Effects of Trichostrongylus colobriformis (Nematoda) on the nutrition and metabolism of sheep. IV.* Glucose metabolism

1977 ◽  
Vol 28 (4) ◽  
pp. 713
Author(s):  
FB Roseby

The effect of infection with Trichostrongylus co!ubriformis on quantitative aspects of glucose metabolism was studied in 12 Merino lambs. Total entry rate, rate of irreversible loss and rate of recycling were measured simultaneously by means of [U-14C]glucose and [3-3H]glucose. The feed intake of all sheep was maintained at 540 g/day throughout the experiment. The total entry rate of glucose in infected sheep was greater than in their controls. There was a smaller difference in the irreversible loss of glucose because of increased recycling of glucose carbon in infected sheep. It was concluded that the rate of glucose synthesis was higher in infected sheep compared with control sheep on the same feed intake, because there was more recycling and possibly increased availability of propionate from the large intestine. However, this increase would not compensate for the reduced intake of glucose precursors by infected sheep fed ad libitum, so the overall effect of T. colubriformis infection would be to reduce glucose synthesis. ___________________ *Part III, Aust. J. Agric. Res., 28: 155 (1977).

1976 ◽  
Vol 54 (5) ◽  
pp. 737-751 ◽  
Author(s):  
E. H. McEwan ◽  
Pamela Whitehead ◽  
R. G. White ◽  
J. O. Anvik

Glucose parameters were estimated by multicompartmental analysis after the single injection of [U-14C] glucose in pen-fed reindeer and caribou. During the rut, the plasma concentration, pool size, space, total entry rate, irreversible loss, and glucose turnover time of male reindeer and caribou declined; all parameters increased significantly after the rut ended and feeding had begun again. In female reindeer and caribou the lowest estimates of glucose pool, space, total entry rate, and irreversible loss were noted during midpregnancy (February–April). During early lactation (May–June) significant increases were noted in total entry rate, irreversible loss, and the plasma concentration of glucose.For non-lactating reindeer and caribou, inflections in relationships between glucose total entry rate and irreversible loss with digestible energy intake were noted at a daily digestible intake of about 195 kcal/W0.75 (where W0.75 = metabolic body weight); three times more glucose was synthesized per unit digestible energy intake above the point of inflection than was synthesized below it. Per unit of protein intake, total entry rate and irreversible loss of glucose for males exceeded that of the females by 4 to 5 mg/W0.75 per minute. In female reindeer and caribou a close correlation was noted between the glucose irreversible loss and total entry rate. Glucose resynthesis was constant at 1.5 mg/W0.75 per minute.


1979 ◽  
Vol 92 (2) ◽  
pp. 323-327 ◽  
Author(s):  
E. J. H. Ford ◽  
A. R. Samad ◽  
Hilary Pursell

SummaryNormal and ketotio ewes pregnant with twin lambs were injected intramuscularly with 0·5 mg/kg body weight of trienbolone acetate. In the normal animals there was no significant change in the concentration of glucose, ketones, glycerol or NEFA in plasma.Induction of ketosis by starvation produced a significant fall in the concentration of glucose in plasma and significant increases in the concentration of ketones, glycerol and NEFA. Trienbolone caused no further significant changes in the concentration of the four metabolites in the plasma of ketotio sheep.Primed continuous simultaneous intravenous infusions of tracer amounts of [2-3H] and [U-14C]glucose were used to measure total entry rate and irreversible loss of glucose. Trienbolone caused significant decreases in both these measurements in normal pregnant sheep. Production of ketosis by starvation had the same effect. Trienbolone produced no significant additional effect in the ketotic sheep and no alleviation of the clinical signs of the hyperglycaemic ketosis.These results are discussed in relation to the assessment of the potential value of trienbolone as a treatment of pregnancy toxaemia of sheep.


1980 ◽  
Vol 95 (2) ◽  
pp. 241-250 ◽  
Author(s):  
D. M. Murray ◽  
Olga Slezacek

SUMMARYThe effect of three different growth rates from 15 to 40 kg live weight on some offal components of lambs was studied. The treatments were: high (H) ad-libitum feed intake, low (L) restricted feed intake and high-maintenance-high (HMH) ad-libitum feed intake from 15 to 25 kg followed by a 50-day period of weight stasis, which was followed by ad-libitum feeding. In each treatment, two animals were killed at 25, 30 and 35 kg and three animals at 40 kg. Analyses of covariance were used to compare linear regression equations representing results from each treatment using the logarithmic transformation of the allometric equation, y = axb.Differences between treatments were found for the weight of certain non-alimentary tract offals including the liver (H, HMH > L), kidney (H, HMH > L), skin (H, HMH > L) and hind-hooves (H < HMH, L). The slope of the regression for the heart, liver, kidney, and the combined trachea and lungs was greater in the HMH, than in the H, treatment. These differences in slope were attributed to a decrease in weight of each component in the HMH animals during weight stasis except for the lungs and trachea, where the greater slope was due to an increased weight of this component in the HMH animals killed at 40 kg.Fat-trimmed weights of the omasum, abomasum, small intestine and large intestine were greater in both the H and HMH animals than the L animals. The weights both of the rumen-reticulum and total alimentary tract (TAT) were less at 25 kg in HMH animals than in either H or L animals although, overall, the weight of TAT was greater in the H and HMH treatments than in the L treatment. A comparison of data for the H and HMH treatments showed that weight stasis decreased the weight of all separate parts of the alimentary tract, particularly the rumen-reticulum and the small intestine.Chemical analyses (water, N × 6·25 and ether extract) were conducted on four alimentary tract components, namely the combined rumen-reticulum and omasum (RRO) abomasum, small intestine and large intestine. The results of these analyses showed that composition was similar in the three treatments despite treatment effects on the weight of some parts of the tract.Chemical data were pooled across treatments to compare composition of the different alimentary tract components. This analysis showed that chemical composition was different both for all parts of the tract and for all chemical components with two exceptions. There was no difference between the RRO and small intestine for either water or ether extract.Common regression equations are presented for each component of the alimentary tract relating the weights of three chemical components to tissue weight. Water and protein content were more closely related to tissue weight than was ether extract. It is suggested that both water and protein content may show a sufficiently close relationship to tissue weight whereby they may be predicted from a knowledge of the latter, particularly the RRO and small intestine.There were no differences between treatments in the weights of fat trimmed from the alimentary tract despite treatment effects on either the weight of some parts of the tract or other offals.Apart from a greater weight of digesta in the small intestine in the H animals than in L animals relatively minor differences between treatments were found in the amounts of digesta in different parts of the tract.


2020 ◽  
Vol 98 (Supplement_4) ◽  
pp. 393-394
Author(s):  
Camila D A Batalha ◽  
Fabiana L De Araújo ◽  
Renata H Branco ◽  
Luis O Tedeschi ◽  
Sarah F Bonilha

Abstract Retained energy (RE) and energetic efficiency index were measured in Nellore bulls from divergent classes of residual feed intake (RFI). Thirty-four Nellore bulls (15 low RFI-LRFI and 19 high RFI-HRFI) were feedlot finished and slaughtered with 385 ± 40 kg of body weight (BW) and 520 ± 26.2 days of age. At the beginning of the experiment, five LRFI and three HRFI were slaughtered and used as base line. Individual dry matter intake was recorded daily; initial and final BW were recorded after 16 h of fasting. Eight bulls, four LRFI and four HRFI, were fed at maintenance, receiving 65 g of DM/kg0.75 BW, and 18 bulls (10 LRFI and eight HRFI) were fed ad libitum. Diet had 19:81 roughage:concentrate, 88% of DM and 15% of crude protein. Ultrasound measurements on the Longissimus muscle were performed at intervals of 28 days. When two ad libitum bulls reached 4 mm of subcutaneous fat thickness, one maintenance bull was randomly chosen and slaughtered on the same day. After slaughter, the centesimal composition of the empty body and carcass was measured. Data were analyzed using a random coefficients model, and RFI class was included as a fixed effect. Least-square means were used to compare the means, and significance was declared for P ≤ 0.05. The LRFI had greater protein retention than HRFI (248 vs. 142 g/d; P = 0.009), and same fat and energy retention (313 g/d and 4.12 Mcal/d, respectively). The energy efficiency indexes, heat production per metabolic energy intake (Mcal/Mcal) and gain-to-feed (kg/kg) ratio, did not differ between RFI classes. Though LRFI had the same energy efficiency index, they were leaner. These results indicated an association of RFI and maturity patterns. Further research is needed to estimate the net energy requirements of Nellore bulls classified according to RFI. Acknowledgments: FAPESP Processes 2017/06709-2, 2018/20080–2 and 2019/17714-2.


2014 ◽  
Vol 54 (3) ◽  
pp. 319 ◽  
Author(s):  
Ronald E. Newman ◽  
Jeffery A. Downing ◽  
Peter C. Thomson ◽  
Cherie L. Collins ◽  
David J. Henman ◽  
...  

Three studies investigated the effect of feeding strategy on production performance and endocrine status of growing pigs. For Experiment 1, 20 entire male pigs (70.0 ± 4.6 kg) were allocated randomly to individual pens in one of four climate-controlled rooms. Pigs were fed for 23 days either ad libitum or entrained to feed bi-phasically for two 90-min periods. For Experiment 2, 20 entire male pigs (41.2 ± 3.5 kg) were housed as per Experiment 1. Pigs were fed for 49 days either ad libitum or fed bi-phasically for two 60-min periods. For Experiment 3, 100 female pigs (66.1 ± 3.5 kg) were randomly allocated to individual pens within a commercial piggery and fed for 42 days either ad libitum or bi-phasically for two 60-min periods. Ear vein catheters were inserted into 10 pigs from each group and hourly blood samples were collected for 24 h in Experiments 1 and 2 and for 11 h in Experiment 3. Plasma insulin, non-esterified fatty acid and glucose concentrations were determined in Experiments 1 and 2, and glucose and insulin concentrations in Experiment 3. Feed intake and performance were recorded in all experiments and carcass composition was assessed by computed tomography for Experiment 2. There were no differences in final liveweight between the two treatment groups for all experiments. Pigs fed for two 90-min periods (Experiment 1) showed no difference in feed intake when compared with feeding ad libitum. Pigs in Experiment 2 fed for two 60-min intervals consumed 2.49 kg/pig.day compared with those fed ad libitum that consumed 2.68 kg/day (P = 0.057). In Experiment 3, pigs fed twice daily consumed 2.82 kg/pig.day compared with 2.91 kg/pig.day in ad libitum-fed pigs (P = 0.051). Bi-phasic fed pigs in Experiment 2 had improved (P < 0.05) feed conversion efficiency compared with pigs fed ad libitum. For all experiments, there was no difference in plasma glucose concentrations between the two treatments. In all three experiments, the circulating insulin concentrations for pigs fed ad libitum remained at a constant level throughout the sampling period. However, plasma insulin concentrations for the bi-phasic fed pigs significantly increased ~1 h after both feeding periods during all three experiments. Insulin secretion of pigs fed for two 90-min periods differed from that of pigs fed for two 60-min periods. Plasma insulin concentration increased five-fold following feeding for 60 min, compared with that in pigs fed for 90 min, which increased two-fold. Bi-phasic-fed pigs from Experiment 2 had reduced (P < 0.05) total carcass fat and significantly increased muscle when compared with pigs fed ad libitum. The data showed that feeding pigs at two succinct periods aligned insulin secretion to the time of feeding. Pigs fed for 60 min, unlike those fed for 90-min intervals, had reduced feed intake in comparison to those fed ad libitum. This may suggest that the duration of the feeding bout is important for this response and this may in turn influence both energy balance and the way energy is partitioned.


1986 ◽  
Vol 26 (6) ◽  
pp. 647
Author(s):  
RT Norris ◽  
CL McDonald ◽  
JB Rowe

The accuracy with which monensin could control feed intake was studied in 200 3-4-year-old Merino wethers by measuring their intake of pelleted diets containing 5 levels of monensin: 0, 33, 66, 132 or 264 mg/kg of feed. The feed was offered ad libitum for 25 days except for the highest level of monensin where treatment was ended after 12 days.Mean daily intakes (g/sheep) of diets containing monensin at 0, 33, 66, 132 or 264 mg/kg feed were 1304, 959, 793, 403 and 137 respectively. Mean daily feed intake (Y, g) was negatively and linearly related to concentration of monensin (X, mg/kg feed) Y = 1244 - 6.57X (r2=0.98; P<0.05) Similarly there was a close negative relationship between the concentration of monensin (X, mg/kg feed) and daily liveweight change (Z, g/sheep) during the trial Z = 217 - 2.61X (r2=0.99; P< 0.01) From this relationship, maintenance of liveweight would have been achieved with a diet containing monensin at about 80 mg/kg feed. Signs of toxicity including deaths occurred in sheep receiving diets containing monensin at 66, 132 and 264 mg/kg feed. It was concluded that monensin could be used to restrict feed intake but further research is necessary to determine safe levels.


1993 ◽  
Vol 73 (1) ◽  
pp. 159-167 ◽  
Author(s):  
F. E. Robinson ◽  
M. W. Yu ◽  
M. E. Lupicki ◽  
R. T. Hardin

The immediate effects of a sudden increase in feed allowance on selected morphological and reproductive traits were investigated in broiler breeder hens at 44 wk of age. Fifty Indian River hens were individually caged at 40 wk of age. Prior to 40 wk of age the birds had been feed restricted in accordance with the breeder's recommended feeding program. Five treatment groups (T1, T2, T3, T4 and T5) of 10 birds each were formed based on level of feeding and duration of exposure to such feeding. T1, T2 and T3 birds were feed restricted (128 g of daily feed bird−1) from 40 to 44, 40 to 45 and 40 to 46 wk of age, respectively. T4 and T5 birds were also feed restricted at the same level as the other groups to 44 wk of age and then were full fed from 44 to 45 and 44 to 46 wk of age, respectively. To facilitate study of follicular recruitment and yolk deposition, hens were fed 10 g of oil-soluble red and black dyes, daily, on alternate days, beginning at 42 wk of age. Birds were killed on day 0 (44 wk; T1), day 7 (45 wk; T2, T4), or day 14 (46 wk; T3, T5). Full-fed hens consumed approximately 100 g more feed per day than did feed-restricted hens, with marked increases in feed intake on the first day of full feeding. After 7 d of ad libitum feeding, significant increases were seen in body weight, liver weight, percent liver fat, plasma lipid concentration, ovary weight, and the incidence of a double hierarchy (simultaneous development) of large follicles. After 14 d of ad libitum feeding, significant increases were also observed in absolute fat-pad weight, individual weights of the four largest preovulatory follicles and number of large preovulatory follicles. The increased number of large follicles in the ovary was not associated with any change in egg production. It is apparent that the morphological disruptions associated with overfeeding broiler breeder hens can be identified within 7 d of full feeding, while any effects on egg production are not seen within the first 14 d of ad libitum feeding. Key words: Broiler breeder, feed intake, yolk deposition, ovarian morphology, egg production


1999 ◽  
Vol 276 (4) ◽  
pp. E728-E738 ◽  
Author(s):  
Thomas J. Wetter ◽  
Annie C. Gazdag ◽  
David J. Dean ◽  
Gregory D. Cartee

We evaluated the effects of 8 mo of calorie restriction [CR: 60% of ad libitum (AL) food intake] on glucose uptake by 14 tissues in unanesthetized, adult (12 mo) F344×BN rats. Glucose metabolism was assessed by the 2-[3H]deoxyglucose tracer technique at 1500 or 2100. Despite an ∼60% decline in insulinemia with CR, plasma 2-[3H]deoxyglucose clearance for CR was greater than for AL at both times. A small, CR-related decrease in glucose metabolic index ([Formula: see text]) occurred only at 1500 in the spleen and heart, and this decrease was reversed at 2100. In some tissues (cerebellum, lung, kidney, soleus, and diaphragm),[Formula: see text] was unaffected by diet, regardless of time. In the other tissues (brown fat, 3 white fat pads, epitrochlearis, plantaris, and gastrocnemius),[Formula: see text] was higher or tended to be higher for CR vs. AL at one or both times. These findings indicate that 8 mo of CR did not cause a continuous reduction in in vivo glucose uptake by any tissue studied, and, in several insulin-sensitive tissues, glucose uptake was at times greater for CR vs. AL rats.


1998 ◽  
Vol 1998 ◽  
pp. 131-131
Author(s):  
J. J. Hyslop ◽  
A. Bayley ◽  
A. L. Tomlinson ◽  
D. Cuddeford

De-hydrated forages are often fed to equids in the UK in place of more traditional grass hay, particularly where individual animals are known to have a sensitivity to dusty, mouldy hay which may play a part inducing respiratory problems such as chronic obstructive pulmonary disease (COPD). One such alternative forage is short-chop de-hydrated grass. However, there is very little information available on voluntary feed intake (VFI), apparent digestibility and nutrient intake parameters when de-hydrated grass is offered to equids compared with traditional grass hay. This study examines the VFI and apparent digestibility in vivo of a short-chop de-hydrated grass compared with a traditional grass hay and determines their ability to meet the predicted energy and protein needs of mature ponies.Six mature Welsh-cross pony geldings with a mean liveweight (LW) of 281 kg (s.e.d. 0.89) were individually housed and offered ad libitum access to either short-chop de-hydrated grass (DHG) or traditional grass hay (HAY) plus 60 g/h/d minerals. The DHG and HAY were made from the same 2nd cut perennial ryegrass sward cut on the same day.


2021 ◽  
Vol 14 (9) ◽  
pp. 3341-3352
Author(s):  
Loïc Arnold Mba Tene ◽  
Emile Miegoue ◽  
Marie Noëlle Bertine Noumbissi ◽  
Paulette Ntsafack ◽  
Camara Sawa ◽  
...  

The use of phytobiotics in feeding monogastric herbivores has several interests, including the stabilization of the caecal flora and especially the improvement of the growth of animals thanks to a better exploitation of feed resources. Thus a trial was conducted with an objective to evaluate the feed intake and post weaning growth performances of cavy according to the inclusion level of ginger meal. A total of 40 guinea pigs of 3 weeks of age were divided into 4 lots, and subjected to rations consisting of Trypsacum laxum served ad libitum, associated with the compound feed containing 0; 0.5; 0.75 and 1% ginger powder (T0, T1, T2 and T3). This study showed that the total intake of DM, MO and CB from forage was comparable between rations T0, T1 and T2 and significantly higher than those of ration T3. At weaning, average animal weights of all rations were comparable. However, at 8 weeks of age, the T0, T1 and T3 rations yielded comparable average weights, but significantly higher than those of the T2 animals, i.e., 272 g; 298.80 g; 285.25 g and 221.83 g, respectively. The T0, T1 and T3 diets recorded total gains that were comparable but significantly higher than those obtained with animals in Lot T2. Ginger powder can be included up to 0.75% in the diet as a feed additive for improved ingestion and 0.5% for post-weaning growth. L’usage des phytobiotiques dans l’alimentation des herbivores monogastriques présente plusieurs intérêts parmi lesquels la stabilisation de la flore caecale et surtout l’amélioration de la croissance des animaux grâce à une meilleure valorisation des ressources alimentaire. C’est ainsi que des essais ont été conduit avec pour objectif d’évaluer l’ingestion er la croissance post-sevrage des cobayes en fonction du niveau de la poudre de gingembre. Un total de 40 cobayes de 21 jours d’âge était reparti en 4 lots, et soumis à des rations constituées de Trypsacum laxum servi ad libitum, associé à l’aliment composé contenant 0 ; 0,5 ; 0,75 et 1% de poudre de gingembre (T0, T1, T2 et T3). Il ressort de cette étude que les ingestions totales de la MS, de la MO et de la CB du fourrage, ont été comparables entre les rations T0, T1 et T2 et significativement plus élevées que celle de la ration T3. Au sevrage, les poids moyens des animaux étaient comparables pour toutes les rations. Cependant à 8 semaines d’âge, les rations T0, T1 et T3 ont permis d’obtenir les poids moyens comparables, mais significativement plus élevés que ceux des animaux lot T2, soit respectivement 272 g ; 298,80 g ; 285,25 g et 221,83 g. Les rations T0, T1 et T3 ont permis d’enregistrer les gains totaux comparables, mais significativement élevés par rapport à ceux obtenus avec les animaux du lot T2. La poudre de gingembre peut être incluse jusqu’à 0,75% dans la ration comme additif alimentaire pour l'amélioration de l’ingestion et à 0,5% pour la croissance post-sevrage.


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