scholarly journals Effect of Intravenously Infused Dexamethasone on Collagen Metabolism in Skin of Merino Sheep

1979 ◽  
Vol 32 (6) ◽  
pp. 561
Author(s):  
Z Leish ◽  
BA Panaretto

The effects of an 8-day intravenous infusion of dexamethasone (7�6 mg kg-o.75 body weight) on collagen biosynthes's and wool growth in skin were examined in four Merino wethers.

1967 ◽  
Vol 20 (1) ◽  
pp. 153 ◽  
Author(s):  
PJ Reis ◽  
DA Tunks ◽  
OB Williams ◽  
AJ Williams

The sulphur content of wool from 66 Peppin Merino wethers maintained together at pasture was measured in midside staples representing 49 weeks growth. The distribution of sulphur values was normal with a mean of 3�43 % and a range of 3�08-3�92 %. The sulphur content of the wool was inversely related to wool production among these sheep. There were no significant differences in the relationship when wool production was expressed as fleece weight index (F.W.I.), i.e. clean fleece weight/body weight (r = -0�48), as clean fleece weight (r = -0�42), or as wool growth per unit area of skin (r = - 0�37). The mean sulphur content of wool from sheep with the 10 highest values for F.W.I. was 3�27%, compared with a mean of 3 �55% sulphur for wool from sheep with the 10 lowest values for F.W.I.


1980 ◽  
Vol 31 (4) ◽  
pp. 791
Author(s):  
DA Tunks ◽  
RDG Rigby ◽  
AM Downes ◽  
JA Lamberton ◽  
BA Panaretto ◽  
...  

Merino sheep, offered feed at two levels of intake, were given an oral dose of N-[5-(4-am1nophenoxy)- pentyllphthahmide at rates varying over 100-800 mg/kg body weight. Consistent defleecing was obtained at dose rates of 400 nig/kg and above. Feed intake did not Influence defleecing activity. lntravenous infusion of smaller amounts also allowed defleecing. Wool growth rate following dosing was not affected by a dose of 100 mg/kg, but doses of 200 and 400 mg/kg caused depressions of c. 15 and c. 70% respectively in the rate of wool growth in the 2 weeks after dosing. Blindness was observed In one sheep dosed at 400 mg/kg and In all sheep dosed at higher rates


1975 ◽  
Vol 28 (6) ◽  
pp. 483 ◽  
Author(s):  
PJ Reis

Merino sheep were given continuous intravenous infusions of L-mimosine for periods of It, 2 or 21 days; efficacy as a defleecing procedure and effects on subsequent wool growth were measured. In addition, the amino acids tyrosine, phenylalanine and cystine were investigated as antagonists to the effects of mimosine.


1975 ◽  
Vol 28 (1) ◽  
pp. 69 ◽  
Author(s):  
PJ Reis ◽  
DA Tunks ◽  
RE Chapman

Twenty-two Merino sheep were dosed with various amounts of L-mimosine, given either as an intravenous or an intraperitoneal injection, or as a continuous intravenous infusion for periods of 1-4 days.


1961 ◽  
Vol 1 (2) ◽  
pp. 85 ◽  
Author(s):  
AM Stewart ◽  
RJ Moir ◽  
PG Schinckel

The growth rate of wool was measured at monthly intervals for a period of two years in four groups totalling forty Merino sheep, maintained under typical farm conditions in a Mediterranean climatic environment. Marked seasonal fluctuation in wool growth was found in all sheep. The highest level of clean wool production, 85 attained in the spring months, was nearly three times that of the lowest level, which occurred in the autumn. The rate of wool growth fluctuated independently of body weight. Wool growth fell steep4 while bob weight was maintained; wool growth subsequently rose sharply while body weight increased relatively slowly. The factors responsible for the observed fluctuation in the rate of wool growth are discussed and the conclusion reached that lack of useful energy and protein, in the summer and autumn grazing is probably the principal cause of the decline in rate of wool growth in these months.


1974 ◽  
Vol 25 (6) ◽  
pp. 931 ◽  
Author(s):  
PJ Reis ◽  
RE Chapman

Two Merino sheep were dosed orally, and two intravenously, with cyclophosphamide at the rate of 30 mg/kg body weight; the effects on wool growth were measured, and changes in the histology of skin and of wool follicles were studied. All sheep were readily defleeced following treatment. This effect was associated with a complete cessation of wool growth for a period of about 2 weeks with oral dosing and 2½ weeks with intravenous dosing. There was considerable variation in the time taken for new fibres to commence growth. Length growth rates during the period 28–36 days after dosing were consistently greater than pre-treatment rates. Post-treatment fibre diameters were variable compared with the pretreatment values. The extent to which the enhanced length growth after dosing would compensate for the loss of wool growth requires further investigation. Degenerative changes were observed in some wool follicles 1 hr after dosing, and proliferation of cells of the fibre and inner root sheath appeared to have ceased at 1 day. Fibre growth ceased prior to 4 days. Regeneration of most follicles commenced prior to 14 days after dosing, and regrowth of wool was apparent above the skin by 21 days. A small proportion of follicles was still inactive after 36 days. Changes were observed in the sebaceous and sweat glands, epidermis and dermis following dosing. Even 36 days after dosing, sebaceous glands were considerably enlarged and excess stratum corneum remained on the epidermis. Infiltration of the dermis by lymphocytes was observed as early as 1 hr after dosing and was intense by 28 days.


1986 ◽  
Vol 39 (3) ◽  
pp. 209 ◽  
Author(s):  
PJ Reis ◽  
DA Tunks ◽  
RDG Rigby ◽  
SG Munro ◽  
RW Edols

Methoxinine (O-methyl-DL-homoserine) was given to 18 Merino sheep by intravenous infusion or injection in amounts of 52-100 mg/kg body weight. Effects on strength, morphology and growth rate of wool fibres were studied.


1963 ◽  
Vol 3 (11) ◽  
pp. 269 ◽  
Author(s):  
W Ahmed ◽  
RB Dun ◽  
RJ Winston

The efficiency of conversion of feed to wool was measured in three jocks of Peppin Merino sheep, namely : Fleece Plus-Selected for nine years on high clean fleece weight ; Fleece Minus-Selected for nine years on low clean fleece weight ; Random-An unselected, control flock. Ten 18 month old ewes from each of these flocks were individually housed and fed ad lib on hammer-milled lucerne hay for 54 weeks. Highly significant differences between flocks were observed in feed intake, wool growth, and efficiency of conversion of feed to wool. The relative productive levels for the Fleece Plus, Random and Fleece Minus flocks were-for feed intake, 108 : 100 : 88-for clean fleece weight, 118 : 100 : 70-and for efficiency 109 : 100 : 79. The correlation between efficiency and daily feed intake was very highly significant and negative within each flock, (-0.918, -0.929 and -0.924, for Fleece Plus, Random and Fleece Minus flocks respectively), whereas the correlation between jocks was significantly positive, r = 0.997. The relative importance of the factors determining the 18 per cent increase in clean fleece weight of the Fleece Plus over the Random flock was : efficiency, 55 per cent and feed intake, 45 per cent-and comparing the Random to the Fleece Minus flock : efficiency, 60 per cent and feed intake, 40 per cent. Approximately half the difference in feed intake was independent of body weight.


1989 ◽  
Vol 40 (2) ◽  
pp. 433 ◽  
Author(s):  
SI Mortimer ◽  
KD Atkins

Wool production traits were measured on Merino hogget ewes in an unselected multiple-bloodline flock over a 7-year period at Trangie Agricultural Research Centre, N.S.W. The traits measured were greasy fleece weight (GFW), skirted fleece weight (SKFW), yield (Y), clean fleece weight (CFW), fibre diameter (FD), body weight (BWT) and staple length (SL). These measurements were used to examine genetic differences between and within flocks of Merino sheep, and to estimate heritability of and genetic and phenotypic correlations among these traits. Significant strain, flock within strain and flock effects were present for all traits. Interactions between these effects and year were non-significant. Within-flock genetic variance was always larger than between-flock within strain genetic variance for each trait. The influence of environmental effects on these traits was also examined. The environmental effects of birth-rearing type, age at observation and age of dam together accounted for about 7-10% of the total within-flock variation in fleece weights and body weight.After adjusting for significant environmental effects, paternal half-sib heritability estimates were 0.29 �. 0.06 for GFW, 0.22 � 0.05 for SKFW, 0.35 � 0.05 for Y, 0.30 �0.06 for CFW, 0.48 �0.07 for FD, 0.34 �. 0.06 for BWT and 0.44 �0.07 for SL. Estimates for genetic and phenotypic correlations were in agreement with published estimates except for the genetic correlation between CFW and FD (0.40 �. 0.11), and the genetic correlations involving BWT, which were essentially zero. The implications of the results of this study for the genetic improvement of Merino sheep for wool production are discussed.


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