s):  
Luc Neuville ◽  
Jieping Zhu
Keyword(s):  
Combinatorial Synthesis ◽  
Solution Phase

Combinatorial synthesis of trisaccharides via solution-phase one-pot glycosylation

2000 ◽  
Vol 41 (15) ◽  
pp. 2599-2603 ◽  
Author(s):  
Takashi Takahashi ◽  
Masaatsu Adachi ◽  
Akihisa Matsuda ◽  
Takayuki Doi
Keyword(s):  
Combinatorial Synthesis ◽  
Solution Phase ◽  
One Pot
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