Studies on the carbohydrate metabolism of sheep. IX. Metabolic effects of glucose and glycerol in undernourished pregnant ewes and in ewes with pregnancy toxaemia

1960 ◽  
Vol 11 (1) ◽  
pp. 42 ◽  
Author(s):  
RL Reid
Keyword(s):  
Acetic Acid ◽  
Blood Glucose ◽  
Citric Acid ◽  
No Reduction ◽  
Clinical Signs ◽  
Metabolic Effects ◽  
Rapid Decline ◽  
Pronounced Increase ◽  
Pregnancy Toxaemia ◽  
Reduction Of Ketones

The rate of utilization of injected glucose by fasted pregnant ewes or ewes with pregnancy toxaemia is much more rapid than by fasted non-pregnant ewes. An apparent relation between the rate of utilization and the number of fetuses was observed; much of the injected glucose may be removed by the foetus(es). The pronounced rise in blood glucose recorded after lambing and when foetuses apparently died in utero is also considered to reflect sudden cessation of high foetal demands for glucose. Intravenous administration of glucose consistently reduced blood ketones in ewes with a moderate hyperketonaemia and showing no clinical signs of pregnancy toxaemia. Ketones declined in ewes fasted 1–3 days as soon as blood glucose began to increase at lambing. In ewes with pregnancy toxaemia there was usually no reduction of ketones in response to injected glucose; blood acetic acid levels, if previously high, did not decline; blood citric acid failed to increase. Glycerol given per os to ewes with pregnancy toxaemia always caused a rapid decline in blood ketones, and in acetic acid if the latter was previously high; a, pronounced increase in blood citric acid always occurred. These changes were recorded although no clinical improvement was observed. Glucose administered parenterally over 48 hr appeared to be less efficiently utilized by ewes with pregnancy toxaemia than by fasted pregnant ewes showing no clinical signs. Blood ketones declined to normal levels within 48 hr; in probable contrast to fasted ewes, this is considered to have occurred in the ewes with pregnancy toxaemia only because hyperglycaemia was continuously maintained. These results are considered to support the hypothesis that gluoose metabolism is depressed in ewes with pregnancy toxaemia and that the metabolic abnormalities are consistent with those characteristic of a diabetic-like syndrome.

Studies on the carbohydrate metabolism of sheep. X. Further studies on hypoglycaemia and hyperketonaemia in undernourished pregnant ewes and in ewes with pregnancy toxaemia

1960 ◽  
Vol 11 (3) ◽  
pp. 346 ◽  
Author(s):  
RL Reid
Keyword(s):  
Acetic Acid ◽  
Blood Glucose ◽  
Clinical Signs ◽  
Late Pregnancy ◽  
Clinical Syndrome ◽  
Glucose Levels ◽  
Under Nutrition ◽  
Blood Glucose Levels ◽  
Previous Level ◽  
Pregnancy Toxaemia

Data on blood glucose, ketone, and acetic acid values have been obtained over a period of several years from field cases of pregnancy toxaemia and from cases induced experimentally and their controls. When feed intake is controlled, differences between blood glucose and ketone levels in ewes moderately undernourished in late pregnancy are largely dependent on the number of foetuses. The consistency of these differences often allows accurate diagnosis of multiple and single pregnancies. Differences in blood glucose between undernourished monotocous and polytocous ewes disappear when undernutrition becomes severe or in the early stages of fasting after a period of moderate undernutrition. Differences in blood ketones tend to be maintained even after several days of fasting. The level of blood ketones during fasting depends on the previous level of nutrition of the ewe; blood glucose is unaffected by previous level of nutrition. The frequent presence of persistent normoglycaemia in ewes with pregnancy toxaemia is discussed in the light of data presented; it is concluded that the onset of pregnancy toxaemia often occurs in the presence of normal blood glucose levels. Blood volatile fatty acid (V.F.A.) levels are often high in those cases of pregnancy toxaemia which occur largely as a result of severe under nutrition in late pregnancy, in spite of an almost empty rumen. Only acetic acid was detected in six blood samples examined; this is considered to be of metabolic origin, but there is no consistent relationship with blood ketone level. The usual clinical syndrome of pregnancy toxaemia can be classified as acute or subacute. In the latter, cerebral depression reaches a certain stage of severity which is then maintained, survival is often prolonged, and ewes do not become comatose before death. Cases of pregnancy toxaemia induced by under nutrition alone usually show the acute syndrome. Blood ketones are higher in such cases than in fasted ewes showing no clinical signs; the critical blood ketone level appears to be about 30 mg per 100 ml. Cases induced in previously well-nourished ewes by fasting in association with a severe environmental stress are usually subacute; blood ketones are no higher than in ewes not showing clinical signs and are often considerably below 30 mg per 100 ml. The significance of these observations is discussed.

Studies on the carbohydrate metabolism of sheep. XI. The role of the adrenals in ovine pregnancy toxaemia

1960 ◽  
Vol 11 (3) ◽  
pp. 364 ◽  
Author(s):  
RL Reid
Keyword(s):  
Plasma Cortisol ◽  
Clinical Signs ◽  
Late Pregnancy ◽  
Metabolic Effects ◽  
Adrenal Steroid ◽  
Under Nutrition ◽  
Cortisol Levels ◽  
Pregnant Ewe ◽  
Pregnancy Toxaemia

Plasma cortisol levels in fed and fasted non-pregnant and in undernourished pregnant ewes were consistently less than 1.5 µg per 100 ml. Most values were considerably above this level in 20 field cases of pregnancy toxaemia, 31 of 52 values being greater than 3 µg per 100 ml. These levels must be regarded as abnormally high in sheep. Pregnancy toxaemia was induced in two experiments by fasting after a period of severe under nutrition and in two by fasting previously well-nourished ewes in the presence of severe psychological stresses. The onset of clinical signs was associated with marked increases above normal in plasma cortisol. In three experiments involving a total of 23 previously well-nourished ewes, 11 of which carried twins or triplets, only one mild case of pregnancy toxaemia was induced by complete fasting in late pregnancy for up to 6 days, in the absence of any additional environmental stress. Pregnancy toxaemia was readily induced in 24 of 38 ewes in three experiments when severe psychological stresses accompanied fasting in late pregnancy. Adrenal hypertrophy, indicating sustained adrenal hyperactivity, was most pronounced in field cases of pregnancy toxaemia induced primarily by sustained under nutrition. Fresh adrenal weights (total of two adrenals) averaged 6.7 g compared to 3.8 g in normal non-pregnant ewes. Mean plasma cortisol levels in ewes with pregnancy toxaemia were significantly correlated with fresh adrenal weight. The suggestions that abnormalities of carbohydrate and fat metabolism in ewes with pregnancy toxaemia are those of adrenal steroid diabetes, and that cerebral depression may be largely a consequence of a cortisol-induced inhibition of glucose utilization, are discussed in the light of the probable metabolic effects of cortisol in the undernourished pregnant ewe.

Studies on the carbohydrate metabolism of sheep. XIII. The interpretation of changes in the levels of metabolic intermediates after intravenous injection of propionate, succinate and malate

1961 ◽  
Vol 12 (5) ◽  
pp. 913 ◽  
Author(s):  
RL Reid ◽  
SC Mills
Keyword(s):  
Blood Glucose ◽  
Citric Acid ◽  
Intravenous Injection ◽  
Pyruvic Acid ◽  
Normal Glucose Tolerance ◽  
Blood Levels ◽  
Glucose Levels ◽  
Tolerance Curve ◽  
Pregnancy Toxaemia

Blood levels of pyruvic, citric, and �-oxoglutaric acids in sheep are similar to those in man. Citric acid declines markedly on fasting; levels in ewes with pregnancy toxaemia are not significantly different from those in fasted, pregnant ewes. The presence of low citric acid levels in ewes with pregnancy toxaemia in which blood glucose levels are normal or above may further support the suggestion that there is an interference with glucose utilization in pregnancy toxaemia. Intravenous injection of propionate, succinate, and malate into fasted, pregnant ewes always lowered blood ketones, but it is not known to what extent this response is merely a consequence of increased blood glucose following injection. Injected propionate disappeared more rapidly than injected acetate. Propionate injection into fed, non-pregnant ewes is followed by an immediate increase in blood glucose to high levels; the disappearance of excess glucose appears to follow the pattern of a normal glucose tolerance curve. Blood pyruvic acid increases markedly with blood glucose. Succinate and malate injections are followed by small increases in blood glucose and pyruvic acid. The difficulty of interpreting changes in blood glucose in inadequately trained experimental animals is emphasized. Consistent, significant increases in blood oxalaoetic acid did not occur in response to either propionate, succinate, or malate injection. Blood citric and a-oxoglutaric acids increased markedly after succinate and malate, but not after propionate injection. The data are discussed in relation to metabolic pathways in sheep tissues; it is concluded that this type of in vivo experiment is of limited value.

THE EFFECT OF THE PROGESTOGEN ETHYNODIOL DIACETATE ON GLUCOSE, INSULIN, AND GROWTH HORMONE AFTER SIX MONTHS TREATMENT

1972 ◽  
Vol 70 (2) ◽  
pp. 373-384 ◽  
Author(s):  
W. N. Spellacy ◽  
W. C. Buhi ◽  
S. A. Birk
Keyword(s):  
Growth Hormone ◽  
Blood Glucose ◽  
Plasma Insulin ◽  
Tolerance Test ◽  
Metabolic Effects ◽  
Oral Glucose ◽  
Hormone Levels ◽  
Glucose Levels ◽  
Ethynodiol Diacetate ◽  
Tolerance Curve

ABSTRACT Seventy-one women were treated with a daily dose of 0.25 mg of the progestogen ethynodiol diacetate. They were all tested with a three-hour oral glucose tolerance test before beginning the steroid and then again during the sixth month of use. Measurements were made of blood glucose and plasma insulin and growth hormone levels. There was a significant elevation of the blood glucose levels after steroid treatment as well as a deterioration in the tolerance curve in 12.9% of the women. The plasma insulin values were also elevated after drug treatment whereas the fasting ambulatory growth hormone levels did not significantly change. There was a significant association between the changes in glucose and insulin levels and the subject's age, control weight, or weight gain during treatment. The importance of considering the metabolic effects of the progestogen component of oral contraceptives is stressed.

Effect of pH, Acidulant, Time, and Temperature on the Growth and Survival of Listeria monocytogenes

1989 ◽  
Vol 52 (8) ◽  
pp. 571-573 ◽  
Author(s):  
KENT M. SORRELLS ◽  
DAVIN C. ENIGL ◽  
JOHN R. HATFIELD
Keyword(s):  
Antimicrobial Activity ◽  
Acetic Acid ◽  
Lactic Acid ◽  
Listeria Monocytogenes ◽  
Citric Acid ◽  
Hydrochloric Acid ◽  
Malic Acid ◽  
Incubation Temperature ◽  
Growth And Survival ◽  
Ph Values

The effect of different acids, pH, incubation time, and incubation temperature on the growth and survival of four strains of Listeria monocytogenes in tryptic soy broth was compared. Hydrochloric acid (HCl), acetic acid (AA), lactic acid (LA), malic acid (MA), and citric acid (CA) were used to acidify tryptic soy broth to pH values 4.4, 4.6, 4.8, 5.0, and 5.2 pH. Incubation times were 1, 3, 7, 14, and 28 d at 10, 25, and 35°C. The inhibition of L. monocytogenes in the presence of high acidity appears to be a function of acid and incubation temperature. Based on equal pH values, the antimicrobial activity is AA > LA > CA ≥ MA > HCl at all incubation times and temperatures. When based on equal molar concentration, the activity appeared to be CA ≥ MA > LA ≥ AA > HCl at 35 and 25°C, and MA > CA > AA ≥ LA > HCl at 10°C. Greatest antimicrobial activity occurred at 35°C. Greatest survival occurred at 10°C and greatest growth occurred at 25°C. Final pH of the medium was as low as 3.8 in HCl at 28 d. All strains grew well at pH values lower than the minimum previously reported (5.5–5.6).

scholarly journals Microbiological and Physicochemical Characterization of Small-Scale Cocoa Fermentations and Screening of Yeast and Bacterial Strains To Develop a Defined Starter Culture

2012 ◽  
Vol 78 (15) ◽  
pp. 5395-5405 ◽  
Author(s):  
Gilberto Vinícius de Melo Pereira ◽  
Maria Gabriela da Cruz Pedrozo Miguel ◽  
Cíntia Lacerda Ramos ◽  
Rosane Freitas Schwan
Keyword(s):  
Acetic Acid ◽  
Lactic Acid ◽  
Citric Acid ◽  
Dominant Species ◽  
Starter Culture ◽  
Physicochemical Characterization ◽  
Cocoa Bean ◽  
Small Scale ◽  
Content Type ◽  
Cocoa Bean Fermentation

ABSTRACTSpontaneous cocoa bean fermentations performed under bench- and pilot-scale conditions were studied using an integrated microbiological approach with culture-dependent and culture-independent techniques, as well as analyses of target metabolites from both cocoa pulp and cotyledons. Both fermentation ecosystems reached equilibrium through a two-phase process, starting with the simultaneous growth of the yeasts (withSaccharomyces cerevisiaeas the dominant species) and lactic acid bacteria (LAB) (Lactobacillus fermentumandLactobacillus plantarumwere the dominant species), which were gradually replaced by the acetic acid bacteria (AAB) (Acetobacter tropicaliswas the dominant species). In both processes, a sequence of substrate consumption (sucrose, glucose, fructose, and citric acid) and metabolite production kinetics (ethanol, lactic acid, and acetic acid) similar to that of previous, larger-scale fermentation experiments was observed. The technological potential of yeast, LAB, and AAB isolates was evaluated using a polyphasic study that included the measurement of stress-tolerant growth and fermentation kinetic parameters in cocoa pulp media. Overall, strainsL. fermentumUFLA CHBE8.12 (citric acid fermenting, lactic acid producing, and tolerant to heat, acid, lactic acid, and ethanol),S. cerevisiaeUFLA CHYC7.04 (ethanol producing and tolerant to acid, heat, and ethanol), andAcetobacter tropicalisUFLA CHBE16.01 (ethanol and lactic acid oxidizing, acetic acid producing, and tolerant to acid, heat, acetic acid, and ethanol) were selected to form a cocktail starter culture that should lead to better-controlled and more-reliable cocoa bean fermentation processes.

Efficacy Comparison of Some New Natural-Product Herbicides for Weed Control at Two Growth Stages

2009 ◽  
Vol 23 (3) ◽  
pp. 431-437 ◽  
Author(s):  
Hussein F. H. Abouziena ◽  
Ahmad A. M. Omar ◽  
Shiv D. Sharma ◽  
Megh Singh
Keyword(s):  
Acetic Acid ◽  
Citric Acid ◽  
Natural Product ◽  
Weed Control ◽  
Growth Stages ◽  
Clove Oil ◽  
Yellow Nutsedge ◽  
Natural Herbicides ◽  
Redroot Pigweed ◽  
Wild Mustard

There is an urgent need to accelerate the development and implementation of effective organic-compliant herbicides that are environmentally safe and that help the producer meet increasing consumer demand for organic products. Therefore, greenhouse experiments were conducted to evaluate the effectiveness of acetic acid (5%), acetic acid (30%), citric acid (10%), citric acid (5%) + garlic (0.2%), citric acid (10%) + garlic (0.2%), clove oil (45.6%), and corn gluten meal (CGM) compounds as natural-product herbicides for weed control. The herbicides were applied to the broadleaf weeds stranglervine, wild mustard, black nightshade, sicklepod, velvetleaf, and redroot pigweed and to narrowleaf weeds crowfootgrass, Johnsongrass, annual ryegrass, goosegrass, green foxtail, and yellow nutsedge. The herbicides were applied POST at two weed growth stages, namely, two to four and four to six true-leaf stages. CGM was applied PPI in two soil types. Citric acid (5%) + garlic (0.2%) had the greatest control (98%) of younger broadleaf weeds, followed by acetic acid (30%) > CGM > citric acid (10%) > acetic acid (5%) > citric acid (10%) + garlic (0.2%), and clove oil. Wild mustard was most sensitive to these herbicides, whereas redroot pigweed was the least sensitive. Herbicides did not control narrowleaf weeds except for acetic acid (30%) when applied early POST (EPOST) and CGM. Acetic acid (30%) was phytotoxic to all broadleaf weeds and most narrowleaf weeds when applied EPOST. Delayed application until the four- to six-leaf stage significantly reduced efficacy; acetic acid was less sensitive to growth stage than other herbicides. These results will help to determine effective natural herbicides for controlling weeds in organic farming.

scholarly journals Effect of organic acids fed through drinking water on carcass and internal organs of broiler chickens

2021 ◽  
Vol 41 (1) ◽  
pp. 60-67
Author(s):  
E. K. Ndelekwute ◽  
H. O. Uzegbu ◽  
K. U. Amaefule ◽  
C. O. Okereke ◽  
B. I. Umoh
Keyword(s):  
Drinking Water ◽  
Acetic Acid ◽  
Citric Acid ◽  
Gall Bladder ◽  
Organic Acids ◽  
Formic Acid ◽  
Butyric Acid ◽  
Broiler Chickens ◽  
Internal Organs ◽  
Carcass Yield

A Six week study was carried out to investigate effect of different organic acids (OAs) fed through drinking water on carcass yield and internal organs weight of broiler chickens. The OAs were acetic acid (AA) butyric acid (BA), citric acid (CA) and formic acid (FA). One hundred and fifty (150) day old AborAcre-plus chicks were used. There were five treatments. Treatment 1 which served as control (CON) consumed water with no organic acid, while treatments 2,3, 4 and5 respectively were offered drinking water treated with 0.25% acetic acid (AA), butyric acid (BA), citric acid (CA) and formic acid (FA). Each treatment was replicated three times each having 10 birds arranged in completely randomized design (CRD). Feed and water were offered ad libitum. Results showed that dressed carcass weight and breast weight were improved by all the organic acids. While only AA positively influenced the thigh weight, all the OAs drinking water fed resulted to smaller drumstick compared to the CON. Feeding of AA, BA and FA through drinking water increased (PSO.05) deposition of abdominal fat. Weight of pancreas, small intestine, caecum and large intestine was significantly (P<0.05) higher in CON. The gall bladder was significantly (P<0.05) bigger in all the OA groups. Conclusively, OAs could be fed through the drinking water for improved percentage carcass yield, breast meat and larger gall bladder and invariably bile volume

scholarly journals Effects of Pre-Cooking with Acetic Acid and Citric Acid on Residual Arsenic Content in Rice

2019 ◽  
Vol 29 (1) ◽  
pp. 553-559 ◽  
Author(s):  
Roya Behrouzi ◽  
Mohammad Hosein Marhamatizadeh ◽  
Shahram Shoeibi ◽  
Vadood Razavilar ◽  
Hossein Rastegar
Keyword(s):  
Acetic Acid ◽  
Citric Acid ◽  
Arsenic Content

Lead toxicosis in cats—a review

2003 ◽  
Vol 5 (5) ◽  
pp. 249-255 ◽  
Author(s):  
TE Knight ◽  
MSA Kumar
Keyword(s):  
Diagnostic Tests ◽  
Aminolevulinic Acid ◽  
Clinical Signs ◽  
Body Burden ◽  
Blood Lead ◽  
Good Prognosis ◽  
Metabolic Effects ◽  
Neuronal Necrosis ◽  
The Individual ◽  
High Index Of Suspicion

Although the incidence of lead toxicosis in small animals continues to decrease, it remains a significant malady. We have reviewed the literature of the past 45 years, which revealed 70 cases involving cats. Sources, signs, diagnosis, pathology and treatment of feline lead toxicosis are reviewed. In 84% of these cases the source of lead was old paint usually from home renovation. The most common signs in cats are anorexia, vomiting, and seizures. The younger individuals seem more likely to show CNS signs. Since signs are often vague, lead toxicosis may be significantly under diagnosed in cats. The gold standard of diagnostic tests is blood lead concentration, although it does not necessarily correlate with total body burden of lead or with metabolic effects including clinical signs. Diagnostic tests including erythropoietic protoporphyrin (EPP), urine aminolevulinic acid, and others are discussed. Gross findings on necropsy are few and include a yellow-brown discoloration of the liver often with a nutmeg-like appearance. Histological examination may reveal pathognomonic inclusion bodies in liver and renal tissues. Characteristic histological changes in the CNS include neuronal necrosis and demyelination. Treatment of lead toxicosis in cats, as in any species, involves removing the exposure, decontaminating the individual and the environment, supportive care and chelation therapy. The most recently available chelator is succimer (meso 2,3-dimercaptosuccinic acid). Succimer given orally is well tolerated and has a wide margin of safety. A high index of suspicion of lead toxicosis is warranted in cats since they often present with vague and non-specific signs. With any consistent history owners need to be asked about home renovation. Early diagnosis and treatment affords a good prognosis.

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